Gemcitabine induced pneumonitis: a case report and review of literature

Thalambedu, Nishanth; El-Habr, A.

doi:10.1080/20009666.2020.1811071

Cited by 1 publication

(1 citation statement)

References 7 publications

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“… 14 Gemcitabine, tegafur/gimeracil/oteracil combination, and fluorouracil contain a type of nucleoside or degradation product of nucleoside, similar to the ones found in TAS-102. 15 The mechanism of gemcitabine-induced lung toxicity has been reported as cytokine-mediated inflammation of the alveolar capillary wall and development of increased membrane permeability, which causes DAD. 16 The type of nucleoside in TAS-102 is a similar to that in gemcitabine; thus, the mechanism of the development of drug-induced interstitial pneumonia in TAS-102 may be similar to that in gemcitabine.…”

Section: Discussionmentioning

confidence: 99%

Trifluridine and Tipiracil Hydrochloride Combination-Induced Interstitial Pneumonia: A Case Report

Nakazawa,

Kato,

Terayama

et al. 2024

IMCRJ

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We report a case of a 62-year-old male who was diagnosed with advanced rectal cancer. The attending gastro-enterologist initiated chemotherapy using capecitabine plus oxaliplatin and bevacizumab; however, this treatment regimen was discontinued, as the patient developed a skin rash. Once the skin rash improved, chemotherapy was re-initiated using a combination of trifluridine and tipiracil hydrochloride (TAS-102). The patient developed high fever and dyspnea 2 months after initiation of TAS-102. Chest high-resolution computed tomography showed bilateral diffuse ground glass opacities in all lung lobes with traction bronchiectasis. At this time, the gastro-enterologist consulted our department. The patient was put on non-invasive positive pressure ventilation due to worsening respiratory symptoms. The patient was suspected to develop TAS-102-induced interstitial pneumonia based on positive TAS-102 drug-induced lymphocyte stimulation test. The patient’s respiratory symptoms and radiological findings improved after corticosteroid treatment. The corticosteroid dose was gradually decreased by 5 mg. Thereafter, chemotherapy was re-initiated using different anti-cancer agents.

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Section: Discussionmentioning

confidence: 99%