Gemcitabine-induced pseudocellulitis in a patient with non–small cell lung carcinoma

Gemcitabine-associated acute lipodermatosclerosislike eruption: An underrecognized phenomenon

“…1, 2, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15 Radiation recall events were excluded, as we believe they represent a separate category of cutaneous reactions and can be distinguished based on clinical history and physical findings.…”

“…We reviewed the literature for gemcitabine-related “pseudocellulitis,” “erysipeloid,” “lipodermatosclerosis,” and “scleroderma,” and created a table that includes the clinical features, demographics, risk factors, and treatment response of what we believe to be all previously described cases ( Table I ). 1 , 2 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 Radiation recall events were excluded, as we believe they represent a separate category of cutaneous reactions and can be distinguished based on clinical history and physical findings.…”

“…Ten patients (50%) were treated with antibiotics for presumed infectious cellulitis, and approximately half of these cases were treated with intravenous antibiotics. 1 , 2 , 4 , 6 , 7 , 9 , 10 , 11 , 12 Most (13 patients) continued gemcitabine despite the cutaneous adverse event, whereas treatment was discontinued in 6 patients with resolution of symptoms. When reported, improvement in skin lesions began within 24 to 48 hours in 4 patients, and significant improvement was noted within 1 week in 10 patients and within 2 weeks in 18 patients.…”

Unilateral Pemetrexed-induced Pseudocellulitis Mimicking Bacterial Cellulitis

“…Interestingly, pseudocellulitis has also been reported in patients treated with gemcitabine, another chemotherapeutic agent that interferes with DNA synthesis. 10,11 Recognizing the potential for pemetrexedinduced pseudocellulitis or other drug hypersensitivity reactions to present unilaterally could limit unnecessary use of broad-spectrum antibiotics, and in some cases, including this one, may require adjusting a patient's cancer treatment regimen.…”

Pemetrexed-induced lower limb pseudocellulitis

“…described a 50‐year‐old man who developed recurrent localized erysipeloid‐like lesions on his right leg after each course of intravenous gemcitabine infusion. More recently, Asemota et al . described a 77‐year old man who developed recurrent gemcitabine‐induced pseudocellulitis 2 days after receiving his third cycle of gemcitabine–carboplatin combination therapy.…”