Gedye Dementia Scale for Down Syndrome

Jozsvai, Emöke; Hewitt, Spencer; Gedye, A.

doi:10.1007/978-3-319-61720-6_4

Cited by 5 publications

(6 citation statements)

References 47 publications

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“…Levels of intellectual disability ranged from mild (1%), moderate (23%), severe (5%) to profound (30%) in the Down syndrome group with comparable distribution in the control group. The DSDS showed good psychometric properties with a sensitivity of .85 and a specificity of .89 when comparing clinician's diagnosis of dementia with rating from the DSDS (Jozsvai et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Assessment of dementia in a clinical sample of persons with intellectual disability

Rösner

Berger

Tarasova

et al. 2021

Research Intellect Disabil

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Background Assessment of age‐associated disorders has become increasingly important. Methods In a clinical setting, people with intellectual disability with and without dementia were assessed retrospectively using the Neuropsychological Test Battery (NTB) and the Dementia Questionnaire for People with Learning Disabilities (DLD) at two different times to analyse neuropsychological changes and diagnostic validity. One group (n = 44) was assessed with both instruments, while the DLD was applied in 71 patients. Results In the NTB (n = 44), only patients with dementia (n = 26) showed a decline in the NTB total score and three subscales. Receiver operating characteristic analysis revealed a diagnostic sensitivity of .67, a specificity of .81, and an area under the curve (AUC) of .767. In the DLD group (n = 71), only those with dementia displayed a decrease in the cognitive and social scale; diagnostic sensitivity and specificity values were low (.61/.63) and the AUC was .704. Conclusions Neuropsychological assessment was sensitive to detect cognitive changes over time. Sensitivity values of both instruments suggest a reassessment at a later time point.

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Section: Introductionmentioning

confidence: 99%

Assessment of dementia in a clinical sample of persons with intellectual disability

Rösner

Berger

Tarasova

et al. 2021

Research Intellect Disabil

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“…The vast majority of the sample was rated as having no dementia on the DSDS, but most had non-zero CDR-QDS and CDR-IDS scores; the 2 individuals flagged for reassessment or rated as early dementia on the DSDS had higher CDR-QDS scores, as well as CDR-IDS adjusted global scores consistent with moderate and severe dementia. The DSDS was developed and validated in a community sample of individuals the majority of whom had severe to profound intellectual disability which could result in low sensitivity of the DSDS in detecting dementia in higher functioning individuals [16, 17]. We note that in another instrument, the DSQIID, has been adapted by the National Task Group (NTG) on Intellectual Disabilities and Dementia Practices as an Early Detection Screen for Dementia (NTG-EDSD [41]), for wide use in dementia screening.…”

Section: Discussionmentioning

confidence: 99%

“…It contains a total of 60 items scored as present, absent, typical of the individual, or not applicable; 20 items assess early-stage dementia, 20 items assess middle stage dementia, 15 items assess late-stage dementia, and 5 items assess very late-stage dementia [15]. The DSDS was developed and standardized in a sample of adults the majority of whom had severe to profound intellectual disability; hence, the most common criticism is that it may not be sensitive enough to detect dementia in higher functioning individuals [16, 17]. A counterargument to this criticism is that informants may not be able to detect early dementia-related changes in such individuals [17].…”

Section: Introductionmentioning

confidence: 99%

Adaptation of the Clinical Dementia Rating Scale for adults with Down syndrome

Lessov‐Schlaggar

Rosario

Morris

et al. 2019

J Neurodevelop Disord

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BackgroundAdults with Down syndrome (DS) are at increased risk for Alzheimer disease dementia, and there is a pressing need for the development of assessment instruments that differentiate chronic cognitive impairment, acute neuropsychiatric symptomatology, and dementia in this population of patients.MethodsWe adapted a widely used instrument, the Clinical Dementia Rating (CDR) Scale, which is a component of the Uniform Data Set used by all federally funded Alzheimer Disease Centers for use in adults with DS, and tested the instrument among 34 DS patients recruited from the community. The participants were assessed using two versions of the modified CDR—a caregiver questionnaire and an in-person interview involving both the caregiver and the DS adult. Assessment also included the Dementia Scale for Down Syndrome (DSDS) and the Raven’s Progressive Matrices to estimate IQ.ResultsBoth modified questionnaire and interview instruments captured a range of cognitive impairments, a majority of which were found to be chronic when accounting for premorbid function. Two individuals in the sample were strongly suspected to have early dementia, both of whom had elevated scores on the modified CDR instruments. Among individuals rated as having no dementia based on the DSDS, about half showed subthreshold impairments on the modified CDR instruments; there was substantial agreement between caregiver questionnaire screening and in-person interview of caregivers and DS adults.ConclusionsThe modified questionnaire and interview instruments capture a range of impairment in DS adults, including subthreshold symptomatology, and the instruments provide complementary information relevant to the ascertainment of dementia in DS. Decline was seen across all cognitive domains and was generally positively related to age and negatively related to IQ. Most importantly, adjusting instrument scores for chronic, premorbid impairment drastically shifted the distribution toward lower (no impairment) scores.

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“…A total of 83 adults with confirmed DS were recruited as previously described [24] . Participants were assessed for dementia using the Dementia Scale for Down Syndrome [25] . Three individuals who received a cognitive cutoff score > 3 (indicating dementia) were removed from this analysis.…”

Section: Methodsmentioning

confidence: 99%

The use of Centiloids for applying [¹¹C]PiB classification cutoffs across region‐of‐interest delineation methods

Tudorascu

Minhas

Lao

et al. 2018

Alz & Dem Diag Ass & Dis Mo

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Introduction Centiloid standardization was developed to establish a quantitative outcome measure of amyloid burden that could accommodate the integration of different amyloid positron emission tomography radiotracers or different methods of quantifying the same tracer. The goal of this study was to examine the use of Centiloids for establishing amyloid classification cutoffs for differing region-of-interest (ROI) delineation schemes. Methods Using ROIs from hand-drawn delineation in native space as the gold standard, we compared standard uptake value ratios obtained from the 6 hand-drawn ROIs that determine amyloid-positivity classification with standard uptake value ratio obtained from 3 different automated techniques (FreeSurfer, Statistical Parametric Mapping, and superimposed hand-drawn ROIs in Pittsburgh Compound B template space). We tested between-methods reliability using repeated measures models and intraclass correlation coefficients. Results We found high reliability between the hand-drawn standard method and other methods for almost all the regions considered. However, small differences in standard uptake value ratio were found to lead to unreliable classifications when the hand-drawn native space-derived cutoffs were used across other ROI delineation methods. Discussion The use of Centiloid standardization greatly improved the agreement of Pittsburgh Compound B classification across methods and may serve as an alternative method for applying cutoffs across methodologically different outcomes.

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Gedye Dementia Scale for Down Syndrome

Cited by 5 publications

References 47 publications

Assessment of dementia in a clinical sample of persons with intellectual disability

Assessment of dementia in a clinical sample of persons with intellectual disability

Adaptation of the Clinical Dementia Rating Scale for adults with Down syndrome

The use of Centiloids for applying [¹¹C]PiB classification cutoffs across region‐of‐interest delineation methods

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Gedye Dementia Scale for Down Syndrome

Cited by 5 publications

References 47 publications

Assessment of dementia in a clinical sample of persons with intellectual disability

Assessment of dementia in a clinical sample of persons with intellectual disability

Adaptation of the Clinical Dementia Rating Scale for adults with Down syndrome

The use of Centiloids for applying [11C]PiB classification cutoffs across region‐of‐interest delineation methods

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The use of Centiloids for applying [¹¹C]PiB classification cutoffs across region‐of‐interest delineation methods