Gd-EOB-DTPA-Enhanced MR Imaging of the Liver: The Effect on T2 Relaxation Times and Apparent Diffusion Coefficient (ADC)

Cieszanowski, Andrzej; Podgórska, Joanna; Rosiak, Grzegorz; Maj, Edyta; Grudziński, Ireneusz P.; Kaczynski, Bartosz; Szeszkowski, Wojciech; Milczarek, Krzysztof; Rowiński, Olgierd

doi:10.12659/pjr.895701

Cited by 7 publications

(4 citation statements)

References 19 publications

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“…Thus, DKI might also be beneficial in the differentiation and classification of focal liver lesions based on their structural complexity. Even though recent studies showed that DWI can be acquired before or after contrast media injection with no relevant effect on quantitative ADC values (19), we chose to analyze both groups separately. This was done as the influence of contrast agent administration on DKI values in this setting is not known.…”

Section: Discussionmentioning

confidence: 99%

Diffusion kurtosis imaging of the liver at 3 Tesla: in vivo comparison to standard diffusion-weighted imaging

et al. 2017

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Background Functional techniques like diffusion-weighted imaging (DWI) are gaining more and more importance in liver magnetic resonance imaging (MRI). Diffusion kurtosis imaging (DKI) is an advanced technique that might help to overcome current limitations of DWI. Purpose To evaluate DKI for the differentiation of hepatic lesions in comparison to conventional DWI at 3 Tesla. Material and Methods Fifty-six consecutive patients were examined using a routine abdominal MR protocol at 3 Tesla which included DWI with b-values of 50, 400, 800, and 1000 s/mm. Apparent diffusion coefficient maps were calculated applying a standard mono-exponential fit, while a non-Gaussian kurtosis fit was used to obtain DKI maps. ADC as well as Kurtosis-corrected diffusion ( D) values were quantified by region of interest analysis and compared between lesions. Results Sixty-eight hepatic lesions (hepatocellular carcinoma [HCC] [n = 25]; hepatic adenoma [n = 4], cysts [n = 18]; hepatic hemangioma [HH] [n = 18]; and focal nodular hyperplasia [n = 3]) were identified. Differentiation of malignant and benign lesions was possible based on both DWI ADC as well as DKI D-values ( P values were in the range of 0.04 to < 0.0001). Conclusion In vivo abdominal DKI calculated using standard b-values is feasible and enables quantitative differentiation between malignant and benign liver lesions. Assessment of conventional ADC values leads to similar results when using b-values below 1000 s/mm for DKI calculation.

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Section: Discussionmentioning

confidence: 99%

Diffusion kurtosis imaging of the liver at 3 Tesla: in vivo comparison to standard diffusion-weighted imaging

et al. 2017

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“…Unlike previous reports that only discussed one single ADC value, this study evaluated the ADCs at four b-values (50, 800, 1,000, and 1,200 s/mm 2 ), and found no difference between the ADCs before and after enhancement, indicating that the ADC values of focal hepatic lesions would not be affected by Gd-EOB-DTPA, regardless of whether this was a high b-value or low b-value DWI. However, unlike hepatic lesions, the post-contrast ADC values of normal hepatic parenchyma were significantly lower than those pre-contrast, which was speculated to be related to the uptake of Gd-EOB-DTPA by normal liver tissue (5)(6)(7).…”

Section: Discussionmentioning

confidence: 92%

“…Several strategies have been used to overcome this problem, including shortening the delay time of the HBP (4) and optimizing the scanning of the magnetic resonance (MR) protocol (5)(6)(7)(8)(9). Of these, the adjustment of the diffusion weighted imaging (DWI) sequence scanning order from pre-contrast to post-contrast is feasible and crucial.…”

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confidence: 99%

Identification of diffusion weighted imaging would be affected before and after Gd-EOB-DTPA in patients with focal hepatic lesions: an observational study

et al. 2022

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Background: Inserting diffusion weighted imaging (DWI) into the time interval between post contrast and hepatobiliary phase (HBP) is time saving and health economic friendly. However, whether DWI would be affected before and after Gd-EOB-DTPA is still unknown. This study aims to validate whether the DWI at both low and high b-values is affected before and after Gd-EOB-DTPA enhancement.Methods: From July 2019 to November 2019, seventy-three patients who satisfied the inclusion criteria were enrolled. Those patients were scanned with multiple b-value (b-value of 0, 50, 800, 1,000, and 1,200 s/mm 2 ) DWI using a 3.0 T magnetic resonance (MR) scanner before and after the injection of Gd-EOB-DTPA. The final imaging diagnosis of the malignant liver lesions were made by histopathological analysis. The lesionliver contrast intensity ratio (CIR) and the apparent diffusion coefficients (ADCs) of hepatic parenchyma and lesions at each b-value was evaluated. The Student's t-test or Mann-Whitney U test was used to compare the CIR and ADC between the MR images before and after contrast agent injection. In addition, the Student's t-test or Mann-Whitney U test was used to compare the ADC values between benign and malignant lesions.Receiver operating characteristics (ROC) curves were used to assess the area under the curve (AUC) of the ADC values in differentiating between benign and malignant lesions.Results: For the CIRs comparison, the CIRs showed no statistical significance before and after Gd-EOB-

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“…Ab-MRI protocols should enable a reduction in imaging acquisition time, as noted by Canellas et al [ 12 ], who reported that Ab-MRI protocols may be performed in less than 15 min, while standard liver MRI takes up to 30 min. The implementation of Ab-MRI protocols can be expected because they have shown no significant influence on gadoxetic acid administration on T2-weighted imaging and diffusion sequences in regard to acquisition and image interpretation[ 29 , 30 ], suggesting that patients could undergo contrast administration without a bolus injection before entering the MRI suite. This would not only reduce the imaging acquisition time, but also provide several other advantages.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic performance of abbreviated gadoxetic acid-enhanced magnetic resonance protocols with contrast-enhanced computed tomography for detection of colorectal liver metastases

Ozaki¹,

Ishida²,

Higuchi³

et al. 2022

World J Radiol

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BACKGROUND Although contrast-enhanced magnetic resonance imaging (MRI) using gadoxetic acid has been shown to have higher accuracy, sensitivity, and specificity for the detection and characterization of hepatic metastases compared with other modalities, the long examination time would limit the broad indication. Several abbreviated enhanced MRI (Ab-MRI) protocols without dynamic phases have been proposed to achieve equivalent diagnostic performance for the detection of colorectal liver metastases. However, an optimal protocol has not been established, and no studies have assessed the diagnostic performance of Ab-MRI combined with contrast-enhanced computed tomography (CE-CT), which is the preoperative imaging of colorectal cancer staging in clinical settings, to determine the best therapeutic strategy. AIM To compare the diagnostic performance of two kinds of Ab-MRI protocol with the standard MRI protocol and a combination of the Ab-MRI protocol and CE-CT for the detection of colorectal liver metastases. METHODS Study participants comprised 87 patients (51 males, 36 females; mean age, 67.2 ± 10.8 years) who had undergone gadoxetic acid-enhanced MRI and CE-CT during the initial work-up for colorectal cancer from 2010 to 2021. Each exam was independently reviewed by two readers in three reading sessions: (1) Only single-shot fast spin echo (FSE) T2-weighted or fat-suppressed-FSE-T2-weighted, diffusion-weighted, and hepatobiliary-phase images (Ab-MRI protocol 1 or 2); (2) all acquired MRI sequences (standard protocol); and (3) a combination of an Ab-MRI protocol (1 or 2) and CE-CT. Diagnostic performance was then statistically analyzed. RESULTS A total of 380 Lesions were analyzed, including 195 metastases (51.4%). Results from the two Ab-MRI protocols were similar. The sensitivity, specificity, and positive and negative predictive values from Ab-MRI were non-inferior to those from standard MRI ( P > 0.05), while those from the combination of Ab-MRI protocol and CE-CT tended to be higher than those from Ab-MRI alone, although the difference was not significant ( P > 0.05), and were quite similar to those from standard MRI ( P > 0.05). CONCLUSION The diagnostic performances of two Ab-MRI protocols were non-inferior to that of the standard protocol. Combining Ab-MRI with CE-CT provided better diagnostic performance than Ab-MRI alone.

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Gd-EOB-DTPA-Enhanced MR Imaging of the Liver: The Effect on T2 Relaxation Times and Apparent Diffusion Coefficient (ADC)

Cited by 7 publications

References 19 publications

Diffusion kurtosis imaging of the liver at 3 Tesla: in vivo comparison to standard diffusion-weighted imaging

Diffusion kurtosis imaging of the liver at 3 Tesla: in vivo comparison to standard diffusion-weighted imaging

Identification of diffusion weighted imaging would be affected before and after Gd-EOB-DTPA in patients with focal hepatic lesions: an observational study

Diagnostic performance of abbreviated gadoxetic acid-enhanced magnetic resonance protocols with contrast-enhanced computed tomography for detection of colorectal liver metastases

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