Gel nasal y hendidura olfatoria

González‐Botas, Jesús Herranz; Seara, Anselmo Padín

doi:10.1016/j.otorri.2012.05.001

Cited by 6 publications

(3 citation statements)

References 18 publications

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“…The results of this study corroborate the previous finding that nasal spray droplets predominantly deposit in the anterior nose, i.e., the vestibule and nasal valve. Using a radial-hole inhaler, Herranz González-Botas et al [ 10 ] observed no dye deposition at the olfactory cleft and middle turbinate but abundantly in the nasal vestibule, nasal septum, and inferior turbinate. Similar observations have been reported by Guo et al [ 32 ], who tested different visualization methods (isotopes, dyes, endoscopy) in nasal hollow casts, and Xi et al [ 51 ] who tested four types of nasal sprays in the sectional nasal casts, where only a small fraction of applied nasal spray penetrated beyond the nasal valve.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have demonstrated that less than 1% of applied aerosol medications reached the olfactory region [ 9 ]. Using a standard radial-hole inhaler with 140 mL per actuation, González-Botas et al [ 10 ] observed dominant deposition in the nasal valve and inferior meatus, but nearly no deposition at the olfactory cleft. This extremely low bioavailability has prevented nose-to-brain delivery in clinical applications and acts as the bottleneck for the development of new neurological medications [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

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Liquid Film Translocation Significantly Enhances Nasal Spray Delivery to Olfactory Region: A Numerical Simulation Study

April

Sami

2021

Pharmaceutics

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Previous in vivo and ex vivo studies have tested nasal sprays with varying head positions to enhance the olfactory delivery; however, such studies often suffered from a lack of quantitative dosimetry in the target region, which relied on the observer’s subjective perception of color changes in the endoscopy images. The objective of this study is to test the feasibility of gravitationally driven droplet translocation numerically to enhance the nasal spray dosages in the olfactory region and quantify the intranasal dose distribution in the regions of interest. A computational nasal spray testing platform was developed that included a nasal spray releasing model, an airflow-droplet transport model, and an Eulerian wall film formation/translocation model. The effects of both device-related and administration-related variables on the initial olfactory deposition were studied, including droplet size, velocity, plume angle, spray release position, and orientation. The liquid film formation and translocation after nasal spray applications were simulated for both a standard and a newly proposed delivery system. Results show that the initial droplet deposition in the olfactory region is highly sensitive to the spray plume angle. For the given nasal cavity with a vertex-to-floor head position, a plume angle of 10° with a device orientation of 45° to the nostril delivered the optimal dose to the olfactory region. Liquid wall film translocation enhanced the olfactory dosage by ninefold, compared to the initial olfactory dose, for both the baseline and optimized delivery systems. The optimized delivery system delivered 6.2% of applied sprays to the olfactory region and significantly reduced drug losses in the vestibule. Rheological properties of spray formulations can be explored to harness further the benefits of liquid film translocation in targeted intranasal deliveries.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Liquid Film Translocation Significantly Enhances Nasal Spray Delivery to Olfactory Region: A Numerical Simulation Study

April

Sami

2021

Pharmaceutics

View full text Add to dashboard Cite

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“…Indeed, it is unclear how much of the zinc spray actually reaches the olfactory cleft. Notable in this context are the results of experiments by Herranz Gonzalez-Botas and Padin Seara, who examined the efficacy of the nasal gel form of application and ascertained that pigmented nasal gel is not detectable in the olfactory cleft following self-application by 16 test subjects [101]. …”

Section: Industrial Chemicals With a Potential Impact Upon Olfactionmentioning

confidence: 99%

Olfactory dysfunction revisited: a reappraisal of work-related olfactory dysfunction caused by chemicals

Werner

Nies

2018

J Occup Med Toxicol

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Occupational exposure to numerous individual chemicals has been associated with olfactory dysfunction, mainly in individual case descriptions. Comprehensive epidemiological investigations into the olfactotoxic effect of working substances show that the human sense of smell may be impaired by exposure to metal compounds involving cadmium, chromium and nickel, and to formaldehyde. This conclusion is supported by the results of animal experiments. The level of evidence for a relationship between olfactory dysfunction and workplace exposure to other substances is relatively weak.

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International consensus statement on allergy and rhinology: Olfaction

Patel

Holbrook

Turner

et al. 2022

Int Forum Allergy Rhinol

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Background:The literature regarding clinical olfaction, olfactory loss, and olfactory dysfunction has expanded rapidly over the past two decades, with an exponential rise in the past year. There is substantial variability in the quality of this literature and a need to consolidate and critically review the evidence. It is with that aim that we have gathered experts from around the world to produce this International Consensus on Allergy and Rhinology: Olfaction (ICAR:O). Methods: Using previously described methodology, specific topics were developed relating to olfaction. Each topic was assigned a literature review, evidence-based review, or evidence-based review with recommendations format as dictated by available evidence and scope within the ICAR:O document. Following iterative reviews of each topic, the ICAR:O document was integrated and reviewed by all authors for final consensus. Results:The ICAR:O document reviews nearly 100 separate topics within the realm of olfaction, including diagnosis, epidemiology, disease burden, diagnosis, testing, etiology, treatment, and associated pathologies. Conclusion:This critical review of the existing clinical olfaction literature provides much needed insight and clarity into the evaluation, diagnosis, and treatment of patients with olfactory dysfunction, while also clearly delineating gaps in our knowledge and evidence base that we should investigate further.

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Gel nasal y hendidura olfatoria

Cited by 6 publications

References 18 publications

Liquid Film Translocation Significantly Enhances Nasal Spray Delivery to Olfactory Region: A Numerical Simulation Study

Liquid Film Translocation Significantly Enhances Nasal Spray Delivery to Olfactory Region: A Numerical Simulation Study

Olfactory dysfunction revisited: a reappraisal of work-related olfactory dysfunction caused by chemicals

International consensus statement on allergy and rhinology: Olfaction

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