Gellan gum incorporating titanium dioxide nanoparticles biofilm as wound dressing: Physicochemical, mechanical, antibacterial properties and wound healing studies

Ismail, Noor Azizi; Amin, Khairul Anuar Mat; Majid, Fadzilah Adibah Abdul; Razali, Mohd Hasmizam

doi:10.1016/j.msec.2019.109770

Cited by 105 publications

(46 citation statements)

References 63 publications

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“…Then, the photo-generated electron will react with molecular oxygen as well as with water to produce superoxide radical anions (•O 2 −) and hydroxyl (•OH) radicals, respectively. Therefore, these reactive radicals will executed the bacteria by decomposed the Journal of Pure and Applied Microbiology organic compounds in bacterial cells [24][25][26][27][28] . The result obtained suggesting that, TiO 2 -NRs is a promising antibacterial agent as GG+TiO 2 -NRs films exhibited excellent antimicrobial property.…”

Section: Resultsmentioning

confidence: 99%

Fabrication and Characterization of Antibacterial Titanium Dioxide Nanorods Incorporating Gellan Gum Films

Razali¹,

Ismail²,

Amin³

2019

J Pure Appl Microbiol

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The aim of this work was to develop bionanocomposite films based biopolymer GG and TiO 2 -NRs for active food packaging. The TiO 2 -NRs were incorporated as antimicrobials agent into GG via solvent casting method. The films appearance was have 94 % of transparency. SEM micrographs indicate that the TiO 2 -NRs were successfully incorporated and attached to the surface of developed GG films. FTIR results revealed the interaction between TiO 2 -NRs and hydroxyl group of GG polymer. XRD results showed the crystalline peaks of TiO 2 -NRs and amorphous peaks of GG+TiO 2 -NRs films. The thermal stability of GG films were increasing by incorporation of TiO 2 -NRs materials. The GG+TiO 2 -NRs films showed good antibacterial activity against Gram-positive (Staphylococcus aureus (S. aureus) and Streptococcus (strep.)) and Gram-negative (Escherichia coli (E. coli) and Pseudomonas aeruginosa (P. aeruginosa)) and potentially used as antibacterial packaging films.

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Section: Resultsmentioning

confidence: 99%

Fabrication and Characterization of Antibacterial Titanium Dioxide Nanorods Incorporating Gellan Gum Films

Razali¹,

Ismail²,

Amin³

2019

J Pure Appl Microbiol

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“…Schematic representation of the functionalization of polysaccharide-based materials with TiO 2 (a) and their effects on the UV-blocking (b), mechanical (c), gas exchange (d), thermal (e), swelling (f), and adsorptive (g) properties (adapted from Hou et al [34], Goudarzi et al [35], de Moura et al [36], and Dai et al [37]) (figure created in Biorender.com). (a) and their main applications: sensor development (b), antimicrobial activity (c), food and non-food packaging (d), wastewater treatment (e), solar cells and energy storage systems (f), wound-healing (g), and controlled drug release (h) (adapted from de Moura et al [36], Dai et al [37], Ismail et al [38], and Al-Morakam [39]) (table created in Biorender.com).…”

Section: Polysaccharide-tio 2 Hybrid Materialsmentioning

confidence: 99%

Use of Titanium Dioxide (TiO2) Nanoparticles as Reinforcement Agent of Polysaccharide-Based Materials

et al. 2020

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In recent years, a strong interest has emerged in polysaccharide-hybrid composites and their potential applications, which have interesting functional and technological properties. This review summarizes and discusses the reported advantages and limitations of the functionalization of conventional and nonconventional polysaccharides by adding TiO2 nanoparticles as a reinforcement agent. Their effects on the mechanical, thermal, and UV-barrier properties as well as their water-resistance are discussed. In general, the polysaccharide–TiO2 hybrid materials showed improved physicochemical properties in a TiO2 content-dependent response. It showed antimicrobial activity against bacteria (gram-negative and gram-positive), yeasts, and molds with enhanced UV-protective effects for food and non-food packaging purposes. The reported applications of functionalized polysaccharide–TiO2 composites include photocatalysts (dye removal from aqueous media and water purification), biomedical (wound-healing material, drug delivery systems, biosensor, and tissue engineering), food preservation (fruits and meat), cosmetics (sunscreen and bleaching tooth treatment), textile (cotton fabric self-cleaning), and dye-sensitized solar cells. Furthermore, the polysaccharide–TiO2 showed high biocompatibility without adverse effects on different cell lines, indicating that their use in food, pharmaceutical, and biomedical applications is safe. However, it is necessary to evaluate the structural changes promoted by the storage conditions (time and temperature) on the physicochemical properties of polysaccharide–TiO2 hybrid composites to guarantee their stability during a determined time.

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“…Gellan nanocomposite film was prepared with impregnation of iodine-loaded poly(silicic acid) nanosuspension. In earlier research, nanoparticles-loaded gellan nanocomposite films are also reported for example, TiO 2 nanoparticles-loaded gellan gum biofilm as wound dressing 15 and sericin-chitosan doped maleate gellan gum nanocomposite for Mycobacterium tuberculosis cell damage. 37 A study reported the use of mucoadhesive gellan gum/glucosamine clioquinol film for oral cancer treatment in the form of patch, 38 stretching), 1606.30 (carboxyl group), and 1465.20 cm −1 (C C vibration bond).…”

Section: Preparation and Characterization Of Iodine-loaded Poly(silmentioning

confidence: 99%

“…Moisture penetration through films changes due to alteration in the amorphous and crystalline nature of films. 15,41 Folding endurance gives the estimation of mechanical strength. It was observed from the study that iodineloaded poly(silicic acid) gellan nanocomposite film have to be folded 1.8 times more than gellan film for breakage.…”

Section: Evaluation Of Gellan Film and Iodine-loaded Poly(silicic Amentioning

confidence: 99%

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Iodine‐loaded poly(silicic acid) gellan nanocomposite mucoadhesive film for antibacterial application

Pahwa

Ahuja

2020

J of Applied Polymer Sci

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Iodine‐loaded poly(silicic acid) gellan nanocomposite film was fabricated and evaluated for antibacterial properties. Poly(silicic acid) nanoparticles were synthesized by condensation of silicic acid under alkaline conditions in the presence of polyvinyl pyrrolidone, phosphate ions, and molecular iodine. The nanoparticles were incorporated into gellan dispersion to prepare gellan nanocomposite film using the solvent casting method. The nanocomposite films were characterized by Fourier transformed infrared spectroscopy, thermogravimetric analysis, and X‐ray diffraction studies. The results of characterization studies indicated improved thermal stability and an increase in the degree of crystallinity. The scanning electron micrographs and energy dispersive X‐ray spectrum confirmed the uniform dispersion of silica and iodine in the nanocomposite films. The analysis of physical and mechanical properties revealed the enhanced tensile strength, moisture resistance, and higher folding endurance of poly(silicic acid) gellan nanocomposite films as compared to gellan film. Further, the iodine‐loaded poly(silicic acid) gellan nanocomposite films showed good antibacterial activity against Staphylococcus aureus and Escherichia coli and effective mucoadhesive strength. The results indicate that iodine‐loaded poly(silicic acid) gellan nanocomposite mucoadhesive film can be used for potential antibacterial applications in pharmaceuticals.

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Gellan gum incorporating titanium dioxide nanoparticles biofilm as wound dressing: Physicochemical, mechanical, antibacterial properties and wound healing studies

Cited by 105 publications

References 63 publications

Fabrication and Characterization of Antibacterial Titanium Dioxide Nanorods Incorporating Gellan Gum Films

Fabrication and Characterization of Antibacterial Titanium Dioxide Nanorods Incorporating Gellan Gum Films

Use of Titanium Dioxide (TiO2) Nanoparticles as Reinforcement Agent of Polysaccharide-Based Materials

Iodine‐loaded poly(silicic acid) gellan nanocomposite mucoadhesive film for antibacterial application

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