GDNF/Ret signaling and the development of the kidney

Costantini, Frank; Shakya, Reena

doi:10.1002/bies.20357

Cited by 274 publications

(229 citation statements)

References 87 publications

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“…This may indeed be the case for FGF and GDNF in the kidney. As mentioned earlier, GDNF can stimulate renal epithelial cell migration in vitro, and ectopic GDNF is sufficient to induce supernumerary ureteric buds [25,58]. Likewise, FGF beads can cause formation of ectopic ureteric buds [143].…”

Section: Role Of Mesenchymal/stromal Cues In Epithelial Branching Mormentioning

confidence: 74%

Comparative Mechanisms of Branching Morphogenesis in Diverse Systems

Sternlicht

Werb

2006

J Mammary Gland Biol Neoplasia

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Much progress has been made in recent years toward understanding mechanisms controlling branching morphogenesis, a fundamental aspect of development in a variety of invertebrate and vertebrate organs. To gain a deeper understanding of how branching morphogenesis occurs in the mammary gland, we compare and contrast the cellular and molecular events underlying this process in both invertebrate and vertebrate organs. Thus, in this review, we focus on the common themes that have emerged from such comparative analyses and discuss how they are implemented via a battery of signaling pathways to ensure proper branching morphogenesis in diverse systems.

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Section: Role Of Mesenchymal/stromal Cues In Epithelial Branching Mormentioning

confidence: 74%

Comparative Mechanisms of Branching Morphogenesis in Diverse Systems

Sternlicht

Werb

2006

J Mammary Gland Biol Neoplasia

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“…4,5 Specific signals from the metanephric mesenchyme (MM) regulate UB outgrowth into MM, a process called induction. Upon reaching the MM, the UB tip undergoes branching morphogenesis to form the collecting system.…”

Section: Urinary System Developmentmentioning

confidence: 99%

“…4 The postnatal expression of GFLs is poorly defined in the kidney. Among the other GFLs, Neurturin is also expressed in the UBs of embryonic kidney after E14.…”

Section: Biological Roles Of Gdnf-gfrα1-ret In Kidney Developmentmentioning

confidence: 99%

The many faces of RET dysfunction in kidney

Jain¹

2009

Organogenesis

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“…On the one hand the nephrogenic mesenchymal stem cells first condensate to form a Comma-shaped and subsequently an S-shaped body [1][2][3]. The cells located in the capsule-orientated part of the S-shaped body form the nephron tubules, while cells orientated towards the medulla generate the glomerulus.…”

Section: Introductionmentioning

confidence: 99%

The tubulogenic effect of aldosterone is attributed to intact binding and intracellular response of the mineralocorticoid receptor

Minuth

Denk

et al. 2007

Open Life Sciences

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Abstract:Little is known about the extra-and intracellular stimuli inducing renal stem/progenitor cells to develop into three-dimensionally structured tubules. To study this specific development in a controlled environment, we used an advanced culture technique. Embryonic tissue derived from neonatal rabbit kidney was placed in a perfusion culture container at the interface of an artificial interstitium made of a polyester fleece. Culture was carried out in chemically defined Iscove's Modified Dulbecco's Medium (IMDM) for 13 days. Development of tubules was histochemically detected on cryosections labeled with Soybean Agglutinin (SBA). The experiments showed that aldosterone exerts a specific tubulogenic effect. Application of aldosterone (1 × 10 −7 M) raised numerous SBA-labeled tubules, while in the absence of the steroid hormone the development of tubules was lacking. Specificity of hormone action was analyzed by the use of aldosterone antagonists. Administration of spironolactone (1 × 10 −4 M) and canrenoate(1 × 10 −5 M) completely inhibited the development of tubules. Finally, disrupting the intracellular molecular complex of the mineralocorticoid receptor (MR) and heat shock proteins by geldanamycin (2 µg/ml) prevented the development of tubules. Our results suggest that the tubulogenic effect induced by aldosterone is attributed to both hormone binding and an undisturbed intracellular response of the MR.

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GDNF/Ret signaling and the development of the kidney

Cited by 274 publications

References 87 publications

Comparative Mechanisms of Branching Morphogenesis in Diverse Systems

Comparative Mechanisms of Branching Morphogenesis in Diverse Systems

The many faces of RET dysfunction in kidney

The tubulogenic effect of aldosterone is attributed to intact binding and intracellular response of the mineralocorticoid receptor

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