Gdf11 Overexpression Alleviates Sepsis-Induced Lung Microvascular Endothelial Barrier Damage by Activating Sirt1/Nox4 Signaling to Inhibit Ferroptosis
Zhixiang Wu,
Qiong Xi,
Qin Zhao
et al.
Abstract:Sepsis is a lethal clinical syndrome, and acute lung injury (ALI) is the earliest and most serious complication. We aimed to explore the role of growth differentiation factor 11 (GDF11) in sepsis-induced dysfunction of lung microvascular endothelial barrier in vivo and in vitro to elucidate its potential mechanism related to sirtuin 1 (SIRT1)/NADPH oxidase 4 (NOX4) signaling. Cecal ligation and puncture (CLP)-induced sepsis mice and lipopolysaccharide (LPS)-induced pulmonary microvascular endothelial cells (PM… Show more
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