GC-ToF-MS based phytochemical analysis and anti-mycotoxigenic activity of South African medicinal plants, Mystroxylon aethiopicum (Thunb.) Loes. and Spirostachys africana Sond.

Molele, P.K.; Makhafola, Tshepiso Jan; Mongalo, N.I.

doi:10.1016/j.sajb.2022.12.007

Cited by 1 publication

(1 citation statement)

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“…C. caffrum exhibited an MIC value of 0.31 mg/mL against two Furasium strains such as F. vercitilloides and F. graminearum . According to reports, the extracts with a similar MIC at two different temperatures might mean that the extracts are fungistatic and, if used in a ploughing field to encounter mycotoxin infection, should be administered frequently until the fungal strains die off [ 43 , 44 ]. F. verticilloides mainly infect maize and are notoriously known to produce harmful secondary metabolites known as fumosinin mycotoxin which causes severe human and animal diseases [ 45 , 46 ].…”

Section: Discussionmentioning

confidence: 99%

GC-ToF-MS Profiling and In Vitro Inhibitory Effects of Selected South African Plants against Important Mycotoxigenic Phytopathogens

Mariri,

Dikhoba,

Mongalo

et al. 2023

Life

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The harmful effects following the ingestion of mycotoxin-contaminated food include the induction of cancers, mutagenicity, immune suppression, and toxicities that target organs of the digestive, cardiovascular, and central nervous systems. Synthetic fungicides are generally associated with a high toxic residue in food and the development of excessive fungal resistance. This study aimed to determine the antifungal activities against mycotoxigenic fungi of selected South African plant leaves and potentially develop plant-derived bio-fungicides, and, furthermore, to explore the in vitro antioxidant activity and the phytochemical spectra of the compounds of the selected medicinal plant extracts. The extracts were tested for antifungal activity against phytopathogenic strains using a microdilution broth assay. Bauhinia galpinii extracts exhibited the lowest minimum inhibitory concentration (MIC) against C. cladospoides and P. haloterans at 24 h incubation periods. C. caffrum had good antioxidant activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) with 50% inhibitory concentration (IC50) values of 0.013 mg/mL while B. galpini had IC50 values of 0.053 against free radicals of 2,2′-azinobis (3-ethylbenzthiazoline-6-suphonic acid (ABTS). The antimycotoxigenic and antioxidant activity exerted by both B. galpinii and C. caffrum may well be attributed to high TPC. In the GC-ToF-MS analysis, all the selected medicinal plants exhibited the presence of Hexadecanoic acid at varying % areas, while both B. galpinii and C. caffum exhibited the presence of lupeol at % area 2.99 and 3.96, respectively. The compounds identified, particularly the ones with higher % area, may well explain the biological activity observed. Although the selected medicinal plants exhibited a notable biological activity, there is a need to explore the safety profiles of these plants, both in vitro and in vivo.

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