Gelatin microparticles containing propolis obtained by spray-drying technique: preparation and characterization

Bruschi, Marcos Luciano; Cardoso, Mara Lane Carvalho; Lucchesi, Maria Beatriz Bastos; Gremião, Maria Palmira Daflon

doi:10.1016/s0378-5173(03)00386-7

Cited by 181 publications

(113 citation statements)

References 39 publications

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“…The difference in solubility between the ethanol extractions was not significant. Therefore, BP showed a greater ethanol affinity when compared with water, denoting a similarity between BP and propolis (Bruschi et al, 2003;Bruschi et al, 2006).…”

Section: Residue Solubility and Film Formationmentioning

confidence: 97%

“…Therefore, the addition of a polymeric adjuvant (gelatin or ethylcellulose) was considered. These polymers display different solubility in water and are used in preparations containing propolis (Bruschi et al, 2003;Avanço, Bruschi, 2008).…”

Section: Residue Solubility and Film Formationmentioning

confidence: 99%

“…It has a complex chemical composition and typically consists of gums, resins, bee wax, volatile substances, phenol substances, and impurities (Ghisalberti, 1979;Burdock, 1998). It has been utilized by mankind, since ancient times due to its antimicrobial, fungicidal, antiviral, antiulcer, immunostimulating, hypotensive, inflammatory, antioxidant, and cytostatic activities (Burdock, 1998;Isla et al, 2001;Nagai et al, 2001;Bruschi et al, 2003;Marcucci, 2006;Sforcin, Bankova, 2011;Pereira, Bruschi, 2012). The therapeutic properties of propolis are normally attributed to its ethanolic extracts, which can be used as the eventual dosage form or incorporated into foods, beverages, medicines or cosmetics (Burdock, 1998;Bruschi et al, 2003;Avanço, Bruschi, 2008).…”

Section: Introductionmentioning

confidence: 99%

“…It has been utilized by mankind, since ancient times due to its antimicrobial, fungicidal, antiviral, antiulcer, immunostimulating, hypotensive, inflammatory, antioxidant, and cytostatic activities (Burdock, 1998;Isla et al, 2001;Nagai et al, 2001;Bruschi et al, 2003;Marcucci, 2006;Sforcin, Bankova, 2011;Pereira, Bruschi, 2012). The therapeutic properties of propolis are normally attributed to its ethanolic extracts, which can be used as the eventual dosage form or incorporated into foods, beverages, medicines or cosmetics (Burdock, 1998;Bruschi et al, 2003;Avanço, Bruschi, 2008). During the extraction process of propolis constituents, the solvent carries a smaller amount of substances and a greater part is to be dissolved, constituting the residue or (BP) that is not utilized and normally disposed (Bruschi et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

“…The therapeutic properties of propolis are normally attributed to its ethanolic extracts, which can be used as the eventual dosage form or incorporated into foods, beverages, medicines or cosmetics (Burdock, 1998;Bruschi et al, 2003;Avanço, Bruschi, 2008). During the extraction process of propolis constituents, the solvent carries a smaller amount of substances and a greater part is to be dissolved, constituting the residue or (BP) that is not utilized and normally disposed (Bruschi et al, 2002). However, BP possesses in its composition several substances such as wax, resins and gums, which may be important in the development of micro/nanostructured compounds (Bruschi et al, 2003;Hasirci et al, 2011;Sulaiman et al, 2011;Bodini et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Pharmaceutical films made from the waste material from the preparation of propolis extracts: development and characterization

Toledo

Bavato

Rosseto

et al. 2015

Braz. J. Pharm. Sci.

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This study investigated the development and characterized the physicochemical properties of films obtained from by-products (BP) from the preparation of propolis extracts. Films were produced in the presence and absence of a polymeric adjuvant (gelatin or ethylcellulose) and propylene glycol by a solvent casting method. Density, surface topography by scanning electron microscopy, mechanical properties (folding endurance, tensile strength and percentage elongation), water vapour permeability (WVP), moisture uptake capacity, thermogravimetry, differential scanning calorimetry and Fourier transform infrared spectroscopy (FTIR) were determined. The films were a transparent, light greenishyellow colour, with a uniform surface, and were flexible and easy to handle. The thickness and density of the preparations indicated that the compounds were homogeneously dispersed throughout the film. Mechanical properties were influenced by the film composition; films containing gelatin were more resistant to stress, while those containing ethylcellulose were more flexible. Increasing the adjuvant concentration decreased the elasticity and the rupture resistance, but increased the moisture uptake capacity and WVP of the formulations. BP was thermally stable as were the films. FTIR tests suggested interactions between BP and the adjuvants. This work could contribute to the utilization of BP to prepare films for food and pharmaceutical uses Uniterms: Propolis/byproducts. Propolis/use of waste material/films development. Films/propolis byproducts/physicochemical properties. Polymers. Ethylcellulose. Gelatin.Este estudo investigou o desenvolvimento e as características físico-químicas de filmes obtidos com o resíduo (BP), normalmente descartado, advindo da preparação de extratos de própolis. Os filmes foram produzidos com e sem adjuvantes poliméricos (gelatina ou etilcelulose) e propilenoglicol, pelo método de evaporação de solvente. Foram determinadas a densidade, a topografia de superfície usando microscopia eletrônica de varredura, as propriedades mecânicas (resistência à dobra, tensão e elongação), transmissão de vapor de água (WVP), capacidade de absorção de umidade, termogravimetria, calorimetria exploratória diferencial e espectroscopia de infravermelho com transformada de Fourier (FTIR). Os filmes demonstraram coloração verde-amarelada, transparência, uniformidade de superfície, homogeneidade, flexibilidade e fácil manuseio. A espessura e a densidade das preparações indicaram que os compostos estavam dispersos de forma homogênea. As propriedades mecânicas foram influenciadas pela composição dos filmes e aqueles que continham gelatina apresentaram-se mais resistentes enquanto os compostos por etilcelulose demonstraram maior flexibilidade. Com o aumento da concentração polimérica, a resistência e a elasticidade diminuíam, porém aumentou a capacidade de absorção de água e a WVP das formulações. BP apresentou estabilidade térmica assim como os filmes. Os testes de FTIR sugeriram interações entre o BP e os adjuvantes utilizados. Es...

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Section: Residue Solubility and Film Formationmentioning

confidence: 97%

Section: Residue Solubility and Film Formationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Pharmaceutical films made from the waste material from the preparation of propolis extracts: development and characterization

Toledo

Bavato

Rosseto

et al. 2015

Braz. J. Pharm. Sci.

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Astaxanthin from Haematococcus pluvialis Microencapsulated by Spray Drying: Characterization and Antioxidant Activity

Zhao

Liu

Zhang

et al. 2018

J Americ Oil Chem Soc

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Astaxanthin (AX) is an unstable functional food ingredient. A stable AX powder was developed and its characteristics (such as moisture content, bulk density, solubility, repose angle, and morphology) and antioxidant activity were evaluated. The microencapsulated AX powder was produced by spray drying using maltodextrin (MD)-gelatin and the parameters were optimized by response surface methodology. The results revealed that an optimal microencapsulation process has a ratio of MD to gelatin of 2.1:1, a ratio of wall to core materials of 5.9:1, and a ratio of glycerol monostearate to sucrose fatty-acid ester of 1.1:1. The AX encapsulation yield and encapsulation efficiency were 38.02% and 71.76%, respectively. AX microcapsules had a lower moisture content and bulk density, greater solubility, and good flowability. AX microcapsules showed antioxidant activities greater than Vitamin C, which indicated that the antioxidant activity of AX was not lost. AX microcapsule micrographs showed almost no cracks or fissures on the surface of microcapsules produced by spray drying under the optimal conditions.

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Gelatin supports with immobilized laccase as sustainable biocatalysts for water treatment

Harguindeguy

Antonelli

Belleville

et al. 2020

J of Applied Polymer Sci

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Millimeter‐size beads of gelatin are manufactured by dripping process to give enzyme supports qualified for micropollutants biodegradation in alternative wastewater treatment. The bead diameter is dependent on the tip diameter, the gelatin solution viscosity and the swelling of polymer chains in the collecting bath. Chemical crosslinking was performed with glutaraldehyde using optimal concentration to give mechanical and thermal properties suitable for application in stirred reactor in aqueous medium. Laccases from Trametes versicolor are grafted on the gelatin beads with glutaraldehyde. Sixty percentage of the initial enzymatic activity, evaluated by the oxidation of 2′‐Azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonic acid)diammonium salt (ABTS) is maintained after 10 successive cycles of reaction. Thermal stability at 60°C of immobilized biocatalysts is improved when compared to free enzymes (45% vs 10% of relative activity after 6 h of incubation). The simplicity of the procedure to form gelatin beads and their properties make them promising bio‐based and biodegradable support for enzyme immobilization.

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Gelatin microparticles containing propolis obtained by spray-drying technique: preparation and characterization

Cited by 181 publications

References 39 publications

Pharmaceutical films made from the waste material from the preparation of propolis extracts: development and characterization

Pharmaceutical films made from the waste material from the preparation of propolis extracts: development and characterization

Astaxanthin from Haematococcus pluvialis Microencapsulated by Spray Drying: Characterization and Antioxidant Activity

Gelatin supports with immobilized laccase as sustainable biocatalysts for water treatment

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