Gel Dosimetry Analysis of Gold Nanoparticle Application in Kilovoltage Radiation Therapy

Marques, T; Schwarcke, M; Garrido, C; Zucolot, V; Baffa, Oswaldo; Nicolucci, Patrícia

doi:10.1088/1742-6596/250/1/012084

Cited by 22 publications

(12 citation statements)

References 8 publications

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“…Recently, using a polymer gel dosimeter impregnated with GNP has been suggested as a reliable method to perform the dosimetric investigation of GNP application in radiotherapy. Previous studies considering beam energy and GNP concentration utilizing various polymer gels have been accomplished successfully [13-14]. Therefore, the dosimetric study of GNP using a tissue equivalent polymer gel would be a remarkable method to verify the current biological and simulation studies and also help to justify the applicability of GNP in clinical environments.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Gold Nanoparticle Size Effect on Dose Enhancement Factor in Megavoltage Beam Radiotherapy Using MAGICA Polymer Gel Dosimeter

et al. 2019

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Background: Gold nanoparticles (GNPs) are among the most promising radiosensitive materials in radiotherapy. Studying the effective sensitizing factors such as nanoparticle size, concentration, surface features, radiation energy and cell type can help to optimize the effect and possible clinical application of GNPs in radiation therapy. In this study, the radiation sensitive polymer gel was used to investigate the dosimetric effect of GNP size in megavoltage (MV) photon beam radiotherapy.Material and Methods: GNPs with the size of 30nm, 50nm and 100nm in diameter were used. Transmission electron microscope (TEM) and dynamic light scattering (DLS) were applied to analyze the size of nanoparticles. The MAGICA polymer gel was synthesized and impregnated with different sizes of GNPs. The samples were irradiated with 6MV photon beam and 24 hours after irradiation, they were read using a Magnetic Resonance Imaging (MRI) scanner. Macroscopic Dose Enhancement Factor (DEF) was measured to compare the effect of GNP size. The MAGICA response of the 6MV x-ray beam was verified comparing Percentage Depth Dose (PDD) curve extracted from polymer gel dosimetry and Treatment Planning System (TPS).Results: MAGICA polymer gel dose response curve was linear in the range of 0 to 10 Gy. DEFs by adding 30nm, 50nm and 100nm GNPs were 1.1, 1.17 and 1.12, respectively. PDD curves of polymer gel dosimeter and treatment planning system were in good agreement.Conclusion: The results indicated a substantial increase in DEF uses a MV photon beam in combination with GNPs of different sizes and it was inconsistent with previous radiobiological studies. The maximum DEF was achieved for 50nm GNPs in comparison with 30nm and 100nm leading to the assumption of self-absorption effect by larger diameters. According to the outcomes of this work, MAGICA polymer gel can be recommended as a reliable dosimeter to investigate the dosimetric effect of GNP size and also a useful method to validate the current radiobiological and simulation studies.

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Section: Introductionmentioning

confidence: 99%

Evaluation of Gold Nanoparticle Size Effect on Dose Enhancement Factor in Megavoltage Beam Radiotherapy Using MAGICA Polymer Gel Dosimeter

et al. 2019

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“…Radio-sensitization observed by several authors indicates that gold nanoparticles (AuNP) are the best candidates for use in radionanotherapy [6–11]. From the dosimetric point of view, the use of Au nanoparticles in radiotherapy was motivated by the fact that probability of photoelectric effect increases due to the presence of high Z (Au = 79) material inside the polymer gels, which in turn increases the absorbed dose [12]. Ag and Au nanoparticles have attracted immense attention among researchers and practitioners because of their potential application in different fields, such as chemical and biochemical sensing, biological imaging, medical diagnostics and therapeutic treatment.…”

Section: Introductionmentioning

confidence: 99%

Enhancement of Dose Response and Nuclear Magnetic Resonance Image of PAGAT Polymer Gel Dosimeter by Adding Silver Nanoparticles

et al. 2017

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In the present study, the normoxic polyacrylamide gelatin and tetrakis hydroxy methyl phosphoniun chloride (PAGAT) polymer gel dosimeters were synthesized with and without the presence of silver (Ag) nanoparticles. The amount of Ag nanoparticles varied from 1 to 3 ml with concentration 3.14 g/l, thus forming two types of PAGAT polymer gel dosimeters before irradiating them with 6 to 25 Gy produced by 1.25-MeV 60Co gamma rays. In this range, the predominant gamma ray interaction with matter is by Compton scattering effect, as the photoelectric absorption effect diminishes. MRI was employed when evaluating the polymerization of the dosimeters and the gray scale of the MRI film was determined via an optical densitometer. Subsequent analyses of optical densities revealed that the extent of polymerization increased with the increase in the absorbed dose, while the increase of penetration depth within the dosimeters has a reverse effect. Moreover, a significant increase in the optical density-dose response (11.82%) was noted for dosimeters containing 2 ml Ag nanoparticles.

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“…Marques et al analyzed the dose enhancement of gold nanoparticle on MAGIC-f polymer gel dosimeter by using 250KV X-rays. He found that DEF was 106%, 90% and 77% over the concentration of 0.10mM, 0.05mM and 0.02mM [18]. Also, many researchers have studied the dose enhancement effect of the gold nanoparticle using polymer gel dosimeter [19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Radiation dose enhancement of gold nanoparticle on different polymer gel dosimeters

Samuel

Srinivasan

Poopathi

2017

J. Phys.: Conf. Ser.

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Abstract. In this work, we evaluated the dose enhancement produced by gold nanoparticle on ten different polymer gel dosimeters with a concentration of 7mgAu /g over a wide photon energy range of 15KeV to 20MeV and the results were compared with Soft tissue ICRU-44 produced. Our result showed that maximum DEF was observed at 40KeV, while it was almost negligible at higher energy range. Dose enhancement produced by AuNP on the gel dosimeter medium was varied compared to the reference ICRU-44 tissue, it was ± <1% for PAGAT, NIPAM, nPAG and ± <5% for PABIG, VIPAR, HEAG, BANG1, nMAG & ± <10% for MAGIC, ABAGIC gel dosimeters. Hence, we conclude that choosing the proper gel dosimeter is essential in dose enhancement study.

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Gel Dosimetry Analysis of Gold Nanoparticle Application in Kilovoltage Radiation Therapy

Cited by 22 publications

References 8 publications

Evaluation of Gold Nanoparticle Size Effect on Dose Enhancement Factor in Megavoltage Beam Radiotherapy Using MAGICA Polymer Gel Dosimeter

Evaluation of Gold Nanoparticle Size Effect on Dose Enhancement Factor in Megavoltage Beam Radiotherapy Using MAGICA Polymer Gel Dosimeter

Enhancement of Dose Response and Nuclear Magnetic Resonance Image of PAGAT Polymer Gel Dosimeter by Adding Silver Nanoparticles

Radiation dose enhancement of gold nanoparticle on different polymer gel dosimeters

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