Gd-EOB-DTPA-enhanced MR Imaging Findings of Hepatocellular Adenoma: Correlation with Pathological Findings

Takara, Kenichi; Saito, Kazuhiro; Kusama, Hiroshi; Tsuchida, Akihiko; Aoki, Tatsuya; Nagao, Toshitaka; Imai, Yumiko; Taira, Junichi; Tokuuye, Koichi

doi:10.2463/mrms.10.245

Cited by 6 publications

(2 citation statements)

References 10 publications

(16 reference statements)

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“…HA is a benign neoplasm composed of hepatocytes and is treated with surgical resection if the HA is considered at high risk for spontaneous hemorrhage or malignant transformation. 30,32,39,58 Recent studies have provided evidence that gadoxetic acid-enhanced MR imaging in general and hepatocyte phase images in particular greatly facilitate the diŠerential diagnosis of these 2 lesions. Most FNHs are strongly enhanced during the arterial phase and show hyperintensity on hepatocyte phase images (Fig.…”

Section: Distinguishing Between Focal Nodular Hyperplasia (Fnh) and Hmentioning

confidence: 99%

Rules, Roles, and Room for Discussion in Gadoxetic Acid-enhanced Magnetic Resonance Liver Imaging: Current Knowledge and Future Challenges

Ichikawa

Araki

2013

magn reson med sci

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Since its launch onto the world medical market, gadoxetic acid has received a great deal of attention from a diverse group of researchers, including gastroenterologists, hepatologists, and abdominal radiologists. Gadoxetic acid in liver magnetic resonance (MR) imaging might be considered to have excellent utility. However, several issues remain that radiologists should keep in mind when utilizing this product. We compiled this review to introduce gadoxetic acid, describe how it should be used, highlight the situations in which it is most and least reliable, and suggest potential avenues for future research.

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Section: Distinguishing Between Focal Nodular Hyperplasia (Fnh) and Hmentioning

confidence: 99%

Rules, Roles, and Room for Discussion in Gadoxetic Acid-enhanced Magnetic Resonance Liver Imaging: Current Knowledge and Future Challenges

Ichikawa

Araki

2013

magn reson med sci

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“…This improves the diagnostic confidence for FNH, especially if the lesion shows atypical features on conventional MR imaging. By contrast, hepatic adenomas are usually hypointense to the liver in the hepatocellular phase of Gd-EOB-DTPA imaging, but may show weak or heterogeneous enhancement [ 11 , 12 ] . One of the potential pitfalls of over-reliance on hepatocellular phase imaging is that haemangiomas are hypointense in this phase of enhancement, and may be mistaken for malignant disease.…”

mentioning

confidence: 99%

Liver-specific contrast agents

Koh¹

2012

Cancer Imaging

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In the patient with cancer, magnetic resonance imaging is increasingly used as a diagnostic tool for disease detection, lesion characterization, as well as the assessment of treatment response. Although non-contrast T1-weighted and T2-weighted imaging, together with low molecular weight extracellular gadolinium contrast-enhanced T1-weighted magnetic resonance imaging remain the cornerstone for liver assessment, there is increasing recognition of the benefits of liver-specific contrast agents for disease evaluation.

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A case of inflammatory hepatocellular adenoma displaying an unusual histological pattern

Kanda

Furuta

Motoi

et al. 2015

Clin J Gastroenterol

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Hepatocellular adenoma (HCA) is a rare type of liver tumor. Here, we report a variant case of HCA in a 56-year-old Japanese man which displayed unusual histological features. The patient had undergone surgery for esophageal and gastric cancer 2 years prior. A computed tomography scan performed in the follow-up period detected a single lesion (diameter 1.4 cm) in the right posterior lobe of the liver, leading to a partial hepatectomy. Histologically, the lesion was composed of two different types of cells. The larger cells, which accounted for most of the cells in the tumor, exhibited granular and eosinophilic cytoplasm, large nuclei and apparent nucleoli. These cells, which were designated the common cells, were typical of the HCA. The other cells, which were designated the pyknotic cells, were smaller, possessed an eosinophilic, homogeneous cytoplasm and pyknotic small nuclei, but did not contain nucleoli. Immunohistochemically, the common cells reacted strongly positive for C-reactive protein and serum amyloid A, which is compatible with a diagnosis of inflammatory HCA; in contrast, the pyknotic cells tested negative for these molecules. Since the pyknotic cells tested positive for several markers of apoptosis, they were considered to be apoptotic. In addition, as the common cells demonstrated a higher ki-67 labeling index, the lesion was considered to display upregulated cell kinetics, i.e. increases in both cell growth and death. Although HCA is a rare type of tumor, there have been several reports on HCA variants. The case reported here is that of a new type of HCA variant that demonstrated an unusual histological pattern and upregulated cell kinetics.

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Gd-EOB-DTPA-enhanced MR Imaging Findings of Hepatocellular Adenoma: Correlation with Pathological Findings

Cited by 6 publications

References 10 publications

Rules, Roles, and Room for Discussion in Gadoxetic Acid-enhanced Magnetic Resonance Liver Imaging: Current Knowledge and Future Challenges

Rules, Roles, and Room for Discussion in Gadoxetic Acid-enhanced Magnetic Resonance Liver Imaging: Current Knowledge and Future Challenges

Liver-specific contrast agents

A case of inflammatory hepatocellular adenoma displaying an unusual histological pattern

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