Gel-derived SiO2–CaO–Na2O–P2O5 bioactive powders: Synthesis and in vitro bioactivity

Siqueira, Renato Luiz; Peitl, Oscar; Zanotto, Edgar Dutra

doi:10.1016/j.msec.2011.02.018

Cited by 97 publications

(74 citation statements)

References 26 publications

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“…Sol-gel glasses with a composition close to the 45S5 Bioglass ® were synthesized in the simpler systems SiO 2 -CaO-P 2 O 5 or SiO 2 -CaO, without any Na 2 O, by Hench's group (Li et al 1991;Siqueira et al 2011). A comparison of sol-gel-derived and melt-quench-derived 45S5 Bioglass ® is illustrated in Fig.…”

Section: Bioactive Glassesmentioning

confidence: 99%

Biomaterials Obtained by Gelation

Pierre¹

2016

Handbook of Sol-Gel Science and Technology

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Section: Bioactive Glassesmentioning

confidence: 99%

Biomaterials Obtained by Gelation

Pierre¹

2016

Handbook of Sol-Gel Science and Technology

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“…However, glass utilizations as scaffold material is limited due to its brittleness and lack in mechanical properties. Sintering is known to cause crystallization of glass and turn this amorphous material into glass ceramic phase which may enhanced their mechanical properties due to densification, formation of crystallized phases and grain growth (Siqueira et al 2011;Stábile et al 2015).…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Macroporous Bioactive Glass Ceramic made via Sol-Gel Route and Powder Sintering Method

Adam¹,

Shamsudin²,

Zainuddin³

et al. 2018

JSM

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“…The choice of synthetic precursor greatly influences the properties of bioactive glasses. The variation in precursor may lead to the formation of different crystalline phases under same heat treatment condition [11]. Previous literature has shown the effect of CaO [12] and P 2 O 5 [11] precursors on sol-gel derived bioactive glasses.…”

Section: Introductionmentioning

confidence: 99%

A study of the effect of precursors on physical and biological properties of mesoporous bioactive glass

et al. 2014

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A novel mesoporous bioactive glass (MBG) of composition 64SiO 2 -26CaO-10P 2 O 5 (mol %) was prepared by hydrothermal method using H 3 PO 4 as a precursor for P 2 O 5 . The effect of use of organic triethylphosphate (TEP) and inorganic H 3 PO 4 in MBG synthesis on glass transition temperature (T g ), crystallinity, morphology and bioactivity of MBGs was studied. Phase purity determination and structural analysis were done using powder X-ray diffraction (XRD) and Fourier transform infrared (FTIR) spectroscopy, respectively. XRD revealed that MBG prepared from H 3 PO 4 (MBG-H 3 PO 4 ) when sintered at 700°C was partially glassy/amorphous in nature and contained a mixture of crystalline apatite, wollastonite, calcium phosphate and calcium silicate phases. Calcined MBG prepared from TEP (MBG-TEP) contained only wollastonite and calcium silicate phases. Particle size and surface area determined by BET surface area analysis showed higher surface area (310 m 2 g -1 ) for MBG-H 3 PO 4 as compared to MBG-TEP (86 m 2 g -1 ). It also had a smaller particle size (20 nm) and 70 % higher pore volume (0.88 cm 3 g -1 ) for MBG-H 3 PO 4 as compared to MBG-TEP (60 nm particle size and 0.23 cm 3 g -1 pore volume). Thermal studies showed that use of H 3 PO 4 decreases T g and increased DT (difference between T g and crystallization initiation temperature Tc o ). Low T g and high DT also enhanced bioactivity of MBGs. Bioactivity was determined by immersion in a simulated body fluid for varying time intervals for a maximum period of 14 days. It revealed enhanced bioactivity, as evident by the formation of apatite layer on the surface, for MBG-H 3 PO 4 as compared to MBG-TEP. Scanning electron microscopy and FTIR spectroscopy also supported this observation. Antibacterial studies with Escherichia Coli bacteria, MBG-H 3 PO 4 showed better antibacterial behaviour than MBG-TEP.

show abstract

Gel-derived SiO2–CaO–Na2O–P2O5 bioactive powders: Synthesis and in vitro bioactivity

Cited by 97 publications

References 26 publications

Biomaterials Obtained by Gelation

Biomaterials Obtained by Gelation

Preparation and Characterization of Macroporous Bioactive Glass Ceramic made via Sol-Gel Route and Powder Sintering Method

A study of the effect of precursors on physical and biological properties of mesoporous bioactive glass

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