Gemcitabine-induced atrial fibrillation: A hitherto unreported manifestation of drug toxicity

Santini, Daniele; Tonini, Giuseppe; Abbate, Antonio; Cosimo, Serena Di; Gravante, G.; Vincenzi, Bruno; Campisi, C; Patti, Giuseppe; Sciascio, Germano Di

doi:10.1023/a:1008380208045

Cited by 43 publications

(31 citation statements)

References 9 publications

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“…CP is one of the most related chemotherapeutic agents with atrial fibrillation and it can improve the production of thromboxanes by platelets, activate platelet aggregation and induce thrombotic arachidonic acid pathway 23,24 . Dolci et al 20 have classified the chemotherapy induced cardiotoxicity in two patterns: (1) Acute or subacute cardiotoxicity and (2) CP-induced cardiotoxicity is related to excessive oxidative stress and apoptosis 25 .…”

Section: Discussionmentioning

confidence: 99%

Effects of thymoquinone against cisplatin-induced cardiac injury in rats

et al. 2016

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PURPOSE: To investigate the possible protective effect of thymoquinone (TQ) in cisplatin (CP) induced myocardial injury. METHODS:A total of 28 adult male Wistar-Albino rats were randomly and equally divided into four groups as follows: Group 1 (control), Group 2 (CP at 15 mg/kg dose), Group 3 (TQ 40 mg/kg/day for two days prior to CP injection and on third day, CP at 15 mg/kg dose was intraperitoneally administered and TQ treatment continued until fifth day) and Group 4 (TQ at 40mg/kg/day dose for five days). RESULTS:There was a significant increment in CP group in terms of congestion, edema and pycnotic nuclei in myocardial fibers, comparing with other groups. TQ group exhibited significant increase in expression of antiapoptotic protein Bcl-2, comparing with CP group (p<0.05). In only CP administered group, expression of antiapoptotic protein Bcl-2 was lowest comparing with other groups. CONCLUSION:Established data indicate that cisplatin is cardiotoxic and thymoquinone may be useful in treating CP-induced cardiac injury.

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Section: Discussionmentioning

confidence: 99%

Effects of thymoquinone against cisplatin-induced cardiac injury in rats

et al. 2016

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“…Most of these report supraventricular tachycardias including atrial fibrillation 8, 9. Atrial fibrillation is typically seen 18–24 h of infusion.…”

Section: Discussionmentioning

confidence: 99%

Gemcitabine induced cardiomyopathy: a case of multiple hit cardiotoxicity

2016

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Gemcitabine is a commonly used antineoplastic agent used to treat a variety of cancers with rarely reported cardiac side effects. We describe a case of a 67‐year‐old woman with follicular lymphoma who experienced a rarely reported side effect of gemcitabine: cardiomyopathy. This case highlights a multiple hit mechanism of myocyte damage that may occur following the use of multiple cardio‐toxic agents despite their administration in doses not associated with cardiotoxicity.

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“…Cases of atrial arrhythmia, supraventricular tachycardia, bradycardia, ST-T wave changes, left bundle branch block, acute ischemic events, myocardial infarction, myopathy have been reported during treatment with cisplatin [4,5]. Furthermore, cisplatin is one of the most frequently cytotoxic drugs associated with atrial fibrillation (AF) [6]. According to some authors, direct myocardial toxicity may have role in the development of cisplatin-related AF [7].…”

Section: Discussionmentioning

confidence: 99%

Recurrent Complete Atrioventricular Block During Cisplatin Infusion: A Case Report

Özcan¹,

Cirit²,

Kıykım³

2011

J Clinic Experiment Cardiol

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Cisplatin is one of the most effective chemotherapeutic agents used in the treatment of malignancies. The clinical use of cisplatin is limited by its severe adverse effects. Acute or long term cardiotoxicity is the most important doselimiting toxicity of cisplatin Cases of angina, myocardial infarction, and atrial arrhythmia have been reported during continuous infusion of cisplatin, but atrioventricular block (AV) has not been reported. Herein, we report a case with recurrent AV block that developed during cisplatin infusion, for the first time.

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Gemcitabine-induced atrial fibrillation: A hitherto unreported manifestation of drug toxicity

Cited by 43 publications

References 9 publications

Effects of thymoquinone against cisplatin-induced cardiac injury in rats

Effects of thymoquinone against cisplatin-induced cardiac injury in rats

Gemcitabine induced cardiomyopathy: a case of multiple hit cardiotoxicity

Recurrent Complete Atrioventricular Block During Cisplatin Infusion: A Case Report

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