Gelatin-based scaffolds: An intuitive support structure for regenerative therapy

Rashid, Adib Bin; Showva, Nazmir-Nur; Hoque, Enamul

doi:10.1016/j.cobme.2023.100452

Cited by 11 publications

(7 citation statements)

References 51 publications

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“…Polmer nano composite are significantly utilized for biomedical applications [ [16] , [17] , [152] ]. Table 10 lists a variety of polymer-based composites that are utilized in biomedical applications.…”

Section: Applications Of Nanotechnology-enhanced Fiber Reinforced Pol...mentioning

confidence: 99%

“…This classification primarily includes single-component oxide aerogels and composites like SiO 2 , Al 2 O 3 , and ZrO 2 , as well as multi-component oxide aerogels and composites such as SiO 2 –Al 2 O 2 and SiO 2 –ZrO 2 [ 16 ]. Gelatin-based biomaterials for various applications were studied by Rashid et al [ 17 ]. Recently, much focus has been directed toward adding nano-sized fillers into composites.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Nanotechnology-enhanced fiber-reinforced polymer composites: Recent advancements on processing techniques and applications

Rashid,

Haque,

Islam

et al. 2024

Heliyon

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Section: Applications Of Nanotechnology-enhanced Fiber Reinforced Pol...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Nanotechnology-enhanced fiber-reinforced polymer composites: Recent advancements on processing techniques and applications

Rashid,

Haque,

Islam

et al. 2024

Heliyon

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“…Another relevant, collagen-based, well-known biomaterial for the production of freezedried sponges for tissue regeneration is gelatin [72,[82][83][84][85][86][87][88]. Gelatin is a heterogeneous mixture of water-soluble proteins originating from collagen that is commonly used in medical applications due to its biocompatibility and biodegradation [84,85,87,89].…”

Section: Freeze-dried Collagen-based Sponges In Biomedical Engineeringmentioning

confidence: 99%

Freeze-Drying Process for the Fabrication of Collagen-Based Sponges as Medical Devices in Biomedical Engineering

Katrilaka,

Karipidou,

Petrou

et al. 2023

Preprint

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Freeze-drying is a well-established process in biomedical engineering for the fabrication of three-dimensional open-porous medical devices, especially those based on biopolymers. One of the most used biopolymers in this field is collagen, the most abundant protein in the human body and the main component of the extracellular-matrix, as well as its derivatives. Freeze-dried collagen-based sponges with a wide variety of attributes can be produced by design and have led to a wide range of successful commercial medical devices, foremost for dental, orthopedic, hemostatic and neuronal applications. However, this is still considered a high-cost and time-consuming process that is often used in a non-optimized manner. By combining advances in other technological fields, the opportunity arises to further evolve this process in a sustainable manner, and optimize the resulting products as well as create new opportunities in this field.

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“…Gel presents an almost identical composition to collagen, the main component of the native extracellular matrix (ECM). It contains the Arg–Gly–Asp (RGD)-like sequence that promotes cell adhesion and migration [ 17 ] and enhances wound healing rate [ 18 , 19 ]. It has been proved that when Gel and CS are blended, the structure formed can affect the polycationic CS interaction with the anionic cell surface.…”

Section: Introductionmentioning

confidence: 99%

3D-Printed Chitosan-Based Scaffolds with Scutellariae baicalensis Extract for Dental Applications

Paczkowska-Walendowska,

Koumentakou,

Lazaridou

et al. 2024

Pharmaceutics

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The plant material Scutellariae baicalensis radix, which is rich in flavones (baicalin), possesses antibacterial, antifungal, antioxidant, and anti-inflammatory properties. This work aimed to develop a 3D-printed chitosan-based hydrogel rich in Scutellariae baicalensis extract as an innovative approach for the personalized treatment of periodontal diseases. Chitosan-based hydrogels were prepared, and the printability of the prepared hydrogels was determined. The hydrogel with 2.5% w/v of high molecular-weight chitosan (CS), 2% w/v gelatin (Gel), and 10% w/w of extract (Ex) presented the best printability, producing smooth and uniform scaffolds. It was proved that the CS/Gel/Ex hydrogel was stabilized by hydrogen bonds and remained in amorphous dispersion in the 3D-printed structures (confirmed by ATR-FTIR and XRPD). Due to the amorphization of the active substance, a significant increase in the release of baicalin in vitro was observed. It was demonstrated that there was an initial burst release and a continuous release profile (n = 3). Higuchi kinetic was the most likely baicalin release kinetic. The second fit, the Korsmeyer–Peppas kinetics model, showed coupled diffusion of the active ingredient in the hydrated matrix and polymer relaxation regulated release, with n values ranging from 0.45 to 0.89. The anti-inflammatory properties of 3D-printed scaffolds were assessed as the ability to inhibit the activity of the hyaluronidase enzyme. Activity was assessed as IC50 = 63.57 ± 4.98 mg hydrogel/mL (n = 6). Cytotoxicity tests demonstrated the biocompatibility of the material. After 24 h of exposure to the 2.5CS/2Gel/10Ex scaffold, fibroblasts migrated toward the scratch, closed the “wound” by 97.1%, and significantly accelerated the wound healing process. The results render the 3D-printed CS/Gel/extract scaffolds as potential candidates for treating periodontal diseases.

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Gelatin-based scaffolds: An intuitive support structure for regenerative therapy

Cited by 11 publications

References 51 publications

Nanotechnology-enhanced fiber-reinforced polymer composites: Recent advancements on processing techniques and applications

Nanotechnology-enhanced fiber-reinforced polymer composites: Recent advancements on processing techniques and applications

Freeze-Drying Process for the Fabrication of Collagen-Based Sponges as Medical Devices in Biomedical Engineering

3D-Printed Chitosan-Based Scaffolds with Scutellariae baicalensis Extract for Dental Applications

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