Gel de Chamomilla Recutita para reação de pele em paciente submetido à quimiorradioterapia: relato de caso

Abstract

RESUMOO presente relato tem o objetivo de descrever o efeito do gel de Chamomilla recutita (C. recutita) em radiodermatite de paciente submetido à quimiorradioterapia -paciente do sexo masculino, com neoplasia de orofaringe, que fez uso do gel na concentração de 8,35% na região irradiada. A partir da 16ª sessão, o paciente apresentou radiodermatite Grau I, segundo escore Radiation Therapy Oncology Group (RTOG), caracterizada por leve eritema da região irradiada. A graduação foi mantida até o fi nal da radioterapia, com evolução dos sinais apresentados para hipercromia e descamação seca. Os benefícios clínicos da C. recutita na prevenção e no tratamento da radiodermatite evidenciam a importância de estudos experimentais, que possam corroborar os resultados descritos, considerando que a intervenção se mostrou uma alternativa de fácil implementação, fornecendo proteção e conforto ao paciente. DESCRITORES:Radiodermatite. Quimiorradioterapia. Chamomilla. Estomaterapia. ABSTRACTThis report aims at describing the eff ect of Chamomilla recutita (C. recutita) gel in radiodermatitis of a patient submitted to chemoradiotherapy -male patient, with oropharyngeal cancer, that used the gel in the 8.35% concentration in the irradiated region. From the 16 th session, the subject presented Grade I radiodermatitis, according to the RTOG score, characterized by mild erythema in the irradiated region. Graduation was maintained until the end of radiotherapy, with an increase of the signals presented for hyperpigmentation and dry desquamation. The clinical benefi ts of C. recutita in the prevention and treatment of radiodermatitis show the importance of experimental studies that may corroborate the described results, considering that the intervention proved to be an alternative of easy implementation, thus providing protection and comfort to the patient.

MASCC clinical practice guidelines for the prevention and management of acute radiation dermatitis: part 1) systematic review

“…Insufficient evidence was reported to support the use of urea, Xonrid, hydroactive colloid gel, and other interventions. 21 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 , 136 , 137 , 138 , 139 , 140 , 141 , 142 , 143 , 144 , 145 , 146 , 147 , 148 , 149 , 150 , 151 , 152 , 153 , 154 , 155 , 156 Growth factors and oral agents 9 (7) 1721 (78; 40-1142) Enzyme mixture (3); Other (6) Head and neck (5); Breast (2); Multiple (1); Cervical (1) ...…”

“…Natural and miscellaneous agents were assessed in 51 studies, of which 39 were RCTs 21 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 , 136 , 137 , 138 , 139 , 140 , 141 , 142 , 143 , 144 , 145 , 146 , 147 , 148 , 149 , 150 , 151 , 152 , 153 , 154 , 155 , 156 ( Appendix C, Table 5 ). The majority of interventions showed minimal or no benefit protecting against ARD in a randomized setting, including honey-based products, 125 , 126 vitamins, 129 , 130 chamomile-based cream, 141 calendula (marigold)-based products, 113 , 116 and products containing glutamine.…”

A Chitosan-Coated Chamomile Microparticles Formulation to Prevent Radiodermatitis in Breast

“…Third, it cannot alter or reduce the radiation action, that is, protecting the tumor from radiation damage. 13 In this context, Chamomilla recutita (L.) Rauschert, a plant with anti-inflammatory properties, [14][15][16][17] which is used in clinical practice as an infusion, has been investigated in the reduction of inflammation induced by radiation, and there is evidence showing its benefits on the intensity of inflammatory RT reactions 18,19 with no tumor protection. Associated with the healing effect and anti-inflammatory properties of chamomile the controlled release system present in the microparticles may decrease the incidence and severity of these injuries.…”