Gelatin/starch orally disintegrating films as a promising system for vitamin C delivery

Garcia, Vitor Augusto dos Santos; Borges, Josiane Gonçalves; Maciel, Vinícius Borges Vieira; Mazalli, Mônica Roberta; Lapa‐Guimarães, Judite; Vanin, Fernanda Maria; Carvalho, Rosemary Aparecida de

doi:10.1016/j.foodhyd.2017.12.027

Cited by 49 publications

(30 citation statements)

References 46 publications

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“…The production of starch-gelatin polymer films started in the late nineties aiming at allying the properties of materials made of proteins and polysaccharides in a single polymer [1,2]. After more than three decades, this blend is still the subject of research [3][4][5][6][7][8][9][10][11][12][13][14][15][16]. Films produced from gelatin (or collagen hydrolysate) obtained from leather wastes are of special interest [9,12,[17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

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Starch-Leather Waste Gelatin Films Cross-Linked with Glutaraldehyde

et al. 2020

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Gelatin extracted from chromium-tanned leather wastes (CTLW) has a lower molar mass because of the more aggressive extraction process needed to disrupt chromium-collagen bonds when compared to gelatin extracted from the bones, skin, and connective tissues of animals. As a consequence, CTLW gelatin is more hydrophilic, thus it is harder to apply in the production of polymers. To overcome this issue, in this study, films produced with starch, CTLW gelatin, commercial gelatin (as a comparative), and their blends were cross-linked with glutaraldehyde. The cross-linking reduced the crystallinity of the films, impairing the reorganization of gelatin chains into a triple helix structure, which balanced the effect of the higher molecular chain, while not altering the films' tensile strength. It increased the elongation at break and reduced the solubility and the swelling degree by up to 53% and 69%, respectively. These results stand as a great advance for the practical use of starch-CTLW gelatin films.

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Section: Introductionmentioning

confidence: 99%

“…The addition of essential oils and ethyl lauryl alginate, for example, may confer them antifungal properties [5,25]. This blend is also applied in biomedicine, especially in drug delivery systems [3,10,26] and might be used in agriculture as well [27][28][29][30].…”

Section: Introductionmentioning

confidence: 99%

Starch-Leather Waste Gelatin Films Cross-Linked with Glutaraldehyde

et al. 2020

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“…Nanoliposomes themselves are stabilized by the presence of antioxidants such as ACNs and biopolymer-based coatings (for example, layer-by-layer chitosan/pectin-coated liposomes) [ 144 , 145 ]. Although it has yet not been applied to ACNs, orally disintegrating films composed of gelatine/starch were used as potential carriers of vitamin C, which, similar to ACNs, is a kind of antioxidant compound that is likely to degrade under light [ 146 ]. This research is certain to promote further investigations into strategies to protect and enhance the bioavailability of other unstable substances, such as ACNs.…”

Section: Technology In Fabricating Acn-rich Bbs Into Delivery Systmentioning

confidence: 99%

Blueberry Supplementation in Neuronal Health and Protective Technologies for Efficient Delivery of Blueberry Anthocyanins

Tran

2021

Biomolecules

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Blueberries are consumed as healthy fruits that provide a variety of benefits to the nervous system. Scientists have found that blueberries can be used as a daily edible source for supplementation to prevent and minimize complexities of age-related diseases as well as to improve learning and memory in children. Anthocyanins are the most mentioned compounds among the components in blueberries, as they play a major role in providing the health benefits of this fruit. However, while they are highly active in impeding biological impairment in neuronal functions, they have poor bioavailability. This review focuses on neurological investigations of blueberries from in vitro cell studies to in vivo studies, including animal and human studies, with respect to their positive outcomes of neuroprotection and intervention in neurodegenerative conditions. Readers will also find information on the bioavailability of anthocyanins and the considerable factors affecting them so that they can make informed decisions regarding the daily consumption of blueberries. In this context, the ways in which blueberries or blueberry supplementation forms are consumed and which of these forms is best for maximizing the health benefits of blueberries should be considered important decision-making factors in the consumption of blueberries; all of these aspects are covered in this review. Finally, we discuss recent technologies that have been employed to improve the bioavailability of blueberry anthocyanins in the development of effective delivery vehicles supporting brain health.

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“…138 The ionic crosslinking and DC were evaluated as a novel mucoadhesive DDS by de Oliveira Cardoso et al In this experiment, blends of natural polysaccharides, gellan gum and retrograded starch hydrogels loaded with KET were proposed resulting in hydrogels with various rheological and mechanical properties and improvements in texture, as well as sustained drug release rate. 139 The blending of starch and gelatin and their predominant effect on controlled drug release-for methylthioninium, 140 ascorbic acid 141 and vancomycin hydrochloride 142 -have been reported.…”

Section: Applications Of Starch and Its Blend Derivatives In Cddssmentioning

confidence: 99%

<p>Burgeoning Polymer Nano Blends for Improved Controlled Drug Release: A Review</p>

Maghsoudi¹,

Shahraki²,

Rabiee³

et al. 2020

IJN

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With continual rapid developments in the biomedical field and understanding of the important mechanisms and pharmacokinetics of biological molecules, controlled drug delivery systems (CDDSs) have been at the forefront over conventional drug delivery systems. Over the past several years, scientists have placed boundless energy and time into exploiting a wide variety of excipients, particularly diverse polymers, both natural and synthetic. More recently, the development of nano polymer blends has achieved noteworthy attention due to their amazing properties, such as biocompatibility, biodegradability and more importantly, their pivotal role in controlled and sustained drug release in vitro and in vivo. These compounds come with a number of effective benefits for improving problems of targeted or controlled drug and gene delivery systems; thus, they have been extensively used in medical and pharmaceutical applications. Additionally, they are quite attractive for wound dressings, textiles, tissue engineering, and biomedical prostheses. In this sense, some important and workable natural polymers (namely, chitosan (CS), starch and cellulose) and some applicable synthetic ones (such as poly-lactic-co-glycolic acid (PLGA), poly(lactic acid) (PLA) and poly-glycolic acid (PGA)) have played an indispensable role over the last two decades for their therapeutic effects owing to their appealing and renewable biological properties. According to our data, this is the first review article highlighting CDDSs composed of diverse natural and synthetic nano biopolymers, blended for biological purposes, mostly over the past five years; other reviews have just briefly mentioned the use of such blended polymers. We, additionally, try to make comparisons between various nano blending systems in terms of improved sustained and controlled drug release behavior.

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Gelatin/starch orally disintegrating films as a promising system for vitamin C delivery

Cited by 49 publications

References 46 publications

Starch-Leather Waste Gelatin Films Cross-Linked with Glutaraldehyde

Starch-Leather Waste Gelatin Films Cross-Linked with Glutaraldehyde

Blueberry Supplementation in Neuronal Health and Protective Technologies for Efficient Delivery of Blueberry Anthocyanins

<p>Burgeoning Polymer Nano Blends for Improved Controlled Drug Release: A Review</p>

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