Gelatin/alginate-based microspheres with sphere-in-capsule structure for spatiotemporal manipulative drug release in gastrointestinal tract

Long, Tao; Tan, Weiwei; Tian, Xiangmin; Zong-jian, Tang; Hu, Kejia; Ge, Liming; Mu, Changdao; Li, Xinying; Xu, Yongbin; Zhao, Lei; Li, Defu

doi:10.1016/j.ijbiomac.2022.12.040

Cited by 14 publications

(5 citation statements)

References 52 publications

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“…The drug was slowly diffused and released due to the swelling of the microspheres until 16 days. The structure of the microspheres was then greatly disassembled, causing the drug to undergo secondary release as the hydrogel structure slips [ 43 , 44 ]. Microspheres with sustained release capability are especially suitable for drug delivery in long-term clinical treatment operations to control the release of locally delivered drugs and improve the treatment efficiency [ 45 ].…”

Section: Resultsmentioning

confidence: 99%

In Vitro Characterizations of Post-Crosslinked Gelatin-Based Microspheres Modified by Phosphatidylcholine or Diammonium Phosphate as Antibiotic Delivery Vehicles

Chang

Chen

et al. 2023

Polymers

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Hydrogel-based microspheres prepared by emulsification have been widely used as drug carriers, but biocompatibility remains a challenging issue. In this study, gelatin was used as the water phase, paraffin oil was used as the oil phase, and Span 80 was used as the surfactant. Microspheres were prepared using a water-in-oil (W/O) emulsification. Diammonium phosphate (DAP) or phosphatidylcholine (PC) were further used to improve the biocompatibility of post-crosslinked gelatin microspheres. The biocompatibility of DAP-modified microspheres (0.5–10 wt.%) was better than that of PC (5 wt.%). The microspheres soaked in phosphate-buffered saline (PBS) lasted up to 26 days before fully degrading. Based on microscopic observation, the microspheres were all spherical and hollow inside. The particle size distribution ranged from 19 μm to 22 μm in diameter. The drug release analysis showed that the antibiotic gentamicin loaded on the microspheres was released in a large amount within 2 h of soaking in PBS. It was stabilized until the amount of microspheres integrated was significantly reduced after soaking for 16 days and then released again to form a two-stage drug release curve. In vitro experiments showed that DAP-modified microspheres at concentrations less than 5 wt.% had no cytotoxicity. Antibiotic-impregnated and DAP-modified microspheres had good antibacterial effects against Staphylococcus aureus and Escherichia coli, but these drug-impregnated groups hinder the biocompatibility of hydrogel microspheres. The developed drug carrier can be combined with other biomaterial matrices to form a composite for delivering drugs directly to the affected area in the future to achieve local therapeutic effects and improve the bioavailability of drugs.

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Section: Resultsmentioning

confidence: 99%

In Vitro Characterizations of Post-Crosslinked Gelatin-Based Microspheres Modified by Phosphatidylcholine or Diammonium Phosphate as Antibiotic Delivery Vehicles

Chang

Chen

et al. 2023

Polymers

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“…" Drug encapsulation 95 % ranitidine hydrochloride in simulated gastric fluid 73 % BSA release in simulated intestinal fluid gastro retentive drug delivery system [114] Alginate in polycaprolactone chitosan Capsaicin Nanoparticles in nanofibres "Capsaicin release from 120 h to > 500 h # MCF-7 cells proliferation Non toxic to human dermal fibroblasts " anti cancer activity [115] Floatable high amylose rice starch Glycyrrhizic acid Floatable hybrid gels " water holding capacity " thermal stability " gastro retentive potential [116] Soyabean meal resistant starch NA Nanoscale enteric coating…”

Section: Microspheresmentioning

confidence: 99%

Diversity of Rationally Modified Polysaccharides for Pharmaceutical Applications

et al. 2023

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The pressing need for the development of diversified and non‐toxic biomaterials in recent decades has led to the emergence of novel and valuable structural modifications in polysaccharides to broaden their spectrum of applications. Polysaccharides are macromolecules with multifaceted diverse structures and exhibit wide range of pharmacological and biological activities. Naturally occurring polysaccharides such as starch, chitosan, alginate, acetalated dextran and pectin could potentially negate major concerns associated with the selection of suitable polysaccharides without compromising their unique bioactive nature. Chemical modification of polysaccharides offers distinctive benefits such as improved biocompatibility, stability, solubility, and functionality making them more valuable for a variety of biomedical applications such as drug delivery, gene delivery, cell culture technology and tissue engineering. The present review is a compendium of relevant chemically modified polysaccharides and discusses their role in diverse fields of pharmacy and medicine.

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“…To make drug release controllable, “intelligent” nanoparticles provide new possibilities for cancer treatment, − but it remains difficult to build delivery systems that are responsive to the body’s shifting metabolic conditions. Designing sensitive nanosystems for drug delivery in cancer therapy most commonly involves a pH-responsive system. , Pullulan oxide (oxPL) is an excellent pH-responsive gatekeeper because it is an inexpensive and nontoxic material that can be easily produced, remains stable in neutral environments, and disintegrates easily in acidic conditions. , A synergistic treatment approach combining photothermal therapy with drug therapy has been pursued to enhance the therapeutic efficacy.…”

Section: Introductionmentioning

confidence: 99%

Manganese-Doped Mesoporous Magnetic Nanocarriers for Cancer Treatment

Zhou,

He,

Dong

et al. 2024

ACS Appl. Nano Mater.

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To achieve maximum curative effects and minimize side effects in trimodal synergistic cooperative tumor therapies, we propose a strategy of photothermal (PTT)-chemodynamic (CDT)coordinated drug chemotherapy (DT) trimodal synergistic therapy. We designed a multifunctional manganese-doped mesoporous magnetic nanodrug carrier (NH 2 -MMNPs), which was equipped with pullulan oxide to form Schiff base bonds upon loading doxorubicin (DOX), thus creating an oMMNPs/DOX nanoplatform. This nanoplatform exhibits excellent controlled drug release, satisfactory photothermal conversion efficiency under NIR (808 nm) irradiation, good biodegradability, and targeted drug delivery capabilities. It also produces Fenton-like Mn 2+ in response to the highly expressed glutathione (GSH) in the tumor microenvironment, thereby generating chemodynamic therapy. The oMMNPs/DOX demonstrated remarkable killing efficacy in HeLa and MCF-7 cancer cell cultures and reached 84.1% tumor suppression in vivo. The in vitro and in vivo results confirm that this theranostic nanoplatform exhibits excellent biocompatibility and anticancer effects. Therefore, oMMNPs/DOX have potential utility as a magnetically targeted and pH/GSH/NIR triple-triggered drug carrier for synergistic PTT/CDT/DT therapy.

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Gelatin/alginate-based microspheres with sphere-in-capsule structure for spatiotemporal manipulative drug release in gastrointestinal tract

Cited by 14 publications

References 52 publications

In Vitro Characterizations of Post-Crosslinked Gelatin-Based Microspheres Modified by Phosphatidylcholine or Diammonium Phosphate as Antibiotic Delivery Vehicles

In Vitro Characterizations of Post-Crosslinked Gelatin-Based Microspheres Modified by Phosphatidylcholine or Diammonium Phosphate as Antibiotic Delivery Vehicles

Diversity of Rationally Modified Polysaccharides for Pharmaceutical Applications

Manganese-Doped Mesoporous Magnetic Nanocarriers for Cancer Treatment

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