Gegenüberstellung klinischer, echographischer und histologischer Befunde beim malignen Melanom der Aderhaut*

Guthoff, R.; Domarus, D. von; Schroeder, W.

doi:10.1055/s-2008-1057322

Cited by 8 publications

(8 citation statements)

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“…Eichler et al 7 and Guthoff et al 8 9 described typical patterns of reflectivity of uveal melanomas after brachytherapy with a marked reduction of tumour height and a simultaneous increase in the degree of reflectivity after 4 months. Relapses are characterised by an increase in prominence and a continuously low, or decrease in, reflectivity.…”

Section: Discussionmentioning

confidence: 99%

“…Tumours larger than 5 mm had a half life averaging 18 months (minimum 6 months, maximum 2 years) and complete regression was observed in two cases after 1 year. Guthoff et al 9correlates the speed of regression with the prognosis for survival. Tumours with a rapid rate of regression were found to have a significantly higher risk for metastasis than tumours with a slow rate of regression.…”

Section: Discussionmentioning

confidence: 99%

“…Tumours with a rapid rate of regression were found to have a significantly higher risk for metastasis than tumours with a slow rate of regression. According to Guthoff et al ,8 9 the rate of regression as well as the tumour size should be considered as individual prognostic factors since a rapid radiogenic decrease in volume indicates a poor prognosis for survival.…”

Section: Discussionmentioning

confidence: 99%

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Echographic findings in uveal melanomas treated with the Leksell gamma knife

Müllner¹,

Langmann²,

Pendl³

et al. 1998

British Journal of Ophthalmology

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Background/aims-Between June 1992 and July 1995, 29 uveal melanomas were treated radiosurgically with the Leksell gamma unit at the University of Graz. The aim of this retrospective study was to examine the pattern of regression and the extent and time period of the decrease in tumour size. Methods-The Leksell gamma knife, model B, was used. Patients were divided into three groups according to marginal dose: group 1: eight patients with a marginal dose >50 Gy, group 2: 15 patients with a marginal dose = 50 Gy, and group 3: six patients with a marginal dose = 45 Gy. For the retrospective study two groups were examined: group A, tumours <5 mm and group B, tumours >5 mm. Results-No significant correlation was found between tumour regression and the marginal dose. Tumour shrinkage depends on the pretreatment height. In the group of eight patients with an initial tumour prominence of less than 5 mm, no prominence was found after therapy. In the group of patients with an original tumour prominence of 5 mm and more, only two tumours formed a flat scar while a residual prominence was found in 18 patients. Increase in reflectivity combined with a decrease in size appears to be a good criterion for the eVectiveness of the treatment. In five patients with tumours showing low reflectivity, over a longer period of time metastases were found. An enucleation was performed in two patients because of uncertain tumour regression and in one patient as a result of an increase in tumour size. Conclusion-The pattern of echographic reflectivity and decrease in size is similar to brachytherapy and is one of the most important diagnostic variables for evaluation of tumour regression. An increase in reflectivity as well as a decrease in tumour size in the first 6-8 months can be considered a therapeutic success. (Br J Ophthalmol 1998;82:154-158) Ever since cobalt-125, ruthenium-106 applicators, and teletherapy (proton, helium ions)

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Echographic findings in uveal melanomas treated with the Leksell gamma knife

Müllner¹,

Langmann²,

Pendl³

et al. 1998

British Journal of Ophthalmology

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“…Unser Ziel war es, unsere Ergebnisse mit den vorliegenden Berichten nach Brachytherapie mit Ruthenium-106 zu vergleichen [2-6, 8, 10]. Eichler [3] and Guthoff [4,5] beschreiben das typische Reflexionsverhalten von Aderhautmelanomen nach RuBrachytherapie mit einer deutlichen Tumorhohenreduktion and gleichzeitigen Steigerung des Reflexionsgrades nach 4 Monaten. Rezidive sind durch eine Zunahme der Prominenz mit gleichbleibend, niedriger oder abnehmender Reflexion gekennzeichnet.…”

Section: Diskussionunclassified

“…Die durchschnittliche Grol3enzunahme betrug 0 ; 4 mm (± 0,3 mm) and war abhangig von der Tumorausgangshohe. Tumore fiber 8 mm zeigten [3] and Guthoff [4,5] uberein, die eine niedrige Reflektivitat fur ein ungunstiges Zeichen halten.…”

Section: Diskussionunclassified