GelMA hydrogel dual photo-crosslinking to dynamically modulate ECM stiffness
Josephina J. H. M. Smits,
Atze van der Pol,
Marie José Goumans
et al.
Abstract:The dynamic nature of the extracellular matrix (ECM), particularly its stiffness, plays a pivotal role in cellular behavior, especially after myocardial infarction (MI), where cardiac fibroblasts (cFbs) are key in ECM remodeling. This study explores the effects of dynamic stiffness changes on cFb activation and ECM production, addressing a gap in understanding the dynamics of ECM stiffness and their impact on cellular behavior. Utilizing gelatin methacrylate (GelMA) hydrogels, we developed a model to dynamical… Show more
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