Gelam and Nenas Honeys Inhibit Proliferation of HT 29 Colon Cancer Cells by Inducing DNA Damage and Apoptosis while Suppressing Inflammation

Gelam Honey and Ginger Potentiate the Anti Cancer Effect of 5-FU against HCT 116 Colorectal Cancer Cells

“…There might be differences in the anti-cancer property attributed to differences in the composition of biochemical constituents between different types of honeys (Gheldof et al, 2002;Khalil et al, 2011;Chua et al, 2013). The work documented here is an extension to our previous work in colon adenocarcinoma cell line HT 29 where, we found that Gelam honey exhibited higher chemopreventative effects on HT 29 colon cancer cell line than Nenas honey by inducing apopotosis and suppressing inflammation possibly through its antioxidant property (Wen et al, 2012). These two types of Malaysian honeys have been reported earlier having their antioxidant activities significantly correlated to the content of the phenolic compounds (Hussein et al, 2011).…”

“…Malaysian local honey especially Tualang honey has been found to induce anti-proliferative effects on cervical and breast cancer cell lines (Mohamed et al, 2010) as well as anti-bacterial activity against Acinetobacter baumanni (Fauzi et al, 2011). Likewise, another local honey, Gelam honey has been shown to inhibit the growth of colon cancer cell line namely HT 29 (Wen et al, 2012).…”

Dietary Non-nutritive Factors in Targeting of Regulatory Molecules in Colorectal Cancer: An Update

“…Luteolin, a bioflavonoid induce apoptosis via modulating the expressions of Bcl-2, Bax and caspase-3 in vivo and in vitro Pandurangan and Ganapsam, 2013). Wen et al (2012) reported that gelam and nenas honeys inhibit proliferation of HT-29 colon cancer cells by inducing DNA damage and apoptosis while suppressing inflammation. A ginseng metabolite induces autophagy and apoptosis via generation of reactive oxygen species and activation of JNK in human colon cancer cells .…”

Gelam Honey: A Review of Its Antioxidant, Anti-inflammatory, Anticancer and Wound Healing Aspects

“…It also showed significantly decreased production of prostaglandin E2 (PGE2) levels compared to H202 induced cells without treatment. Thus, the findings suggested that GH is capable to suppress the growth of HT29 colon cancer cells by inducing apoptosis and impeding inflammation (Wen et al 2012).…”

“…Honey is known as natural sweet substance made from honey bees from floral nectar. Honey is commonly used to treat many ailments (Wen et al 2012). Since ancient times, various types of honey and their derivatives are being used to treat several diseases such as cancer, infections, delayed wound healing, etc .…”