Gd 5 ( Si , Ge ) 4 and Gd2C compounds: Candidates for hyperthermia treatment of cancer

Abstract

A number of Gd based compounds have been investigated for their potential for use in hyperthermia treatment of cancer. The use of magnetic nanoparticles for producing local heating via alternating magnetic fields in cancer affected areas of the body has been an object of numerous studies in recent years. Whereas most studies have focused on using Fe and Co based nanoparticles, we have investigated a number of Gd compounds and alloys for their possible applications in hyperthermia treatment of cancer. Our results suggest that several of these alloys exhibit desired properties for such applications and may have advantages over Fe and Co based alloys for such applications.

R5T4 Compounds

“…Gd 5 Si 2 Ge 2 shows a sharp first-order peak on its heat capacity data at T C ( Fig. For example, high magnetization and T C that may be easily tuned between 40 and 45 C are desired properties for materials potentially suitable for a hypothermal treatment of inoperable tumors (Ahmad and Shaheen, 2009;Ahmad et al, 2005). On the other hand, in the Si-rich region (x > 2, no GMCE) the heat capacity at the transition shows a textbook l-shaped anomaly that reflects the second order of the transition .…”

Ni1‐xCrx alloy for self controlled magnetic hyperthermia

“…Synthesis of magnetic materials that are not affected by alternating magnetic fields above 319 K has become essential in order to prevent over heating of normal cells [3,9]. Iron oxide [10,11], cobalt-palladium [5,12], nickel-copper [12,13], and gadolinium based compounds [14] have been investigated for use in localized hyperthermia treatment of cancer using alternating magnetic field. In this study, the magnetic properties of nickel-chromium alloys for hyperthermia treatment of cancer are investigated for the first time.…”

Electron correlation effects on the magnetostructural transition and magnetocaloric effect inGd5Si2Ge2

“…Following this discovery, Gd 5 Si x Ge 4−x and related R 5 Si x Ge 4−x materials have enjoyed a broad interest. [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] Physical fundamentals governing their potent magnetocaloric effect and other magnetoresponsive effects, such as the giant magnetoresistance and the colossal magnetostriction were discovered 5,6 soon after the giant magnetocaloric effect was reported.…”