GC-MS-FID characterization and antibacterial activity of the Mikania cordifolia essential oil and limonene against MDR strains

Araújo, Ana Carolina Justino de; Freitas, Priscilla Ramos; Barbosa, Cristina Rodrigues dos Santos; Muniz, Débora Feitosa; Rocha, Janaína Esmeraldo; Silva, Ana Cristina Albuquerque da; Oliveira-Tintino, Cícera Datiane de Morais; Ribeiro-Filho, Jaime; Silva, Luiz Everson da; Confortin, Camila; Amaral, Wanderlei do; Deschamps, Cícero; Barbosa-Filho, José Maria; Lima, Natanael Teles Ramos de; Tintino, Saulo Relison; Coutinho, Henrique Douglas Melo

doi:10.1016/j.fct.2019.111023

Cited by 23 publications

(13 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The growth of foodborne strains Listeria sp., Salmonella sp., Vibrio sp., Shigella sp. was inhibited by a variety of NPs-CAAs, including essential oils such as thymol and nerolidol [85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 31, 95, 96, 27, 97, 98, 48, 40, 99, 100, 101, 102, 103, 104, 105, 106, 107, 70, 108, 86].…”

Section: Resultsmentioning

confidence: 99%

Perspectives on the enhancement of commercially available antibiotics by natural products

Nitsch-Velasquez

Segura²,

Barrios

et al. 2022

Preprint

View full text Add to dashboard Cite

Background: Opportunistic resistant bacteria are health and economically relevant in the health care systems and in industries worldwide, especially in the so-called resistant bacteria era (RBE). Enhancing the activity of commercially available antibiotics (CAAs) with di erent types of natural products (NPs) is a successful antimicrobial strategy, for instance the amoxicillin and clavulanate mixture. Objective: To nd research trends in this eld during 2015-2020 and to detect potential drug hits with potential to diversify formulations and materials design that can be useful to manage the RBE. Systematic review results: It yielded 190 reports of synergistic e ects of CAAs and NPs. The analyzed variables were: a) natural products origin: plant family, genera, secondary metabolite type; b) strains: +/- Gram, genera, most frequent species, application eld; and c) CAAs: family, most frequent CAAs. The families with potential to have more bioactive species were Apocynaceae, Rubiaceae, Euphorbiaceae (Isbio factor). Lonicera had the highest reports amount. Polyphenols and avonoids were the majority of pure NPs tested. Several potential drug hits for antibiotic activity enhancement at synergistic level were identi ed together with potential mechanisms of action: berberine (drug e ux inhibitor{DEI, bio lm inhibitor{BI), curcumin (BI), essential oils (BI), 3-o-metyl-butylgallato (inhibition of fatty acid saturation), among others. About the half of the tested strains were gram positive, being Methicillin Resistant Staphylococcus aureus (MRSA) the most frequently tested. Escherichia coli was the gram negative strain most frequently reported, including enterotoxigenic and extended spectrum beta-lactamases producers. The growth of other foodborne genera strains, such as Listeria and Salmonella, were also inhibited. Aminoglycosides were the family most reported, with gentamicin as the most commonly studied. Conclusions: NPs as either as plant extracts from a variety of families, or as puri ed compounds specially avonoids and polyphenols, have shown e ective results to enhance the antibiotic activity of CAAs against gram positive and negative strains relevant to HC and FI. Their mechanisms of action are starting to be determined, as the case EPIs and BIs. Further research is needed to achieve co-formulations and materials design useful for those elds, that can certainly be positively impacted by pursuing this strategy.

show abstract

Section: Resultsmentioning

confidence: 99%

Perspectives on the enhancement of commercially available antibiotics by natural products

Nitsch-Velasquez

Segura²,

Barrios

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Although the essential oil of Mikania cordifolia (EOMc) and its major constituent, limonene, has no direct antibacterial activity, it can reverse antibiotic resistance by regulating the action of antibiotics. For P. aeruginosa , EOMc combined with gentamicin and norfloxacin displayed a synergistic antibacterial effect; and for S. aureus , EOMc reduced the MIC of gentamicin toward bacteria ( Justino de Araújo et al, 2020 ).…”

Section: Strategies To Reverse Bacterial Resistance To Aminoglycoside...mentioning

confidence: 99%

Antibiotic Combination Therapy: A Strategy to Overcome Bacterial Resistance to Aminoglycoside Antibiotics

et al. 2022

View full text Add to dashboard Cite

After the first aminoglycoside antibiotic streptomycin being applied in clinical practice in the mid-1940s, aminoglycoside antibiotics (AGAs) are widely used to treat clinical bacterial infections and bacterial resistance to AGAs is increasing. The bacterial resistance to AGAs is owed to aminoglycoside modifying enzyme modification, active efflux pump gene overexpression and 16S rRNA ribosomal subunit methylation, leading to modification of AGAs’ structures and decreased concentration of drugs within bacteria. As AGAs’s side effects and bacterial resistance, the development of AGAs is time-consuming and difficult. Because bacterial resistance may occur in a short time after application in clinical practice, it was found that the antibacterial effect of the combination was not only better than that of AGAs alone but also reduce the dosage of antibiotics, thereby reducing the occurrence of side effects. This article reviews the clinical use of AGAs, the antibacterial mechanisms, the molecular mechanisms of bacterial resistance, and especially focuses a recent development of the combination of AGAs with other drugs to exert a synergistic antibacterial effect to provide a new strategy to overcome bacterial resistance to AGAs.

show abstract

“…In fact, Ünal et al demonstrated the broad-spectrum and dose-dependent antifungal effect of limonene, showing higher effectiveness than standard product Fungizone ® at even lower doses (10 µL) [41]. Even more, limonene can modulate the antimicrobial effect of commonly used antibiotics against certain strains [42]. As an example, the combination of limonene and gentamicin considerably reduced the minimum inhibitory concentration (MIC) versus both Gram-positive and Gram-negative clinical bacteria, reaching values of 13.7-4 µg/mL against S. aureus and 30-20.1 µg/mL, against E. coli, respectively [43].…”

Section: Prevention and Inhibition Of Pest Attack In Crops And Food-spoilage Microorganismsmentioning

confidence: 99%

Encapsulated Limonene: A Pleasant Lemon-Like Aroma with Promising Application in the Agri-Food Industry. A Review

2020

View full text Add to dashboard Cite

Limonene, mainly found as a major component in Citrus spp., has been proven to possess a valuable potential as sustainable replacement to synthetic pesticides and food preservatives. This review intends to give a clear overview of the principal emerging applications of limonene in the agri-food industry as antimicrobial, herbicidal and antioxidant agent. To successfully use limonene in a greener agri-food industry, its preservation had become a top concern for manufacturers. In order to elucidate the most efficient and sustainable manner to encapsulate limonene, the different techniques and materials tested up to the present are also reviewed. In general, encapsulation conserves and protects limonene from outside aggressions, but also allows its controlled release as well as enhances its low water solubility, which can be critical for the discussed applications. Other parameters such as scalability, low cost and availability of equipment will need to be taken into account. Further efforts would likely be oriented to the elucidation of encapsulating sustainable systems obtained by cost-efficient elaboration processes, which can deliver effective concentrations of limonene without affecting crops and food products.

show abstract

GC-MS-FID characterization and antibacterial activity of the Mikania cordifolia essential oil and limonene against MDR strains

Cited by 23 publications

References 31 publications

Perspectives on the enhancement of commercially available antibiotics by natural products

Perspectives on the enhancement of commercially available antibiotics by natural products

Antibiotic Combination Therapy: A Strategy to Overcome Bacterial Resistance to Aminoglycoside Antibiotics

Encapsulated Limonene: A Pleasant Lemon-Like Aroma with Promising Application in the Agri-Food Industry. A Review

Contact Info

Product

Resources

About