Gd-EOB-DTPA-enhanced T1ρ imaging vs diffusion metrics for assessment liver inflammation and early stage fibrosis of nonalcoholic steatohepatitis in rabbits

Xie, Yuanliang; Zhang, Hongfeng; Jin, Chaoling; Wang, Xiang; Wang, Xiaoqi; Chen, Jingting; Xu, Yikai

doi:10.1016/j.mri.2017.12.017

Cited by 16 publications

(15 citation statements)

References 38 publications

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“…Our results showed that liver T1rho values increased gradually after the injection of CCl 4 and decreased gradually after withdrawal of CCl 4 injection. These findings highlight the potential value of T1rho for monitoring liver injury in a CCl 4 -induced fibrosis model, as has been indicated in previous studies [16,17]. However, in the fibrosis group, we found that the liver T1rho values at week 4 were slightly lower than those at week 2, which was inconsistent with a previous study reported by Zhao et al [23] A possible explanation may be that the liver tissue edema and cellular swelling in our experimental rats was more severe at week 2.…”

Section: Discussionsupporting

confidence: 81%

“…T1rho is sensitive to low frequency motional and static processes and can be used to investigate the macromolecular composition and proton exchange in tissues [14][15][16]. Experimental studies have demonstrated the potential of T1rho MR imaging for monitoring liver injury, diagnosing and staging liver fibrosis, and grading inflammatory activity [17][18][19][20][21][22][23][24]. Furthermore, clinical studies have demonstrated the potential of T1rho MR imaging for detecting and characterizing liver fibrosis, liver cirrhosis, and liver function [25][26][27][28][29].…”

Section: Introductionmentioning

confidence: 99%

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Liver injury monitoring, fibrosis staging and inflammation grading using T1rho magnetic resonance imaging: an experimental study in rats with carbon tetrachloride intoxication

Xie

et al. 2020

BMC Gastroenterol

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Background: To investigate the merit of T1rho relaxation for the evaluation of liver fibrosis, inflammatory activity, and liver injury monitoring in a carbon tetrachloride (CCl 4)-induced rat model. Methods: Model rats from CCl 4-induced liver fibrosis (fibrosis group: n = 41; regression group: n = 20) and control (n = 11) groups underwent black blood T1rho magnetic resonance (MR) imaging (MRI). Injection of CCl 4 was done twice weekly for up to 12 weeks in the fibrosis group and for up to 6 weeks in the regression group. MR scanning time points were at baseline and at 2, 4, 6, 8, 10 and 12 weeks after CCl 4 injection in the fibrosis group and at baseline and at 2, 4, 6 (CCl 4 withdrawal), 7, 8, 10 and 12 weeks in the regression group. Results: In the fibrosis group, liver T1rho values increased gradually within week 8 and then decreased. In the regression group, T1rho values dropped gradually after the withdrawal of CCl 4 and fell below those at baseline. The T1rho values at S0 were lower than those at any other stage (all P < 0.05). The T1rho values at G0 were significantly lower than those at any other grade, and G1 was lower than G2 (all P < 0.01). The T1rho values mildly correlated with fibrosis stages (r = 0.362) and moderately correlated with grades of inflammation (r = 0.568). The T1rho values of rats with the same inflammation grades showed no significant difference among different fibrosis stages, and the T1rho values at S3 showed a significant difference among different grades of inflammation (P = 0.024). Inflammation grade was an independent variable associated with T1rho values (P < 0.001). Conclusion: T1rho MRI can be used to monitor CCl 4-induced liver injury, and inflammatory activity had a greater impact on liver T1rho values than fibrosis.

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Section: Discussionsupporting

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Liver injury monitoring, fibrosis staging and inflammation grading using T1rho magnetic resonance imaging: an experimental study in rats with carbon tetrachloride intoxication

Xie

et al. 2020

BMC Gastroenterol

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“…Therefore, noninvasive, comprehensive and accurate methods of diagnosing liver fibrosis are required. In recent years, noninvasive methods have been increasingly used, such as serological examination[ 13 ], ultrasound-based elastography[ 14 ], diffusion-weighted imaging (DWI)[ 15 ], magnetic resonance enterography (MRE)[ 16 ], T1 rho[ 17 ] and texture analysis[ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Quantitative assessment of hepatic fibrosis in chronic hepatitis B and C: T1 mapping on Gd-EOB-DTPA-enhanced liver magnetic resonance imaging

Pan¹,

Wang²,

Guo³

2018

WJG

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AIMTo assess the accuracy of Look-Locker on gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) for staging liver fibrosis in chronic hepatitis B/C (CHB/C).METHODSWe prospectively included 109 patients with CHB or CHC who underwent a 3.0-Tesla MRI examination, including T1-weighted and Look-Locker sequences for T1 mapping. Hepatocyte fractions (HeF) and relaxation time reduction rate (RE) were measured for staging liver fibrosis. A receiver operating characteristic analysis using the area under the receiver operating characteristic curve (AUC) was used to compare the diagnostic performance in predicting liver fibrosis between HeF and RE.RESULTSA total of 73 patients had both pathological results and MRI information. The number of patients in each fibrosis stage was evaluated semiquantitatively according to the METAVIR scoring system: F0, n = 23 (31.5%); F1, n = 19 (26.0%); F2, n = 13 (17.8%); F3, n = 6 (8.2%), and F4, n = 12 (16.4%). HeF by EOB enhancement imaging was significantly correlated with fibrosis stage (r = -0.808, P < 0.05). AUC values for diagnosis of any (≥ F1), significant (≥ F2) or advanced (≥ F3) fibrosis, and cirrhosis (F4) using HeF were 0.837 (0.733-0.913), 0.890 (0.795-0.951), 0.957 (0.881-0.990), and 0.957 (0.882-0.991), respectively. HeF measurement was more accurate than use of RE in establishing liver fibrosis staging, suggesting that calculation of HeF is a superior noninvasive liver fibrosis staging method.CONCLUSIONA T1 mapping-based HeF method is an efficient diagnostic tool for the staging of liver fibrosis.

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“…1) with the reader blinded to the underlying condition and laboratory data:Three circular regions of interests (ROIs) were manually placed on each slice of the T1ρ map using Visage 7.1.4 (Visage Imaging, Richmond, NSW, Australia). Many publications have already used this method 13,16,17,26–29 . In this project we have kept to the instructions of these publications.…”

Section: Methodsmentioning

confidence: 99%

Combined morphological and functional liver MRI using spin-lattice relaxation in the rotating frame (T1ρ) in conjunction with Gadoxetic Acid-enhanced MRI

Stief

Haase

Lüdemann

et al. 2019

Sci Rep

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Noninvasive early detection of liver cirrhosis and fibrosis is essential for management and therapy. The aim was to investigated whether a combination of the functional parameter relative enhancement (RE) on Gadoxetic Acid magnetic resonance imaging (Gd-EOB-DTPA-enhanced MRI) and the fibrosis parameter T1ρ distinguishes cirrhosis and healthy liver. We analyzed patients with Gd-EOB-DTPA-enhanced MRI and T1ρ mapping. Signal intensity was measured before and after contrast; RE was calculated. T1ρ was measured with circular regions of interest (T1ρ-cROI). A quotient of RE and T1ρ-cROI was calculated: the fibrosis function quotient (FFQ). Cirrhosis was evaluated based on morphology and secondary changes. 213 datasets were included. The difference between cirrhotic and noncirrhotic liver was 51.11 ms vs. 47.56 ms for T1ρ-cROI (p < 0.001), 0.59 vs. 0.70 for RE (p < 0.001), and 89.53 vs. 70.83 for FFQ (p < 0.001). T1ρ-cROI correlated with RE, r = −0.14 (p < 0.05). RE had an AUC of 0.73. The largest AUC had the FFQ with 0.79. The best cutoff value was 48.34 ms for T1ρ-cROI, 0.70 for RE and 78.59 ms for FFQ. In conclusion T1ρ and RE can distinguish between cirrhotic and noncirrhotic liver. The FFQ, which is the combination of the two, improves diagnostic performance.

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Gd-EOB-DTPA-enhanced T1ρ imaging vs diffusion metrics for assessment liver inflammation and early stage fibrosis of nonalcoholic steatohepatitis in rabbits

Cited by 16 publications

References 38 publications

Liver injury monitoring, fibrosis staging and inflammation grading using T1rho magnetic resonance imaging: an experimental study in rats with carbon tetrachloride intoxication

Liver injury monitoring, fibrosis staging and inflammation grading using T1rho magnetic resonance imaging: an experimental study in rats with carbon tetrachloride intoxication

Quantitative assessment of hepatic fibrosis in chronic hepatitis B and C: T1 mapping on Gd-EOB-DTPA-enhanced liver magnetic resonance imaging

Combined morphological and functional liver MRI using spin-lattice relaxation in the rotating frame (T1ρ) in conjunction with Gadoxetic Acid-enhanced MRI

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