Gel Phantom Models for Radiofrequency and Microwave Ablation of the Liver

Chen, Willa; Wang, Qi; Kim, Charles Y.

doi:10.1055/s-0040-1716737

Cited by 3 publications

(1 citation statement)

References 16 publications

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“…Driven by the increasing utilization of RFA and MWA as the prevalent non‐invasive modalities for the management of hepatocellular carcinoma (HCC), gel phantom models intended for RFA and MWA of the liver were quite widely described in the literature, 22 but with only few of them involving thermal heating of a tumor model. In a relevant study, 23 authors constructed a 5% agar cylindrical phantom featuring a cylindrical hole of 2 cm in diameter, which was filled with an agar solution of smaller agar concentration of 0.25% to represent a tumor.…”

Section: Introductionmentioning

confidence: 99%

Tumor phantom model for MRI‐guided focused ultrasound ablation studies

Antoniou,

Evripidou,

Georgiou

et al. 2023

Medical Physics

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BackgroundThe persistent development of focused ultrasound (FUS) thermal therapy in the context of oncology creates the need for tissue‐mimicking tumor phantom models for early‐stage experimentation and evaluation of relevant systems and protocols.PurposeThis study presents the development and evaluation of a tumor‐bearing tissue phantom model for testing magnetic resonance imaging (MRI)‐guided FUS (MRgFUS) ablation protocols and equipment based on MR thermometry.MethodsNormal tissue was mimicked by a pure agar gel, while the tumor simulator was differentiated from the surrounding material by including silicon dioxide. The phantom was characterized in terms of acoustic, thermal, and MRI properties. US, MRI, and computed tomography (CT) images of the phantom were acquired to assess the contrast between the two compartments. The phantom's response to thermal heating was investigated by performing high power sonications with a 2.4 MHz single element spherically focused ultrasonic transducer in a 3T MRI scanner.ResultsThe estimated phantom properties fall within the range of literature‐reported values of soft tissues. The inclusion of silicon dioxide in the tumor material offered excellent tumor visualization in US, MRI, and CT. MR thermometry revealed temperature elevations in the phantom to ablation levels and clear evidence of larger heat accumulation within the tumor owing to the inclusion of silicon dioxide.ConclusionOverall, the study findings suggest that the proposed tumor phantom model constitutes a simple and inexpensive tool for preclinical MRgFUS ablation studies, and potentially other image‐guided thermal ablation applications upon minimal modifications.

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Section: Introductionmentioning

confidence: 99%

Tumor phantom model for MRI‐guided focused ultrasound ablation studies

Antoniou,

Evripidou,

Georgiou

et al. 2023

Medical Physics

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Tissue-Mimicking Phantoms for Photothermal Performance Evaluations

Khurana,

Soni

2024

Materials Horizons: From Nature to Nanomaterials

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Thermochromic phantoms and paint to characterize and model image-guided thermal ablation and ablation devices: a review

Negussie,

Morhard,

Rivera

et al. 2024

Functional Composite Mater

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Heat-based local ablation techniques are effective treatments for specific oligometastatic and localized cancers and are being studied for their potential to induce immunogenic cell death and augment systemic immune responses to immunotherapies. The diverse technologies associated with thermal therapy have an unmet need for method development to enable device-specific experimentation, optimization, calibration and refinement of the parameter space to optimize therapeutic intent while minimizing side effects or risk to the patient. Quality assurance, training, or comparing thermal dose among different modalities or techniques using animal models is time and resource intensive. Therefore, the application and use of tissue mimicking thermosensitive, thermochromic liquid crystal and thermochromic paint phantom models may reduce costs and hurdles associated with animal use. Further, their homogenous composition may enable more precise assessment of ablative techniques. This review utilized SciFinder, Web of Science, PubMed and EMBASE to systematically evaluate the literature describing the background and applications of thermochromic liquid crystal, thermochromic paint and tissue-mimicking thermochromic phantoms used to characterize the thermal effects of ablation devices with a focus on facilitating their use across the medical device development life cycle. Graphical Abstract

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Gel Phantom Models for Radiofrequency and Microwave Ablation of the Liver

Cited by 3 publications

References 16 publications

Tumor phantom model for MRI‐guided focused ultrasound ablation studies

Tumor phantom model for MRI‐guided focused ultrasound ablation studies

Tissue-Mimicking Phantoms for Photothermal Performance Evaluations

Thermochromic phantoms and paint to characterize and model image-guided thermal ablation and ablation devices: a review

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