GDF11 as a friend or an enemy in the cancer biology?

Król, Wojciech; Machelak, Weronika; Zielińska, Marta

doi:10.1016/j.bbcan.2023.188944

Cited by 3 publications

(2 citation statements)

References 80 publications

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“…Furthermore, VIPR2 has been shown to form homodimers and oligomers, which are involved in VIP-induced cancer cell migration (81). The expression of GNG11 mRNA is down-regulated in ovarian cancer patients, and its high expression is associated with poor prognosis (82). GNG11 may play a crucial role in the biological process of ovarian cancer through the ECM-receptor interaction pathway (83).…”

Section: Discussionmentioning

confidence: 99%

Identification of Key Regulators in Pancreatic Ductal Adenocarcinoma using Network theoretical Approach

Bhattacharjee,

Ghosh

2024

Preprint

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Pancreatic Ductal Adenocarcinoma (PDAC) is a devastating disease with poor clinical outcomes which is mainly because of delayed disease detection resistance to chemotherapy and lack of specific targeted therapies. The disease's development involves complex interactions among immunological, genetic, and environmental factors, yet its molecular mechanism remains elusive. A major challenge in understanding PDAC etiology lies in unraveling the genetic profiling that governs the PDAC network. To address this, we examined the gene expression profile of PDAC and compared it with that of healthy controls, identifying differentially expressed genes (DEGs). These DEGs formed the basis for constructing the PDAC protein interaction network, and their network topological properties were calculated. It was found that the PDAC network self-organizes into a scale-free fractal state with weakly hierarchical organization. Newman and Girvan algorithm (leading eigenvector (LEV) method) of community detection enumerated four communities leading to at least one motif. Our analysis revealed 33 key regulators were predominantly enriched in neuroactive ligand-receptor interaction, Cell adhesion molecules, Leukocyte transendothelial migration pathways; positive regulation of cell proliferation, positive regulation of protein kinase B signaling biological functions; G-protein beta-subunit binding, receptor binding molecular functions etc. Transcription Factor and mi-RNA of the key regulators were obtained. Recognizing the therapeutic potential and biomarker significance of PDAC Key regulators, we also identified approved drugs for specific genes. However, it is imperative to subject Key regulators to experimental validation to establish their efficacy in the context of PDAC.

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Section: Discussionmentioning

confidence: 99%

Identification of Key Regulators in Pancreatic Ductal Adenocarcinoma using Network theoretical Approach

Bhattacharjee,

Ghosh

2024

Preprint

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“… 27 Emerging research has substantiated the crucial regulatory role of GDF11 in metabolic disorders, cancer, and COPD. 28 , 29 Notably, Onodera et al have reported significantly diminished plasma GDF11 levels in COPD patients compared to healthy individuals. 29 Furthermore, Tang et al have demonstrated that cigarette smoke extract expedite COPD progression by suppressing GDF11 expression, and similar outcomes were observed upon GDF11 knockdown.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Effects of Lifei Decoction in a Murine Model of COPD Induced by LPS and Cigarette Smoke

Lu,

Zhu,

et al. 2024

COPD

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Introduction The Lifei Decoction (LD) is a commonly utilized Chinese medicine for the treatment of sepsis and bronchial inflammation. However, its therapeutic potential in chronic obstructive pulmonary disease (COPD) remains unknown. Therefore, the objective of this study was to investigate the therapeutic efficacy and underlying mechanism of LD in a mouse model of COPD induced by cigarette smoke (CS) combined with lipopolysaccharide (LPS). Methods Hematoxylin-eosin (H&E) staining was employed to observe the pathological alterations in lung tissue, while ELISA was utilized for the detection of levels of inflammatory factors in both lung tissue and bronchoalveolar lavage fluid (BALF). Additionally, Western blot analysis was conducted to assess the expression of p-NF-κB, GDF11, ZO-1, and Occludin-1 proteins. The changes in intestinal flora were evaluated using the viable bacteria count method. Results The administration of LD demonstrates significant efficacy in mitigating pulmonary tissue damage in a murine model, while concurrently inhibiting the activation of the inflammatory pathway NF-κB to attenuate the levels of pro-inflammatory factors. Moreover, LD exhibits the capacity to enhance the expression of intestinal functional proteins ZO-1 and Occludin-1, thereby rectifying dysbiosis within the gut microbiota. Conclusion The LD shows great promise as a potential treatment for COPD.

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Expression and Significance of the GDF11 Protein in Ureteropelvic Junction Obstruction (UPJO)

Lao,

Shi,

Chen

et al. 2024

Preprint

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Background To explore the expression of growth differentiation factor 11 (GDF11), a member of the TGF-β superfamily, in pediatric ureteropelvic junction obstruction (UPJO) patients. Methods Five patients diagnosed with severe neonatal hydronephrosis underwent laparoscopic pyeloplasty between January 2021 and November 2022. Tissue samples from the constricted ureteropelvic junction and adjacent normal ureteral segments served as controls. The presence of the GDF11 protein in these tissues was examined using immunohistochemistry and Western blot techniques. Subsequently, a statistical analysis compared the protein expression levels in both groups. Results Immunohistochemical staining revealed that the frequency of high GDF11 protein expression in the narrowed ureter (60%) was significantly greater than that in the normal ureter (40%). Western blot analysis indicated that the expression of GDF11 was significantly greater in the narrowed ureter than in the normal ureter. Conclusions The increased expression of GDF11 in UPJO is noteworthy and deserves clinical attention.

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GDF11 as a friend or an enemy in the cancer biology?

Cited by 3 publications

References 80 publications

Identification of Key Regulators in Pancreatic Ductal Adenocarcinoma using Network theoretical Approach

Identification of Key Regulators in Pancreatic Ductal Adenocarcinoma using Network theoretical Approach

Therapeutic Effects of Lifei Decoction in a Murine Model of COPD Induced by LPS and Cigarette Smoke

Expression and Significance of the GDF11 Protein in Ureteropelvic Junction Obstruction (UPJO)

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