GDF15 as a biomarker of ageing

Liu, Huan; Huang, Yun; Lyu, Yongnan; Dai, Wen; Tong, Yongqing

doi:10.1016/j.exger.2021.111228

Cited by 51 publications

(51 citation statements)

References 42 publications

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“…A positive correlation was present in our study between GDF‐15 and age as in Liua et al. that showed a positive correlation between them and GDF ‐15 levels increase with age [32]. There is a positive correlation between GDF‐15, hs CRP, and HOMA‐IR score as in the study of Roy et al.…”

Section: Discussionsupporting

confidence: 80%

“…There was a positive correlation between GDF-15 and CIMT of highly statistically significance (p < 0.001), which is consistent with Sherief et al that showed increased GDF-15 with CIMT in thalassemic patients. A positive correlation was present in our study between GDF-15 and age as in Liua et al that showed a positive correlation between them and GDF -15 levels increase with age[32]. There is a positive correlation between GDF-15, hs CRP, and HOMA-IR score as in the study of Roy et al that showed the same results and identified that GDF15 levels as marker of T2DM in obese patients[33].…”

supporting

confidence: 83%

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GDF‐15 is associated with atherosclerosis in adults with transfusion‐dependent beta‐thalassemia

Efat

Wahb

Shoeib

et al. 2022

eJHaem

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Objectives: To study serum growth differentiation factor‐15 (GDF‐15) serum level in β‐thalassemia patients and its relation to carotid intima‐media thickness. Background: Thalassemia is a common genetic disease resulting in decreased beta‐chains, leading to manifested anemia. It may be subsequently complicated by iron overload, which induces numerous morbidities and even death. Growth differentiation factor‐15 (GDF‐15) is a strong and independent predictor of mortality and disease progression in patients with atherosclerosis alongside with carotid‐intimal media thickness (CIMT). Patients and methods: This monocentric case‐control study was done on 90 subjects in the period from January 2020 to March 2021. Sixty transfusion‐dependent beta‐thalassemia (TDβT) cases (≥18 years) were selected from the thalassemia clinic of Hematology division at Menoufia University hospitals. We included also 30 sex and age matched healthy as the controls. Routine investigations were done beside. Serum GDF‐15 was measured by ELISA. CIMT was measured by Doppler Ultrasonography. Results: CIMT on both sides was statistically significant higher in cases (median of 0.08 cm) than in the controls (median of 0.04). GDF‐15 was also significantly higher in cases (median of 1839.89 pg/dl) than in controls (median of 256.14 pg/dl). So, we found that GDF‐15 is a predictor of and associated with atherosclerosis in thalassemic adults (OR = 39.198, p value 0.008, 95% CI: 2.576–596.5). Conclusion: GDF‐ 15 is increased in TDβT. CIMT (as a marker of subclinical atherosclerosis) is increased in these patients alongside with GDF‐15, is a predictor, and associated with atherosclerosis in thalassemic adults.

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Section: Discussionsupporting

confidence: 80%

supporting

confidence: 83%

GDF‐15 is associated with atherosclerosis in adults with transfusion‐dependent beta‐thalassemia

Efat

Wahb

Shoeib

et al. 2022

eJHaem

View full text Add to dashboard Cite

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“…Being a stress-inducible cytokine, GDF-15 is upregulated by several proteins associated with stress and inflammation, such as IL-1β, TNF-α, IL-2, and macrophage colony-stimulating factor (MCSF-1), suggesting a complex tissue-specific regulation [ 115 ]. GDF-15 levels increase with age, which is why it has been proposed as a potential biomarker of aging and mitochondrial dysfunction [ 76 , 116 ]. In a previous study that evaluated older patients with chronic kidney disease, it was observed that there was a correlation between age and GDF-15 levels, which could serve as a precedent to evaluate the relationship between high levels of GDF-15 and frailty in extensive cohorts [ 117 ].…”

Section: Blood Biomarkers Associated With Frailtymentioning

confidence: 99%

Frailty in Aging and the Search for the Optimal Biomarker: A Review

et al. 2022

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In the context of accelerated aging of the population worldwide, frailty has emerged as one of the main risk factors that can lead to loss of self-sufficiency in older people. This syndrome is defined as a reduced state of physiological reserve and functional capacity. The main diagnostic tools for frailty are based on scales that show deficits compared to their clinical application, such as the Fried frailty phenotype, among others. In this context, it is important to have one or more biomarkers with clinical applicability that can objectively and precisely determine the degree or risk of frailty in older people. The objective of this review was to analyze the biomarkers associated with frailty, classified according to the pathophysiological components of this syndrome (inflammation, coagulation, antioxidants, and liver function, among others). The evidence demonstrates that biomarkers associated with inflammation, oxidative stress, skeletal/cardiac muscle function, and platelet function represent the most promising markers of frailty due to their pathophysiological association with this syndrome. To a lesser extent but with the possibility of greater innovation, biomarkers associated with growth factors, vitamins, amino acids, and miRNAs represent alternatives as markers of this geriatric syndrome. Likewise, the incorporation of artificial intelligence represents an interesting approach to strengthening the diagnosis of frailty by biomarkers.

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“…Growth differentiation factor 15 (GDF15), which belongs to the transforming growth factor (TGFB) superfamily [1], is strongly associated with several diseases such as obesity, cancer and cardiovascular diseases as well as with aging [2][3][4]. Under physiological conditions, GDF15 is only weakly expressed in most tissues, whereas pathological states and cellular stress strongly increase GDF15 levels [5][6][7], suggesting it as potential biomarker.…”

Section: Introductionmentioning

confidence: 99%

GDF15 Supports the Inflammatory Response of PdL Fibroblasts Stimulated by P. gingivalis LPS and Concurrent Compression

Stemmler

Symmank

Steinmetz

et al. 2021

IJMS

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Periodontitis is characterized by bacterially induced inflammatory destruction of periodontal tissue. This also affects fibroblasts of the human periodontal ligaments (HPdLF), which play a coordinating role in force-induced tissue and alveolar bone remodeling. Excessive inflammation in the oral tissues has been observed with simultaneous stimulation by pathogens and mechanical forces. Recently, elevated levels of growth differentiation factor 15 (GDF15), an immuno-modulatory member of the transforming growth factor (TGFB) superfamily, were detected under periodontitis-like conditions and in force-stressed PdL cells. In view of the pleiotropic effects of GDF15 in various tissues, this study aims to investigate the role of GDF15 in P. gingivalis-related inflammation of HPdLF and its effect on the excessive inflammatory response to concurrent compressive stress. To this end, the expression and secretion of cytokines (IL6, IL8, COX2/PGE2, TNFα) and the activation of THP1 monocytic cells were analyzed in GDF15 siRNA-treated HPdLF stimulated with P. gingivalis lipopolysaccharides alone and in combination with compressive force. GDF15 knockdown significantly reduced cytokine levels and THP1 activation in LPS-stimulated HPdLF, which was less pronounced with additional compressive stress. Overall, our data suggest a pro-inflammatory role for GDF15 in periodontal disease and demonstrate that GDF15 partially modulates the force-induced excessive inflammatory response of PdLF under these conditions.

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GDF15 as a biomarker of ageing

Cited by 51 publications

References 42 publications

GDF‐15 is associated with atherosclerosis in adults with transfusion‐dependent beta‐thalassemia

GDF‐15 is associated with atherosclerosis in adults with transfusion‐dependent beta‐thalassemia

Frailty in Aging and the Search for the Optimal Biomarker: A Review

GDF15 Supports the Inflammatory Response of PdL Fibroblasts Stimulated by P. gingivalis LPS and Concurrent Compression

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