Gelatin-specific humoral and cellular immune responses in children with immediate- and nonimmediate-type reactions to live measles, mumps, rubella, and varicella vaccines☆☆☆★

Kumagai, Toshiko; Yamanaka, Tatsuru; Wataya, Yasuhiko; Umetsu, Aiko; Kawamura, N.; Ikeda, Kazuo; Furukawa, Hidetsugu; Kimura, Kensyu; Chiba, Shunzo; Sakai, Saburo; Sugawara, Naoto; Kurimoto, Fumihiko; Sakaguchi, Masahiro; Inouye, Sakae

doi:10.1016/s0091-6749(97)70204-5

Cited by 78 publications

(39 citation statements)

References 18 publications

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“…Therefore, it was assumed that sufficient stimulation for the generation of adequate antibody titers against both viruses may have been achieved through natural infection; in particular, immunity to varicella was strongly influenced by natural infection (23)(24)(25). The mumps vaccine was included in the MMR vaccine program for 5 years (1989-1993), likely affecting subjects who were immunized during that period.…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence of Measles- and Mumps-Specific Immunoglobulin G among Japanese Healthcare Students Increased during 2007–2012

et al. 2013

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SUMMARY:We evaluated the seroprevalence of vaccine-preventable infectious diseases among Japanese healthcare students to create immunization guidelines. Between 2007 and 2012, a total of 1746 Japanese medical, nursing, and paramedical students were serologically screened for measles, mumps, rubella, varicella, and hepatitis B virus (HBV) antibodies at the time of admission. In 2007, the seroprevalence of measles and mumps was 52.7z and 65.6z, respectively. The seroprevalence of measles dramatically increased to 96.6z in 2009 and was then sustained at À90z. The seroprevalence of mumps gradually increased to À80.0z between 2010 and 2012. The seroprevalence of rubella remained at À90z except in 2008 (85.6z), and the seroprevalence of varicella was sustained at À92z throughout 2007-2012. The seroprevalence of HBV antibody remained at º7z during 2007-2012. Although the seroprevalence of vaccine-preventable infectious diseases among Japanese healthcare students increased during the 2007-2012 study period, a substantial number of students were susceptible to vaccine-preventable infectious diseases. Therefore, we propose targeted immunization of Japanese healthcare students using serological screening prior to clinical training.

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Section: Discussionmentioning

confidence: 99%

Seroprevalence of Measles- and Mumps-Specific Immunoglobulin G among Japanese Healthcare Students Increased during 2007–2012

et al. 2013

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“…Cependant, les injections de vaccins peuvent induire des ré-actions allergiques du type immédiat, comme des réactions anaphylactiques et des urticaires et/ou angioedèmes aux vaccins contenant des anatoxines [12,41,53], de l'ovalbumine [6,24], de la gélatine [32,49,50,52], et des antigènes pneumococciques [42]. Les vaccins contenant du dextran (BCG ® ) peuvent induire des réactions anaphylactoïdes dépendant des IgG [25,48].…”

Section: -104unclassified

“…Certaines sont locales, comme les eczémas induits par l'hydroxyde d'aluminium [14,26], le mercurothiolate [46] et le formaldéhyde [47], les réactions à type de phénomène d'Arthus [15,30], et les abcès récurrents stériles [13] induits par les anatoxines. Les autres sont généralisées, comme certaines urticaires, certains angioedèmes et certaines éruptions non urticariennes liées aux injections de vaccins contenant de la gélatine [32,50,57].…”

Section: -104unclassified

“…Des réactions anaphylactiques ont donc été rapportées chez des patients non allergiques à l'oeuf, lors d'injections de vaccins contenant de l'ovalbumine et de la gélatine, ainsi que chez des patients immunisés par d'autres vaccins adsorbés sur de la gélatine (vaccins contre l'encéphalite japonaise et la varicelle, et, au Japon, vaccins associés du type DTCP/DTCPHaemophilus influenzae) [32,49,52]. Des antécédents d'allergie alimentaire à la gélatine ont été retrouvés a posteriori chez plusieurs patients, et une allergie alimentaire à la gélatine s'est développée secondairement chez 20 à 25 % des patients [49].…”

Section: La Gélatineunclassified

“…Les vaccins adsorbés sur gélatine induisent aussi des réac-tions non immédiates, de type variés (urticaire, rashs maculopapuleux, éruptions mal étiquetées) [32,50,57]. Les réactions accélérées pourraient résulter d'une HS semi-retardée, liée à des taux élevés d'IgG sériques spécifiques [50].…”

Section: La Gélatineunclassified

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Les réactions allergiques et pseudo-allergiques aux vaccins

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Immunogenicity of bioactive magnetic nanoparticles: Natural and acquired antibodies

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Avtalion

Margel

2007

J Biomedical Materials Res

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Uniform magnetic nanoparticles (MNP) were prepared by nucleation followed by controlled growth of maghemite thin films onto porcine gelatin nuclei. The formed gelatin containing MNP (Gel-MNP) were then coated with dextran (Gel-MNP-Dex) followed by human serum albumin (Gel-MNP-Dex-HSA). Since these MNP are designated for clinical applications, studies concerning the immunogenicity of their antigenic components (porcine gelatin, dextran, and HSA) have been performed in BALB-C mice. These studies demonstrated that plasma of nonimmunized mice already contains basal levels of natural antibodies against all of these antigenic components. This work also demonstrated that the conjugated gelatin is a weak immunogen: Intraperitoneal injection of the various MNP (Gel-MNP, Gel-MNP-Dex dispersed in PBS emulsified with Incomplete Freund's Adjuvant (IFA) mineral oil and Gel-MNP-Dex-HSA dispersed in PBS) did not increase significantly the acquired anti-gelatin antibody titers. Exceptional behavior was observed following immunization with Gel-MNP-Dex-HSA dispersed in PBS emulsified with IFA, which exhibited an adjuvant effect and turned gelatin into a stronger immunogen. In contrast to gelatin, the conjugated HSA and dextran were found to be strong immunogens. The possibility that the various MNP will not induce an autoimmune response as a result of their clinical use is discussed in the contest of the protective role of the natural antibodies.

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Gelatin-specific humoral and cellular immune responses in children with immediate- and nonimmediate-type reactions to live measles, mumps, rubella, and varicella vaccines☆☆☆★

Cited by 78 publications

References 18 publications

Seroprevalence of Measles- and Mumps-Specific Immunoglobulin G among Japanese Healthcare Students Increased during 2007–2012

Seroprevalence of Measles- and Mumps-Specific Immunoglobulin G among Japanese Healthcare Students Increased during 2007–2012

Les réactions allergiques et pseudo-allergiques aux vaccins

Immunogenicity of bioactive magnetic nanoparticles: Natural and acquired antibodies

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Gelatin-specific humoral and cellular immune responses in children with immediate- and nonimmediate-type reactions to live measles, mumps, rubella, and varicella vaccines☆☆☆★

Cited by 78 publications

References 18 publications

Seroprevalence of Measles- and Mumps-Specific Immunoglobulin G among Japanese Healthcare Students Increased during 2007&ndash;2012

Seroprevalence of Measles- and Mumps-Specific Immunoglobulin G among Japanese Healthcare Students Increased during 2007&ndash;2012

Les réactions allergiques et pseudo-allergiques aux vaccins

Immunogenicity of bioactive magnetic nanoparticles: Natural and acquired antibodies

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Product

Resources

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Seroprevalence of Measles- and Mumps-Specific Immunoglobulin G among Japanese Healthcare Students Increased during 2007–2012

Seroprevalence of Measles- and Mumps-Specific Immunoglobulin G among Japanese Healthcare Students Increased during 2007–2012