Gelatin microsphere cocktails of different sizes for the controlled release of anticancer drugs

Narayani, Raj I.; Rao, K. Panduranga

doi:10.1016/s0378-5173(96)04685-6

Cited by 40 publications

(21 citation statements)

References 6 publications

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“…Taking inspiration from the study by Berkland et al 22 and Narayani and Panduranga Roa, 24 we demonstrate that the mathematical model presented in this paper can be used to design such systems. Figure 7 shows a convex, concave and nearly zero order release profiles, all calculated using the mathematical model and the parameters that were used in section 3.…”

Section: Design Of Microspheres To Achieve Desired Profile Of Drug Rementioning

confidence: 59%

A Mechanistic Model for Acidic Drug Release Using Microspheres Made of PLGA 50:50

Sevim

Pan

2016

Mol. Pharmaceutics

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Polyester microspheres are extensively studied for controlled release drug delivery devices, and many models have been developed to describe drug release from the bulk polymer.However, the interaction between drugs and polymers is ignored in most of the existing mathematical models. This paper presents a mechanistic model which captures the interplay between acidic drugs and bioresorbable polyesters. The model considers the autocatalytic effect on polymer degradation arising from carboxylic acid end groups of oligomers and drug molecules. Hence, the enhancing effect of acidic drug on the rate of degradation was fully considered. On the other hand the drug release from polyester microspheres is controlled by drug diffusion from polymer matrix. The drug diffusion coefficient depends strongly on the level of degradation of the polymer. This effect is also included in the model. It is shown that the model can effectively predict experimental data in the literature for both polymer degradation and drug release. Furthermore the model is used to design different systems of microspheres which release drugs with either a zero order profile or burst followed by zero order release profile.

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Section: Design Of Microspheres To Achieve Desired Profile Of Drug Rementioning

confidence: 59%

A Mechanistic Model for Acidic Drug Release Using Microspheres Made of PLGA 50:50

Sevim

Pan

2016

Mol. Pharmaceutics

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“…Bezemer et al produced linear lysozyme release over 25 days from PEG-PBT microspheres having a bimodal size distribution dominated by 50-µm and 110-µm particles (in essence a combination of two sizes) [21]. Finally, Narayani et al combined gelatin microspheres of various size ranges producing zero-order release of methotrexate [128]. In general, however, zero-order release has been difficult to achieve with simple microsphere systems.…”

Section: In-vitro Release From Mixtures Of Uniform Microspheresmentioning

confidence: 99%

“…Based on the different shapes of the uniform PPF microsphere release profiles, and given the reproducibility of the PPF methodology for uniform microsphere fabrication, it was reasoned that it may be possible to modulate release kinetics in a desired fashion by mixing appropriate proportions of two or more uniform microsphere preparations (Figure 2.11) [21][22]128]. To investigate the generality of this hypothesis, we mixed uniform microspheres of different sizes to generate zero-order release of rhodamine and the clinically relevant NSAID, piroxicam.…”

Section: In-vitro Release From Mixtures Of Uniform Microspheresmentioning

confidence: 99%

Microspheres for Drug Delivery

Kim

Pack

2006

BioMEMS and Biomedical Nanotechnology

115

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“…However, the main preparation parameters vary widely in the literature. When microspheres are produced, these parameters can influence particle size and the microsphere's size is very important to define the administration route [15,16] and the liberation rates [16] . Because of this, in this work, we designed experiments to determine the most important parameters that can influence particle size.…”

Section: Introductionmentioning

confidence: 99%

Potential doxorubicin delivery system based on magnetic gelatin microspheres crosslinked with sugars

2018

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ObstractThe preparation and characterization of magnetic microspheres based on gelatin for use in drug delivery systems are reported. Sugars were employed as crosslinking agents and type A gelatin and type B gelatin were compared to prepare microspheres by water-in-oil emulsion. The influence of gelatin and sucrose concentration, temperature and stirring speed on microbeads' characteristics was studied. The gelatin concentration and stirring speed were the parameters directly associated with the particle sizes. We found no relevant difference between the use of type A and type B gelatin. In addition, the gelatin crosslinking study revealed that sucrose is not a crosslinking agent but fructose can crosslink the protein chains when the reaction medium has pH 9. The size of the microspheres varied from 5 to 60 μm as measured by optical microscopic images. Doxorubicin adsorption and release were successfully performed using the microspheres crosslinked with fructose under the action of an external magnetic field. It was observed that the microspheres absorbed 69% of the doxorubicin that was in solution. After 24 h, about 45% of the DOX was displaced from microspheres to saline medium in the free form in the solution.

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Gelatin microsphere cocktails of different sizes for the controlled release of anticancer drugs

Cited by 40 publications

References 6 publications

A Mechanistic Model for Acidic Drug Release Using Microspheres Made of PLGA 50:50

A Mechanistic Model for Acidic Drug Release Using Microspheres Made of PLGA 50:50

Microspheres for Drug Delivery

Potential doxorubicin delivery system based on magnetic gelatin microspheres crosslinked with sugars

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