Gelatin Microspheres Loaded with Wharton's Jelly Mesenchymal Stem Cells Promote Acute Full-Thickness Skin Wound Healing and Regeneration in Mice

Jiao, Yiren; Niu, Yongxia; Chen, Xiaolin; Luo, Mingxun; Huang, Sunxing; Cao, Tianqi; Shi, Guang; Wei, Aisheng; Huang, Junjiu

doi:10.1089/wound.2022.0034

Cited by 2 publications

(2 citation statements)

References 56 publications

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“…The CCK‐8 Detection Kit (40203ES88; Yeasen) was employed to assess cell viability and proliferation ability. The absorbance of the samples was measured at a wavelength of 450 nm using a microplate reader (EPOCH2NS; BioTek), following established protocols 57 …”

Section: Methodsmentioning

confidence: 99%

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Three‐dimensional printed Zn₂SiO₄/sodium alginate composite scaffold with multiple biological functions for tendon‐to‐bone repair

Wang,

Jiao,

Zeng

et al. 2023

MedComm – Biomaterials and Applications

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The intricate nature of the tendon–bone interface poses significant challenges for current surgical methods aimed at repairing tendon–bone interface injuries. Despite notable progress in surgical techniques, these methods continue to grapple with hurdles such as complications and suboptimal healing effects. In this study, we prepared a three‐dimensional‐printed composite scaffold by incorporating bioactive ceramic zinc silicate (Zn2SiO4) into sodium alginate (SA) hydrogel. The physicochemical properties and mechanical strength of the SA hydrogel scaffold composited with Zn2SiO4 (ZnSi/SA) were investigated in vitro. Impressively, the 0.5‐ZnSi/SA scaffold exhibited a sustained release of Zn and Si ions, while exhibiting mechanical properties compatible with tendon–bone interface repair. Moreover, cell viability, cell migration, and osteogenic differentiation assay results showed that 0.5‐ZnSi/SA scaffold facilitated the viability, mobility, and osteogenic differentiation of bone marrow stromal cells. In parallel, assessments of cell viability, cell migration, and tendon differentiation indicated that 0.5‐ZnSi/SA scaffold promoted the viability, migration, and tenogenic differentiation of tendon stem/progenitor cells. Moreover, cell viability, cell migration, and tube formation assay results demonstrated that 0.5‐ZnSi/SA scaffold enhanced the viability, migration rate, and angiogenic performance of human umbilical vein endothelial cells. Collectively, our findings suggest a promising therapeutic avenue employing ZnSi/SA scaffold for tendon–bone interface healing.

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Section: Methodsmentioning

confidence: 99%

“…The absorbance of the samples was measured at a wavelength of 450 nm using a microplate reader (EPOCH2NS; BioTek), following established protocols. 57…”

Section: Cell Proliferation Assaymentioning

confidence: 99%

Three‐dimensional printed Zn₂SiO₄/sodium alginate composite scaffold with multiple biological functions for tendon‐to‐bone repair

Wang,

Jiao,

Zeng

et al. 2023

MedComm – Biomaterials and Applications

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Exploring the Efficacy of Hydroxybenzoic Acid Derivatives in Mitigating Jellyfish Toxin-Induced Skin Damage: Insights into Protective and Reparative Mechanisms

Geng,

Li,

Teng

et al. 2024

Marine Drugs

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The escalation of jellyfish stings has drawn attention to severe skin reactions, underscoring the necessity for novel treatments. This investigation assesses the potential of hydroxybenzoic acid derivatives, specifically protocatechuic acid (PCA) and gentisic acid (DHB), for alleviating Nemopilema nomurai Nematocyst Venom (NnNV)-induced injuries. By employing an in vivo mouse model, the study delves into the therapeutic efficacy of these compounds. Through a combination of ELISA and Western blot analyses, histological examinations, and molecular assays, the study scrutinizes the inflammatory response, assesses skin damage and repair mechanisms, and investigates the compounds’ ability to counteract venom effects. Our findings indicate that PCA and DHB significantly mitigate inflammation by modulating critical cytokines and pathways, altering collagen ratios through topical application, and enhancing VEGF and bFGF levels. Furthermore, both compounds demonstrate potential in neutralizing NnNV toxicity by inhibiting metalloproteinases and phospholipase-A2, showcasing the viability of small-molecule compounds in managing toxin-induced injuries.

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Gelatin Microspheres Loaded with Wharton's Jelly Mesenchymal Stem Cells Promote Acute Full-Thickness Skin Wound Healing and Regeneration in Mice

Cited by 2 publications

References 56 publications

Three‐dimensional printed Zn₂SiO₄/sodium alginate composite scaffold with multiple biological functions for tendon‐to‐bone repair

Three‐dimensional printed Zn₂SiO₄/sodium alginate composite scaffold with multiple biological functions for tendon‐to‐bone repair

Exploring the Efficacy of Hydroxybenzoic Acid Derivatives in Mitigating Jellyfish Toxin-Induced Skin Damage: Insights into Protective and Reparative Mechanisms

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Gelatin Microspheres Loaded with Wharton's Jelly Mesenchymal Stem Cells Promote Acute Full-Thickness Skin Wound Healing and Regeneration in Mice

Cited by 2 publications

References 56 publications

Three‐dimensional printed Zn2SiO4/sodium alginate composite scaffold with multiple biological functions for tendon‐to‐bone repair

Three‐dimensional printed Zn2SiO4/sodium alginate composite scaffold with multiple biological functions for tendon‐to‐bone repair

Exploring the Efficacy of Hydroxybenzoic Acid Derivatives in Mitigating Jellyfish Toxin-Induced Skin Damage: Insights into Protective and Reparative Mechanisms

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Product

Resources

About

Three‐dimensional printed Zn₂SiO₄/sodium alginate composite scaffold with multiple biological functions for tendon‐to‐bone repair

Three‐dimensional printed Zn₂SiO₄/sodium alginate composite scaffold with multiple biological functions for tendon‐to‐bone repair