Gelatin microcapsules for enhanced microwave tumor hyperthermia

Du, Qijun; Fu, Changhui; Tie, Jian Ke; Liu, Tianlong; Li, Linlin; Ren, Xiangling; Huang, Zhongbing; Liu, Huiyu; Tang, Fangqiong; Li, Li; Meng, Xianwei

doi:10.1039/c4nr07104b

Cited by 42 publications

(31 citation statements)

References 55 publications

(77 reference statements)

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“…Haemolysis rate is an important parameter for evaluating blood compatibility, and less than 5% haemolysis is regarded as a nontoxic effect level [63]. Nearly no haemolysis was observed for the negative control (−), and complete haemolysis was observed for the positive control (+).…”

Section: Resultsmentioning

confidence: 99%

Inhibitory Effects of Ginsenoside Ro on the Growth of B16F10 Melanoma via Its Metabolites

Zheng

Shuhua²,

Wang

et al. 2019

Molecules

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Ginsenoside Ro (Ro), a major saponin derived and isolated from Panax ginseng C.A. Meyer, exerts multiple biological activities. However, the anti-tumour efficacy of Ro remains unclear because of its poor in vitro effects. In this study, we confirmed that Ro has no anti-tumour activity in vitro. We explored the anti-tumour activity of Ro in vivo in B16F10 tumour-bearing mice. The results revealed that Ro considerably suppressed tumour growth with no significant side effects on immune organs and body weight. Zingibroside R1, chikusetsusaponin IVa, and calenduloside E, three metabolites of Ro, were detected in the plasma of Ro-treated tumour-bearing mice and showed excellent anti-tumour effects as well as anti-angiogenic activity. The results suggest that the metabolites play important roles in the anti-tumour efficacy of Ro in vivo. Additionally, the haemolysis test demonstrated that Ro has good biocompatibility. Taken together, the findings of this study demonstrate that Ro markedly suppresses the tumour growth of B16F10-transplanted tumours in vivo, and its anti-tumour effects are based on the biological activity of its metabolites. The anti-tumour efficacy of these metabolites is due, at least in part, to its anti-angiogenic activity.

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Section: Resultsmentioning

confidence: 99%

Inhibitory Effects of Ginsenoside Ro on the Growth of B16F10 Melanoma via Its Metabolites

Zheng

Shuhua²,

Wang

et al. 2019

Molecules

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“…The confinement effect of the nanoparticles can be used to accelerate the movement of encapsulated ions or molecules under the MW field, producing more heat and significantly increasing the surrounding temperature. This effect has been used to enhance tumor ablation [7, 29]. NaCl, a known ideal MW-sensitive material, can be loaded into the PLGA nanoparticles by a simple microemulsion method.…”

Section: Resultsmentioning

confidence: 99%

“…Non-lethal and insufficient thermal delivery is the most common cause for tumor progression after MW ablation, especially in the peripheral tumor area with lower temperature [5, 6]. Recently, different kinds of MW-sensitive agents and combined therapies of MW ablation and chemotherapy have been developed to enhance the therapeutic outcomes of MW ablation [7–10]. Nevertheless, all those efforts failed to solve the high recurrence in the peri-ablation areas of tumors.…”

Section: Introductionmentioning

confidence: 99%

Amplified intracellular Ca2+ for synergistic anti-tumor therapy of microwave ablation and chemotherapy

Dou

et al. 2019

J Nanobiotechnol

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BackgroundDeveloping new strategies to reduce the output power of microwave (MW) ablation while keeping anti-tumor effect are highly desirable for the simultaneous achievement of effective tumor killing and avoidance of complications. We find that mild MW irradiation can significantly increase intracellular Ca2+ concentration in the presence of doxorubicin hydrochloride (DOX) and thus induce massive tumor cell apoptosis. Herein, we designed a synergistic nanoplatform that not only amplifies the intracellular Ca2+ concentration and induce cell death under mild MW irradiation but also avoids the side effect of thermal ablation and chemotherapy.ResultsThe as-made NaCl–DOX@PLGA nanoplatform selectively elevates the temperature of tumor tissue distributed with nanoparticles under low-output MW, which further prompts the release of DOX from the PLGA nanoparticles and tumor cellular uptake of DOX. More importantly, its synergistic effect not only combines thermal ablation and chemotherapy, but also obviously increases the intracellular Ca2+ concentration. Changes of Ca2+ broke the homeostasis of tumor cells, decreased the mitochondrial inner membrane potential and finally induced the cascade of apoptosis under nonlethal temperature. As such, the NaCl–DOX@PLGA efficiently suppressed the tumor cell progression in vivo and in vitro under mild MW irradiation for the triple synergic effect.ConclusionsThis work provides a biocompatible and biodegradable nanoplatform with triple functions to realize the effective tumor killing in unlethal temperature. Those findings provide reliable solution to solve the bottleneck problem bothering clinics about the balance of thermal efficiency and normal tissue protection.

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“…It also results obvious cytotoxic effects on surrounding healthy tissues. Hence, a variety of microwave sensitizing nanomaterials have been developed [11][12][13][14], such as organic materials (gelatin, sodium alginate microcapsules) [15], inorganic materials [16][17][18] (zirconium dioxide hollow nanospheres [19], carbon nanotubes [20][21][22]), organic-inorganic hybrid materials (metal organic framework [23][24][25]). Amongst, synthesis methods and the targeting ability of the organic materials need to be improved [26,27].…”

Section: Introductionmentioning

confidence: 99%

Lanthanide Europium MOF Nanocomposite as the Theranostic Nanoplatform for Microwave Thermo-Chemotherapy and Fluorescence Imaging

Zhao

Zhang²,

et al. 2021

Preprint

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Backgrounds: Microwave sensitization nanoplatform, integrating multiple functional units for improving tumor selectivity, is of great significance for clinical tumor microwave therapy. Lanthanide europium metal organic framework materials (EuMOF) are expected to be a theranostic nanoplatform owing to its specific luminescent properties and microwave sensitization properties. However, it is difficult to be applied to complex biological systems for EuMOF due to its rapid degradation induced by the solvent molecular and ionic environment. In this work, a luminescent EuMOF nanocomposite (EuMOF@ZIF/AP-PEG, named EZAP) was designed, which brought the multifunctional characteristics of microwave sensitization, fluorescence imaging and drug loading. Results Lamellar EuMOF was synthesized by a hydrothermal method. Through the charge adsorption mechanism, the zeolite imidazole framework (ZIF) structure was densely assembled on the surface of EuMOF to realize the protection. Then, through in-situ apatinib drug loading and PEG modification, EZAP nanocomposite was finally obtained. Apatinib (AP) was a kind of chemotherapy drug approved by Food and Drug Administration for clinical use. PEG modification increased long-term circulation of EZAP nanocomposite. The physical and chemical structure and properties of EuMOF@ZIF (EZ) were systematically represented, indicating the successful synthesis of the nanocomposite. The toxic and side effects were negligible at a safe dose. The growth of human liver cancer cells and murine liver cancer cells in vitro was significantly inhibited, and the combined microwave-thermal therapy and chemotherapy in vivo achieved high anti-cancer efficacy. Moreover, EZAP nanocomposite possessed bright red fluorescence, which had good ability for tumor imaging in tumor-bearing mice in vivo. Conclusion Therefore, EZAP nanocomposite showed high microwave sensitization, excellent fluorescence properties and good drug loading capacity, establishing a promising theranostic nanoplatform for tumor therapy and fluorescence imaging. This work proposes a unique strategy to design for the first time a multifunctional nanoplatform with lanthanide metal organic frameworks for tumor treatment and diagnosis in the biological application.

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Gelatin microcapsules for enhanced microwave tumor hyperthermia

Cited by 42 publications

References 55 publications

Inhibitory Effects of Ginsenoside Ro on the Growth of B16F10 Melanoma via Its Metabolites

Inhibitory Effects of Ginsenoside Ro on the Growth of B16F10 Melanoma via Its Metabolites

Amplified intracellular Ca2+ for synergistic anti-tumor therapy of microwave ablation and chemotherapy

Lanthanide Europium MOF Nanocomposite as the Theranostic Nanoplatform for Microwave Thermo-Chemotherapy and Fluorescence Imaging

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