GelMA micropattern enhances cardiomyocyte organization, maturation, and contraction via contact guidance
Bin Zhang,
Yichen Luo,
Xue Zhou
et al.
Abstract:Cardiac tissue engineering has emerged as a promising approach for restoring the functionality of damaged cardiac tissues following myocardial infarction. To effectively replicate the native anisotropic structure of cardiac tissues in vitro, this study focused on the fabrication of micropatterned gelatin methacryloyl hydrogels with varying geometric parameters. These substrates were evaluated for their ability to guide induced pluripotent stem cell-derived cardiomyocytes (CMs). The findings demonstrate that th… Show more
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