GC-MS and LC-MS analyses reveal the distribution of primary and secondary metabolites in mangosteen (Garcinia mangostana Linn.) fruit during ripening

Mamat, Siti Farah; Azizan, Kamalrul Azlan; Baharum, Syarul Nataqain; Noor, Normah Mohd; Aizat, Wan Mohd

doi:10.1016/j.scienta.2019.109004

Cited by 43 publications

(24 citation statements)

References 73 publications

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“…Likewise, mangiferin, a xanthone derivative was analysed and quantified in Swertia chirayita methanolic extract using LC-ESI/MS in positive mode 17 . In contrast, there are a number of studies that analysed and quantified prenylated xanthones in G. mangostana in negative ionisation mode MS 4 , 18 . To obtain structural information, MS/MS studies of the molecular ion of each compound were performed.…”

Section: Resultsmentioning

confidence: 99%

LC-QTOF-MS analysis of xanthone content in different parts of Garcinia mangostana and its influence on cholinesterase inhibition

Khaw

Chong

Murugaiyah

2020

Journal of Enzyme Inhibition and Medicinal Chemistry

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Mangosteen is one of the best tasting tropical fruit widely cultivated in Southeast Asia. This study aimed to quantify xanthone content in different parts of Garcinia mangostana by LC-QTOF-MS and determine its influence on their cholinesterase inhibitory activities. The total xanthone content in G. mangostana was in the following order: pericarp > calyx > bark > stalk > stem > leaves > aril. The total xanthone content of pericarp was 100 times higher than the aril. Methanol extracts of the pericarp and calyx demonstrated the most potent inhibitory activities against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with IC 50 values of 0.90 and 0.37 mg/mL, respectively. Statistical analysis showed a strong correlation between xanthone content and cholinesterase inhibition. Nonmetric multidimensional scaling analysis revealed a-mangostin and c-mangostin of pericarp as the key metabolites contributing to cholinesterase inhibition. Due to the increasing demand of mangosteen products, repurposing of fruit waste (pericarp) has great potential for enhancement of the cognitive health of human beings.

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Section: Resultsmentioning

confidence: 99%

LC-QTOF-MS analysis of xanthone content in different parts of Garcinia mangostana and its influence on cholinesterase inhibition

Khaw

Chong

Murugaiyah

2020

Journal of Enzyme Inhibition and Medicinal Chemistry

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“…They found differential accumulation patterns of both flavonoids and amino acids in various tissues and species [ 13 ]. Although metabolomics-based methods have been applied in fruits [ 13 , 29 , 34 , 35 , 36 ], comparative analyses of nutritional metabolites in distinct fruits are rarely conducted. In this study, we detected more than 20,000 metabolic signals with the non-targeted LC-MS method.…”

Section: Discussionmentioning

confidence: 99%

Cross-Species Comparison of Metabolomics to Decipher the Metabolic Diversity in Ten Fruits

Shi

et al. 2021

Metabolites

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Fruits provide humans with multiple kinds of nutrients and protect humans against worldwide nutritional deficiency. Therefore, it is essential to understand the nutrient composition of various fruits in depth. In this study, we performed LC-MS-based non-targeted metabolomic analyses with ten kinds of fruit, including passion fruit, mango, starfruit, mangosteen, guava, mandarin orange, grape, apple, blueberry, and strawberry. In total, we detected over 2500 compounds and identified more than 300 nutrients. Although the ten fruits shared 909 common-detected compounds, each species accumulated a variety of species-specific metabolites. Additionally, metabolic profiling analyses revealed a constant variation in each metabolite’s content across the ten fruits. Moreover, we constructed a neighbor-joining tree using metabolomic data, which resembles the single-copy protein-based phylogenetic tree. This indicates that metabolome data could reflect the genetic relationship between different species. In conclusion, our work enriches knowledge on the metabolomics of fruits, and provides metabolic evidence for the genetic relationships among these fruits.

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“…However, the most commonly used in food analysis are NMR and MS. The combination of these techniques is widely used, the detection is coupled to the separation equipment, resulting in GC–MS, LC–MS, UPLC–MS, and HPLC–UV [ 24 , 42 , 59 , 60 , 61 , 62 , 63 ].…”

Section: Platforms For Metabolomic Studies: Analytical Methods and Data Processingmentioning

confidence: 99%

“…The combination involving chromatographic techniques (detection) and mass spectrometry (separation) contemplates an effective tool for the analysis of complex matrices as is the case of foods, characterizing the structure and mass of molecules in a robust and precise manner [ 65 ]. Mamat et al [ 61 ] gathered the GC–MS and LC–MS techniques to evaluate the metabolic profile (primary and secondary metabolites) in mangosteen ( Garcinia mangostana Linn.) at different times of ripening.…”

Section: Platforms For Metabolomic Studies: Analytical Methods and Data Processingmentioning

confidence: 99%

Food Metabolites as Tools for Authentication, Processing, and Nutritive Value Assessment

Pedrosa

Lima

Heleno

et al. 2021

Foods

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Secondary metabolites are molecules with unlimited applications that have been gaining importance in various industries and studied from many angles. They are mainly used for their bioactive capabilities, but due to the improvement of sensibility in analytical chemistry, they are also used for authentication and as a quality control parameter for foods, further allowing to help avoid food adulteration and food fraud, as well as helping understand the nutritional value of foods. This manuscript covers the examples of secondary metabolites that have been used as qualitative and authentication molecules in foods, from production, through processing and along their shelf-life. Furthermore, perspectives of analytical chemistry and their contribution to metabolite detection and general perspectives of metabolomics are also discussed.

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GC-MS and LC-MS analyses reveal the distribution of primary and secondary metabolites in mangosteen (Garcinia mangostana Linn.) fruit during ripening

Cited by 43 publications

References 73 publications

LC-QTOF-MS analysis of xanthone content in different parts of Garcinia mangostana and its influence on cholinesterase inhibition

LC-QTOF-MS analysis of xanthone content in different parts of Garcinia mangostana and its influence on cholinesterase inhibition

Cross-Species Comparison of Metabolomics to Decipher the Metabolic Diversity in Ten Fruits

Food Metabolites as Tools for Authentication, Processing, and Nutritive Value Assessment

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