GC–MS determination of phthalate esters in human urine: A potential biomarker for phthalate bio-monitoring

Ramaswamy, Babu Rajendran; Preethi, Gopalakrishnan; Poopal, Rama Krishnan; Nikhil, Nishikant Patil; Vimalkumar, Krishnamoorthi; Subramanian, Annamalai; Krishna-Kumar, Selvaraj

doi:10.1016/j.jchromb.2018.01.039

Cited by 23 publications

(7 citation statements)

References 56 publications

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“…In our study, the different kinds of free fatty acids were isolated and analyzed by GC-MS (11), which is a method that combines the characteristics of gas chromatography and mass spectrometry to identify different substances in a blood or urine sample when used in medical research (12,13). Diseases such as systemic lupus erythematosus (6), search for metabolic markers in this way.…”

Section: Discussionmentioning

confidence: 99%

Abnormalities of Serum Fatty Acids in Children With Henoch–Schönlein Purpura by GC-MS Analysis

et al. 2021

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Purpose: The objectives of this work were to test the levels of serum medium- and long- chain fatty acids (MLCFAs) in children and to discover their possible relationship with Henoch-Schönlein Purpura (HSP), also known as Immunoglobulin A vasculitis.Methods: A total of 57 children with HSP (HSP group) and 28 healthy children (CON group) were recruited for this study. Serum specimens were collected to detect the compositions and contents of MLCFAs by gas chromatography with mass spectrometry (GC-MS) analysis.Results: The contents of all detected 37 MLCFAs in the HSP group were higher than the healthy group. Thirty-one species of MLCFAs were discovered to have a significant difference (p < 0.05) in two groups. Comparing to healthy controls, there were 31, 31, 18 fatty acids showed a statistical difference in the untreated group, regular treated group, and withdrawal group of HSP, respectively. The trend of fatty acids in the three HSP groups was similar to the healthy controls, as well as the untreated group and regular treated group changed more obviously than the withdrawal group. Almitate (C16:0) and 18 carbon atoms (C18) of fatty acids were abundant in all three HSP groups, divided according to the treatment of glucocorticoid. Some fatty acids were found having considerable differences (p < 0.05) in three groups. Monounsaturated fatty acids (MUFAs), including elaidate (C18:1T), cis-11,14,17-eicosatrienoic acid ester (C20:1), and cis-15-tetracosenoate (C24:1), were distinctly higher in HSP children with renal damage.Conclusion: Our study revealed that the abnormalities in MLCFA may be associated with the development of HSP. Another interesting finding was that fatty acids contents were changing during the glucocorticoid treatment. Meanwhile, long-chain MUFAs may have an impact on renal damage in HSP patients. Further studies need to be carried out in order to explore the specific mechanism of fatty acids in the course of HSP.

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Section: Discussionmentioning

confidence: 99%

Abnormalities of Serum Fatty Acids in Children With Henoch–Schönlein Purpura by GC-MS Analysis

et al. 2021

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“…GC-MS is a method that combines the characteristics of gas chromatography and mass spectrometry to identify different substances almost in a blood or urine sample when used in medical research [6,7]. Diseases such as systemic lupus erythematosus [8], look for metabolic markers in this way.…”

Section: Discussionmentioning

confidence: 99%

Role of Serum Fatty Acids in Children with Henoch-Schönlein purpura by GC-MS analysis

Wen

Feng

Dang

et al. 2020

Preprint

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BACKGROUND: The objectives of this work were to discover the changes of serum Medium- and Long-Chain fatty acids levels and its possible relationship with Henoch-Schönlein Purpura (HSP), also referred to as Immunoglobulin A vasculitis in children. METHODS: A total of 58 children with HSP and 28 healthy children were recruited for this study. Serum fatty acids were analyzed by gas chromatography with mass spectrometry (GC-MS). RESULTS: 31 species of Fatty acids were discovered to have a significant difference between HSP group and healthy control group (CON group). The contents of all detected 37 fatty acids in the HSP group were higher than the healthy group. Parts of fatty acids were found in our study having significant change according to the treatment. Palmitate (C16:0) and 18 carbon atoms (C18) of fatty acids were abundant in all three groups of HSP. Elaidate (C18:1T), cis-11,14,17-Eicosatrienoic acid ester (C20:1) and cis-15-tetracosenoate (C24:1) were found to have a correlation on renal damage of HSP. CONCLUSION: Our study provides clinical evidence to support that fatty acid metabolism is associated with HSP by GC-MS method. Glucocorticoid therapy has a certain relationship with fatty acid metabolism during HSP treatment. Meanwhile, long-chain MUFAs may have an impact on renal damage of HSP. In addition, we speculate that a low BMI may be a kind of manifestation of abnormal fatty acid metabolism in HSP. All in all, further study is needed to explore the specific mechanism of fatty acids and HSP.

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“…In contrast, data on a large set of extensively used EDCs including BPA, phthalates, polybrominated diphenyl ethers (PBDEs), PFASs, etc. are scarce or missing (Xue et al 2015 ; Yadav et al 2015 ; Shekhar et al 2017 ; Pednekar et al 2018 ; Toxics Link 2018a , b ; Babu-Rajendran et al 2018 ; Ruan et al 2019 ; Malik et al 2021 ; Mukherjee Das et al 2022 ). In this direction, unlike in many developed countries where EDC human biomonitoring programs are well-established, the role of public health institutions has not been essentially explored in monitoring EDCs and their health consequences for the general Indian population.…”

Section: Challenges For Managing Edcs In Indiamentioning

confidence: 99%

Unlocking India’s Potential in Managing Endocrine-Disrupting Chemicals (EDCs): Importance, Challenges, and Opportunities

et al. 2022

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Endocrine-disrupting chemicals (EDCs) are a prime concern for the environment and health globally. Research shows that in developing countries such as India both the environment and human populations are severely exposed to EDCs and consequently experience rising incidents of adverse health effects such as diabetes and cancers. In this paper, we discuss the current EDC management approach in India, critically assess its limitations, and describe opportunities for potential improvements. Foremost, current EDC management actions and interventions in India are fragmented and outdated, and far behind the modern and comprehensive approaches adopted in the European Union and other developed countries. Strong and well-planned actions are required on various fronts of science, policy, commerce, and public engagement. These actions include the adoption of a dedicated and modern regulatory framework for managing EDCs, enhancing capacity and infrastructure for EDC monitoring in the environment and human population, employing public–private partnership programs for not only managing EDCs but also in the sectors that indirectly contribute toward the mismanagement of EDCs in the country, and raising awareness on EDCs and promoting health-preserving consumption habits among the public. As India hosts a large proportion of the global human population and biodiversity, the success or failure of its actions will substantially affect the direction of global efforts to manage EDCs and set an example for other developing countries.

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GC–MS determination of phthalate esters in human urine: A potential biomarker for phthalate bio-monitoring

Cited by 23 publications

References 56 publications

Abnormalities of Serum Fatty Acids in Children With Henoch–Schönlein Purpura by GC-MS Analysis

Abnormalities of Serum Fatty Acids in Children With Henoch–Schönlein Purpura by GC-MS Analysis

Role of Serum Fatty Acids in Children with Henoch-Schönlein purpura by GC-MS analysis

Unlocking India’s Potential in Managing Endocrine-Disrupting Chemicals (EDCs): Importance, Challenges, and Opportunities

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