Gelatin‐based sprayable foam as a skin substitute

Neumann, Petr; Zur, B.; Ehrenreich, Y.

doi:10.1002/jbm.820150105

Cited by 58 publications

(33 citation statements)

References 14 publications

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“…Developing new uses for gelatin-based hydrogels is another important area of academic research. [11] Additionally, the mechanical and chemical properties of gelatin can be modified using various kinds of crosslinking agents [12][13][14][15][16] (e.g., glutaraldehyde, genipin, and dextran dialdehyde). For example, Crescenzi et al [17] developed new gelatin-based hydrogels from high bloom purified gelatin A with/without hyaluronan by using transglutaminase-catalyzed crosslinking to form more densely connected networks that support cell regeneration.…”

Section: Introductionmentioning

confidence: 99%

Gelatin-based hydrogels for biomedical applications

2017

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Gelatin-based hydrogels derived from hydrolysis of collagen have been extensively used in pharmaceutical and medical applications because of their biocompatibility and biodegradability. For example, gelatin-based hydrogels are finding use in drug delivery and tissue engineering because they are able to promote cell adhesion and proliferation. In addition, these hydrogels can be used as wound dressings due to their attractive fluid absorbance properties. Manufacturing technologies such as ultraviolet stereolithography and two-photon polymerization can be used to prepare structures containing photosensitive gelatin-based hydrogels. This review describes the preparation of gelatin-based hydrogels and use of these materials for biomedical applications.

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Section: Introductionmentioning

confidence: 99%

Gelatin-based hydrogels for biomedical applications

2017

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“…La gélatine est obtenue par hydrolyse du collagène, ce dernier est le constituant majeur de la peau et des tissus osseux (Tabata and Ikada, 1998). La gélatine est largement utilisée dans l'industrie médicale comme pansement pour blessures, garniture absorbante ou adhésif (Neumann et al, 1981) et plus particulièrement comme matériel biopharmaceutique pour la libération contrôlée des médicaments (Fukunaka et al, 2002). La gélatine contient un total de 18 acides aminés en différentes concentrations, la liaison de ces acides forme des chaînes polypeptidiques, chaque chaîne contient environ mille acides aminés (Gomez-Guillen et al, 2002).…”

Section: Introductionunclassified

Caractérisations physicochimiques de biofilms synthétisés à partir de la pectine et de la gélatine

Gbassi¹,

Zaher²,

Yolou³

et al. 2009

International Journal of Biological and Chemical Sciences

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22 47 22 17 RESUMETrois types de biofilms à base de polymères naturels ont été préparés à partir de la pectine, un polyélectrolyte anionique, et de la gélatine, une espèce cationique. Les propriétés physicochimiques (épaisseur, perméabilité à la vapeur d'eau et pouvoir gonflant) des biofilms ont été déterminées; de même, leur morphologie a été évaluée. Au niveau micrométrique, les épaisseurs des biofilms étaient respectivement de 101,2±0,2 µm; 64,6±0,1 µm et 39,0±0,1 µm pour la gélatine, le mélange gélatine/pectine et la pectine. Le pouvoir gonflant était de 300% pour la gélatine, 215% pour le mélange gélatine/pectine et 90% pour la pectine. La perméabilité à la vapeur d'eau était de 9,20 g mm/m 2 h KPa pour la gélatine; 6,59 g mm/m 2 h KPa pour le mélange gélatine/pectine et 3,98 g mm/m 2 h KPa pour la pectine. Au niveau morphologique, des différences significatives ont été observées. Toutefois, les différents films formulés ont mis en évidence des potentialités physicochimiques intéressantes.

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“…Dressing materials having 100 kg f /cm 2 in tensile strength and 20% in elongation have been favored to graft. 19,20 The tensile strength and elongation of hydrogels under dry and wet condition are shown in Figures 2 and 3, respectively. The tensile strength of the PVA/alginate hydrogels increased as the concentration of alginate decreased and as the radiation dose increased.…”

Section: Resultsmentioning

confidence: 99%

“…Therefore, the samples could be considered as stable and durable skin substitute when they were soaked by fluid. 19,20 In vitro Cytotoxicity Test. Cytotoxicity of hydrogels crosslinked by γ-ray irradiation was evaluated on mouse fibroblast cultures.…”

Section: Resultsmentioning

confidence: 99%

Evaluations of poly(vinyl alcohol)/alginate hydrogels cross-linked by γ-ray irradiation technique

et al. 2004

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In this work, we prepared hydrogels for wound dressing from a mixture of poly(vinyl alcohol) (PVA) and alginate using the 60 Co γ-ray irradiation technique. We examined the physical properties of these hydrogels, including gelation, water absorptivity, and gel strength, to evaluate the applicability of these hydrogels for wound dressings. The biocompatibility of these hydrogels was also evaluated in vitro, in cultures of mouse fibroblasts, and in vivo, by subcutaneous implantation studies in rats. The gel content and strength increased upon increasing the radiation dose and upon decreasing the concentration of alginate. The degree of swelling was inversely proportional to the gel content and strength. The degree of cytotoxicity of the γ-ray-treated hydrogels was ca. 60% compared to the (-) control (serum) after 1 day of incubation. When the incubations were prolonged up to 2 days, the toxicity of all the samples decreased remarkably and reached that of the control. Subcutaneous implantation studies in rats indicated that foreign body reactions occurring around the implanted hydrogels were moderate and became minimal upon increasing the implantation time.

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Gelatin‐based sprayable foam as a skin substitute

Cited by 58 publications

References 14 publications

Gelatin-based hydrogels for biomedical applications

Gelatin-based hydrogels for biomedical applications

Caractérisations physicochimiques de biofilms synthétisés à partir de la pectine et de la gélatine

Evaluations of poly(vinyl alcohol)/alginate hydrogels cross-linked by γ-ray irradiation technique

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