“…From another approach, namely, local stimulation of the hypothalamus, much evidence has accumulated for an hypothalamic representation of the sympathetic (Karplus and Kreidl,28,29,30,31,32;Houssay and Molinelli,24). This, plus the fact that sympathetic representation is apparently not present in the thalamus (Karplus and Kreidl,28,29,30,31,32;Ranson and Magoun,40;Sachs,43), supplements the other evidence in indicating that the central mechanism responsible for the organ-ization of sympathetic activity characteristic of emergency states is located in the hypothalamus. Bard's work (6,7,8), of course, indicates that it is only when these diencephaJic mechanisms are present that the individual segments of the rage response, which are, or can be, controlled by centers lying below the level of the diencephalon, are organized to form the extremely vigorous rage reaction.…”