“…This is to act as a scaffold for the migration of epithelium and consequent closure of the defect. The materials used in previous studies have included silastic sheeting [12], gelfoam patching [13,20], gelfilm patching [6,13,20,23], gelfoam plug [14], steri-strip TM (3 M) or paper patching [5,6,[15][16][17][18][19], fat plug [6,21] and trichloroacetic acid [22]. The majority of these studies (see Table 1) were retrospective reviews and only one [12] was a randomised non-blinded controlled trial in which the incidence of persistent perforation was observed following freshening of the edges of the perforation and freshening of the edges with application of silastic sheeting to the defect.…”