Gelam (Melaleucaspp.) Honey-Based Hydrogel as Burn Wound Dressing

Abstract

A novel cross-linked honey hydrogel dressing was developed by incorporating Malaysian honey into hydrogel dressing formulation, cross-linked and sterilized using electron beam irradiation (25 kGy). In this study, the physical properties of the prepared honey hydrogel and its wound healing efficacy on deep partial thickness burn wounds in rats were assessed. Skin samples were taken at 7, 14, 21, and 28 days after burn for histopathological and molecular evaluations. Application of honey hydrogel dressings significantly enhanced (P < 0.05) wound closure and accelerated the rate of re-epithelialization as compared to control hydrogel and OpSite film dressing. A significant decrease in inflammatory response was observed in honey hydrogel treated wounds as early as 7 days after burn (P < 0.05). Semiquantitative analysis using RT-PCR revealed that treatment with honey hydrogel significantly (P < 0.05) suppressed the expression of proinflammatory cytokines (IL-1α, IL-1β, and IL-6). The present study substantiates the potential efficacy of honey hydrogel dressings in accelerating burn wound healing.

The Effect of Mesenchymal Stem Cells and Chitosan Gel on Full Thickness Skin Wound Healing in Albino Rats: Histological, Immunohistochemical and Fluorescent Study

“…Wound contraction was calculated at the 3 rd , 5 th , 10 th and 15 th days after wound induction. The percentage of wound healing was calculated as performed by [ 8 , 40 ]: Progressive decrease in wound area was measured periodically by tracing the wound margin on a tracing paper. The tracing was then placed onto 1 mm² graph sheet paper and the numbers of squares were counted.…”

Evidence for Clinical Use of Honey in Wound Healing as an Anti-bacterial, Anti-inflammatory Anti-oxidant and Anti-viral Agent: A Review

“…Honey has been used in folk medicine since ancient times and has more recently been rediscovered by medical researchers for its use in dressing acute and chronic wounds. Traditionally, honey has been used to treat burns, infected and non-healing wounds and ulcers, boils, pilonidal sinus, venous and diabetic foot ulcers (1-6). Recent studies confirm the efficacy of honey in treating venous ulcers (7).…”

Gelam Honey: A Review of Its Antioxidant, Anti-inflammatory, Anticancer and Wound Healing Aspects

“…Based on the histopathological evidence, it showed that honey hydrogel significantly attenuated inflammatory response (p < 0.05) on seventh day of treatment and modulated the proinflammatory cytokines involve in wound healing at molecular level. This study has clearly demonstrated the potential effectiveness of honey hydrogel dressing in accelerating the burn wound healing through the various effects on cellular elements and cytokines involved (Mohd Zohdi et al 2012). …”

“…In addition, a group a researchers worked on the wound healing properties of GH and developed the idea of honey hydrogel dressing for the management of wound healing (Mohd Zohdi et al 2012). It was found out that application of honey hydrogel dressing significantly increased (p < 0.05) wound closure rate and the rate of re-pithelialization compared to control hydrogel and OpSite film dressing.…”