GelMA/TCP nanocomposite scaffold for vital pulp therapy

Han, Yuanyuan; Dal-Fabbro, Renan; Mahmoud, Abdel H.; Rahimnejad, Maedeh; Xu, Jinping; Castilho, Miguel; Dissanayaka, Waruna L.; Bottino, Marco C.

doi:10.1016/j.actbio.2023.11.005

Cited by 9 publications

(3 citation statements)

References 60 publications

(45 reference statements)

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“…However, this nanocomposite scaffold exhibited a relatively limited functionality, lacking anti-inflammatory effects, whereas the resolution of inflammation is crucial for vital pulp preservation. 43 , 59 …”

Section: Resultsmentioning

confidence: 99%

“…This GelMA/TCP composite demonstrated the capacity to induce the differentiation of odontoblast-like cells capable of secreting dentin matrix in vitro. 17 However, there still remains a significant gap in the comprehensive evaluation of the efficacy that these nanocomposite hydrogels have in VPT. It is crucial to advance the development of novel strategies that holistically address inflammation control and dentin mineralization for efficient VPT in clinical settings.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Novel L-(CaP-ZnP)/SA Nanocomposite Hydrogel with Dual Anti-Inflammatory and Mineralization Effects for Efficient Vital Pulp Therapy

Zhang,

Zhou,

Zhai

et al. 2024

IJN

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Novel L-(CaP-ZnP)/SA Nanocomposite Hydrogel with Dual Anti-Inflammatory and Mineralization Effects for Efficient Vital Pulp Therapy

Zhang,

Zhou,

Zhai

et al. 2024

IJN

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“…Such foams have been shown to be good carriers for the antibiotic tetracycline [801]. In addition, electrospun gelatin methacryloyl fibrous scaffold incorporating β-TCP was developed for vital pulp therapy [804].…”

Section: Biocomposites With Other Bio-organic Compoundsmentioning

confidence: 99%

Calcium Orthophosphate (CaPO4) Containing Composites for Biomedical Applications: Formulations, Properties, and Applications

Dorozhkin

2024

J. Compos. Sci.

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The goal of this review is to present a wide range of hybrid formulations and composites containing calcium orthophosphates (abbreviated as CaPO4) that are suitable for use in biomedical applications and currently on the market. The bioactive, biocompatible, and osteoconductive properties of various CaPO4-based formulations make them valuable in the rapidly developing field of biomedical research, both in vitro and in vivo. Due to the brittleness of CaPO4, it is essential to combine the desired osteologic properties of ceramic CaPO4 with those of other compounds to create novel, multifunctional bone graft biomaterials. Consequently, this analysis offers a thorough overview of the hybrid formulations and CaPO4-based composites that are currently known. To do this, a comprehensive search of the literature on the subject was carried out in all significant databases to extract pertinent papers. There have been many formulations found with different material compositions, production methods, structural and bioactive features, and in vitro and in vivo properties. When these formulations contain additional biofunctional ingredients, such as drugs, proteins, enzymes, or antibacterial agents, they offer improved biomedical applications. Moreover, a lot of these formulations allow cell loading and promote the development of smart formulations based on CaPO4. This evaluation also discusses basic problems and scientific difficulties that call for more investigation and advancements. It also indicates perspectives for the future.

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Photo‐crosslinkable hydrogel incorporated with bone matrix particles for advancements in dentin tissue engineering

da Silva,

Bordini,

Bronze‐Uhle

et al. 2024

J Biomedical Materials Res

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The objective of this study was to create injectable photo‐crosslinkable biomaterials, using gelatin methacryloyl (GelMA) hydrogel, combined with a decellularized bone matrix (BMdc) and a deproteinized (BMdp) bovine bone matrix. These were intended to serve as bioactive scaffolds for dentin regeneration. The parameters for GelMA hydrogel fabrication were initially selected, followed by the incorporation of BMdc and BMdp at a 1% (w/v) ratio. Nano‐hydroxyapatite (nHA) was also included as a control. A physicochemical characterization was conducted, with FTIR analysis indicating that the mineral phase was complexed with GelMA, and BMdc was chemically bonded to the amide groups of gelatin. The porous structure was preserved post‐BMdc incorporation, with bone particles incorporated alongside the pores. Conversely, the mineral phase was situated inside the pore opening, affecting the degree of porosity. The mineral phase did not modify the degradability of GelMA, even under conditions of type I collagenase‐mediated enzymatic challenge, allowing hydrogel injection and increased mechanical strength. Subsequently, human dental pulp cells (HDPCs) were seeded onto the hydrogels. The cells remained viable and proliferative, irrespective of the GelMA composition. All mineral phases resulted in a significant increase in alkaline phosphatase activity and mineralized matrix deposition. However, GelMA‐BMdc exhibited higher cell expression values, significantly surpassing those of all other formulations. In conclusion, our results showed that GelMA‐BMdc produced a porous and stable hydrogel, capable of enhancing odontoblastic differentiation and mineral deposition when in contact with HDPCs, thereby showing potential for dentin regeneration.

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GelMA/TCP nanocomposite scaffold for vital pulp therapy

Cited by 9 publications

References 60 publications

Novel L-(CaP-ZnP)/SA Nanocomposite Hydrogel with Dual Anti-Inflammatory and Mineralization Effects for Efficient Vital Pulp Therapy

Novel L-(CaP-ZnP)/SA Nanocomposite Hydrogel with Dual Anti-Inflammatory and Mineralization Effects for Efficient Vital Pulp Therapy

Calcium Orthophosphate (CaPO4) Containing Composites for Biomedical Applications: Formulations, Properties, and Applications

Photo‐crosslinkable hydrogel incorporated with bone matrix particles for advancements in dentin tissue engineering

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