Gelatin gelcasting of ceramic components

Vandeperre, Luc; Wilde, A.-M. de; Luyten, J.

doi:10.1016/s0924-0136(02)00862-2

Cited by 70 publications

(37 citation statements)

References 9 publications

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“…Gelatin is a natural polymer with viscosity dependent upon the ambient temperature under certain conditions it can act as a binder for particles to form mechanically stable green bodies [ [23][24][25]. The effect of gelatin concentration on the ability to produce a foamed structure, of PSrBG, was investigated using 0.2 ml of surfactant and scaffolds were sintered for 3 h at 690°C.…”

Section: Gelatin Concentration For Gelationmentioning

confidence: 99%

Highly degradable porous melt-derived bioactive glass foam scaffolds for bone regeneration

et al. 2017

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a b s t r a c tA challenge in using bioactive melt-derived glass in bone regeneration is to produce scaffolds with interconnected pores while maintaining the amorphous nature of the glass and its associated bioactivity. Here we introduce a method for creating porous melt-derived bioactive glass foam scaffolds with low silica content and report in vitro and preliminary in vivo data. The gel-cast foaming process was adapted, employing temperature controlled gelation of gelatin, rather than the in situ acrylic polymerisation used previously. To form a 3D construct from melt derived glasses, particles must be fused via thermal processing, termed sintering. The original Bioglass Ò 45S5 composition crystallises upon sintering, altering its bioactivity, due to the temperature difference between the glass transition temperature and the crystallisation onset being small. Here, we optimised and compared scaffolds from three glass compositions, ICIE16, PSrBG and 13-93, which were selected due to their widened sintering windows. Amorphous scaffolds with modal pore interconnect diameters between 100-150 mm and porosities of 75% had compressive strengths of 3.4 ± 0.3 MPa, 8.4 ± 0.8 MPa and 15.3 ± 1.8 MPa, for ICIE16, PSrBG and 13-93 respectively. These porosities and compressive strength values are within the range of cancellous bone, and greater than previously reported foamed scaffolds. Dental pulp stem cells attached to the scaffold surfaces during in vitro culture and were viable. In vivo, the scaffolds were found to regenerate bone in a rabbit model according to X-ray micro tomography imaging. Statement of SignificanceThis manuscript describes a new method for making scaffolds from bioactive glasses using highly bioactive glass compositions. The glass compositions have lower silica content that those that have been previously made into amorphous scaffolds and they have been designed to have similar network connectivity to that of the original (and commercially used) 45S5 Bioglass. The aim was to match Bioglass' bioactivity. The scaffolds retain the amorphous nature of bioactive glass while having an open pore structure and compressive strength similar to porous bone (the original 45S5 Bioglass crystallises during sintering, which can cause reduced bioactivity or instability).The new scaffolds showed unexpectedly rapid bone regeneration in a rabbit model.

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Section: Gelatin Concentration For Gelationmentioning

confidence: 99%

Highly degradable porous melt-derived bioactive glass foam scaffolds for bone regeneration

et al. 2017

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“…Sodium dodecyl sulfate (SDS) was used as foaming agent. Polyethylene glycol (PEG, molecular weight 10,000) was added to prevent the warpage and cracking of green bodies [26].…”

Section: Sample Preparationmentioning

confidence: 99%

“…Although some less toxic monomers have been developed, it was not still a radical solution [22,23]. Hence, many research efforts were devoted to explore new natural gelling agents, such as starch [24], gelatin [25,26], proteins [27,28], and agarose [29]. Besides being environmentally friendly, they do not need atmosphere control for the polymerization of gel former.…”

Section: Introductionmentioning

confidence: 99%

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Preparation, microstructure and high temperature performances of porous γ-Y2Si2O7 by in situ foam-gelcasting using gelatin

Sun

Wan

et al. 2015

Ceramics International

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“…Gelcasting can also be used to tailor microstructure and mechanical properties for specific applications. Gelatins have been used in place of normal "gelling" agents as a low cost alternative that has more retained porosity after sintering [20].…”

Section: Introductionmentioning

confidence: 99%

Replamineform Inspired Bone Structures (RIBS) using multi-piece molds and advanced ceramic gelcasting technology

Gyger¹,

Kulkarni²,

Bruck³

et al. 2007

Materials Science and Engineering: C

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A new technology was developed for quickly, simply, and affordably creating Replamineform Inspired Bone Structures (RIBS) that combines multi-piece mold manufacturing for creating complex macroscale geometries with advanced ceramic gelcasting technology for controlling microporosity. A conventional gelcast alumina formulation was modified by adding 0-10 wt. % of fugitive carbon particles (graphitic and activated) to obtain porous microstructures during sintering. The carbon-filled gelcast alumina formulation was used to create replicas of bone structures by filling a multi-piece mold automatically generated from a 3-D image of a real bone. Both types of carbon produced total porosity levels of up to 35% that increased with carbon content in a manner that indicated residual porosity from the burned out carbon was not being consumed during sintering. However, activated carbon specimens exhibited linearly increasing percentage of closed porosity with increasing carbon content, while graphitic samples exhibited more interconnected porosity with pore channels in the range of 200 µm. The influence of porosity on mechanical properties was studied by compression tests. The tests indicated that 35% total porosity in bone replicas can decrease strength 88%, decrease stiffness 80%, and reduce total deformation 40% in comparison to bone replicas with 13% total porosity fabricated without carbon. The reduction in stiffness was consistent with a model developed from microscale finite element analysis of overlapping solid spheres that produce microstructures similar to those observed in these specimens. Furthermore, the increased porosity of the material permits axial cracks to grow and bifurcate more easily at substantially reduced deformation and load levels.

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Gelatin gelcasting of ceramic components

Cited by 70 publications

References 9 publications

Highly degradable porous melt-derived bioactive glass foam scaffolds for bone regeneration

Highly degradable porous melt-derived bioactive glass foam scaffolds for bone regeneration

Preparation, microstructure and high temperature performances of porous γ-Y2Si2O7 by in situ foam-gelcasting using gelatin

Replamineform Inspired Bone Structures (RIBS) using multi-piece molds and advanced ceramic gelcasting technology

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