GCN5L1-mediated acetylation prevents Rictor degradation in cardiac cells after hypoxic stress
Paramesha Bugga,
Janet R. Manning,
Bellina A.S. Mushala
et al.
Abstract:Cardiomyocyte apoptosis and cardiac fibrosis are the leading causes of mortality in patients with ischemic heart disease. As such, these processes represent potential therapeutic targets to treat heart failure resulting from ischemic insult. We previously demonstrated that the mitochondrial acetyltransferase protein GCN5L1 regulates cardiomyocyte cytoprotective signaling in ischemia-reperfusion injury in vivo and hypoxia-reoxygenation injury in vitro. The current study investigated the mechanism underlying GCN… Show more
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