GDPD5, a choline-generating enzyme and its novel role in tumor cell migration

Marchan, Rosemarie

doi:10.1007/s00204-016-1847-z

Cited by 6 publications

(3 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Serum responsive element (SRE), a nuclear regulator of the MAP kinase cascade and transcription factor, is inhibited by GDPD5 [26] . As a positive regulator of oncogenesis, GDPD5 is also related with breast cancer [27] . It has been identi ed that there are three isoforms of MGAT enzyme to date: MGAT1, MGAT2, and MGAT3.…”

Section: Discussionmentioning

confidence: 99%

Expression of Lipid Metabolism Genes Is Correlated With Immune Microenvironment and Predicts Prognosis in Endometrial Carcinoma

Chen,

Liu

et al. 2024

Preprint

View full text Add to dashboard Cite

Objective Endometrial carcinoma (EC) is one of the most prevalent types of gynecologic cancer. The purpose of this work was to identify the metabolic-related biological characteristics of endometrial cancer and to investigate the immune-related molecular pathways of carcinogenesis in endometrial cancer. Methods Data from The Cancer Genome Atlas (TCGA) were utilized to identify lipid metabolism-related genes (LMRGs) with significant correlations to the prognosis of EC patients. Enrichment of functional pathways within the LMRGs was studied. LASSO and Cox regression analysis were conducted to identify LMRGs that were significantly associated with the prognosis of EC patients. We created a prognostic signature and proved its effectiveness in both training and validation groups. In addition, we constructed a complete nomogram consisting of risk models and clinical variables to estimate the survival probability of EC patients. Results ACOT11, CYP1A2, GDPD5, MOGAT3, OLAH, PIASS4, PIP5K1C, PLPP2, and SRD5A1 were discovered to be strongly associated with the clinical outcomes of EC patients. On the basis of these nine LMRGs, we generated and validated our predictive signature using the training and validation cohorts. In addition to being independent of other clinical factors, the nine-LMRG signature distinguished between patients at high- and low-risk for EC and predict EC patient's probability of survival. Statistically, the nomogram exhibited a high correlation between survival forecasts and observations. In the high-risk group, immune/stromal scores were lower and there was a higher density of several kinds of immune cells. Conclusions The LMRG's prognostic model and comprehensive nomogram could guide therapeutic choices in clinical practice, and explore the underlying mechanisms involved in EC progression.

show abstract

Section: Discussionmentioning

confidence: 99%

Expression of Lipid Metabolism Genes Is Correlated With Immune Microenvironment and Predicts Prognosis in Endometrial Carcinoma

Chen,

Liu

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…GDPD, as a family of enzymes that can hydrolyze glycerophosphodiesters into sn-glycerol-3-phosphate and the corresponding alcohols, is pivotal in a variety of physiological processes in the prokaryotes and eukaryotes [ 52 ]. Previous discoveries have also provided a great deal of evidence concerning the involvement of GDPD5, a member of the GDPD family, in the progression of tumors and the DDP resistance in tumors by acting as the target gene of miRNAs, as well as the discussion on the interaction between GDPD5 and miR-874-3p in colorectal cancer, where GDPD5 was identified as the target gene of miR-874-3p and overexpressed GDPD5 eliminated the effects of miR-874-3p triggered on the tumor inhibition and ferroptosis of colorectal cancer cells [ 32 , 53 , 54 ]. Nevertheless, the role of GDPD5 in the mechanism via which miR-874-3p exerted its effects on GC needed to be additionally elucidated.…”

Section: Discussionmentioning

confidence: 99%

MiR-874-3p represses the migration and invasion yet promotes the apoptosis and cisplatin sensitivity via being sponged by long intergenic non-coding RNA 00922 (LINC00922) and targeting Glycerophosphodiester Phosphodiesterase Domain Containing 5 (GDPD5) in gastric cancer cells

et al. 2022

View full text Add to dashboard Cite

Our study mainly reports the specific mechanisms of microRNA (miR)-874-3p on drug resistance in gastric cancer (GC). Clinical specimen was collected. The upstream long non-coding RNA (lncRNA) and the downstream gene of miR-874-3p were predicted using bioinformatic analysis with the results being ascertained with dual-luciferase reporter assay. The viability, apoptosis, migration and invasion of transfected GC cells with or without cisplatin (DDP) treatment were evaluated by Cell Counting Kit-8 (CCK-8), flow cytometric, Scratch, and Transwell assays. An animal xenograft model was constructed. Expressions of long intergenic non-coding RNA 00922 (LINC00922), miR-874-3p and potential target genes were quantified by quantitative real-time polymerase-chain reaction (qRT-PCR) and Western blot. MiR-874-3p, which was lower-expressed in drug-resistant GC tissues and cells, was upregulated to repress the viability, migration and invasion but enhance the apoptosis and sensitivity in GC cells with or without DDP resistance. Downregulation of miR-874-3p eliminated the effects of silenced LINC00922, a upstream lncRNA of miR-874-3p, on cell viability, apoptosis, migration and invasion, as well as the expressions of Glycerophosphodiester Phosphodiesterase Domain Containing 5 (GDPD5) and the downstream gene of miR-874-3p in DDP-resistant GC cells. GDPD5 silencing diminished the effects of miR-874-3p downregulation on GDPD5 expression, viability, migration and invasion of DDP-resistant GC cells. Additionally, LINC00922 silencing enhanced the inhibitory effect of DDP on tumor growth, whereas reversing the effects of DDP on LINC00922, miR-874-3p and GDPD5 expressions in tumors. MiR-874-3p, an miRNA, which is sponged by LINC00922 and targets GDPD5, inhibits the GC progression yet enhances the DDP sensitivity in GC.

show abstract

“…It sponged miR-874-5p and subsequently up-regulated GDPD5. The latter mediates cleavage of glycosylphosphatidylinositol (GPI)-anchor of target proteins and is involved tumor cell migration, neurite formation and drives spinal motor neuro differentiation (166)(167)(168).…”

Section: Circ Tumor Protein 53 (Circtp53) Up-regulates Cyclindependen...mentioning

confidence: 99%

Up-regulated Circular RNAs in Colorectal Cancer: New Entities for Therapy and Tools for Identification of Therapeutic Targets

Weidle

Nopora

2023

Cancer Genomics Proteomics

View full text Add to dashboard Cite

show abstract

GDPD5, a choline-generating enzyme and its novel role in tumor cell migration

Cited by 6 publications

References 20 publications

Expression of Lipid Metabolism Genes Is Correlated With Immune Microenvironment and Predicts Prognosis in Endometrial Carcinoma

Expression of Lipid Metabolism Genes Is Correlated With Immune Microenvironment and Predicts Prognosis in Endometrial Carcinoma

MiR-874-3p represses the migration and invasion yet promotes the apoptosis and cisplatin sensitivity via being sponged by long intergenic non-coding RNA 00922 (LINC00922) and targeting Glycerophosphodiester Phosphodiesterase Domain Containing 5 (GDPD5) in gastric cancer cells

Up-regulated Circular RNAs in Colorectal Cancer: New Entities for Therapy and Tools for Identification of Therapeutic Targets

Contact Info

Product

Resources

About