Gellan Gum and Its Composites: Suitable Candidate for Efficient Nanodrug Delivery

Sweety, J. Pushpa; Selvasudha, Nandakumar; Dhanalekshmi, U. M.; Sridurgadevi, Nagarajan

doi:10.1002/9783527832095.ch2

Cited by 3 publications

(1 citation statement)

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“…These properties make it an interesting material for the setup of various DDSs, including particles, films, fibers, and hydrogels. The pH-dependent swelling and stability of GG are desirable properties for DDS formulation, as well as its anionic nature that enables its gelation when combined with monovalent or divalent cations [ 86 ].…”

Section: Gellan Gum (Gg)mentioning

confidence: 99%

Current Status of Polysaccharides-Based Drug Delivery Systems for Nervous Tissue Injuries Repair

et al. 2023

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Neurological disorders affecting both CNS and PNS still represent one of the most critical and challenging pathologies, therefore many researchers have been focusing on this field in recent decades. Spinal cord injury (SCI) and peripheral nerve injury (PNI) are severely disabling diseases leading to dramatic and, in most cases, irreversible sensory, motor, and autonomic impairments. The challenging pathophysiologic consequences involved in SCI and PNI are demanding the development of more effective therapeutic strategies since, as yet, a therapeutic strategy that can effectively lead to a complete recovery from such pathologies is not available. Drug delivery systems (DDSs) based on polysaccharides have been receiving more and more attention for a wide range of applications, due to their outstanding physical-chemical properties. This review aims at providing an overview of the most studied polysaccharides used for the development of DDSs intended for the repair and regeneration of a damaged nervous system, with particular attention to spinal cord and peripheral nerve injury treatments. In particular, DDSs based on chitosan and their association with alginate, dextran, agarose, cellulose, and gellan were thoroughly revised.

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Section: Gellan Gum (Gg)mentioning

confidence: 99%