GC-MS Analysis of Chemical Constituents of Hydroalcoholic Leaf Extract of Cissampelos Pareira and Their Anti-Diabetic Activity

Asif, Mohammad; Gilani, Sadaf Jamal; Taleuzzaman, Mohamad; Kala, Chandra; Godara, Deepak; Rahat, Iqra; Khan, Najam Ali

doi:10.9734/aprj/2021/v7i130148

Cited by 2 publications

(2 citation statements)

References 19 publications

(26 reference statements)

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“…The GC-MS analysis of the optimal pigeon pea seed extract revealed 13.85 % of the isoflavone components. In addition to isoflavone, the extract contains mome inositol, which possesses anti-alopecic, anti-cirrhotic, lipotropic, chloesterolytic, anti-neuropathic, and anti-diabetic characteristics 23,24 . Other antioxidant substances as Hexadecanoic Acid by 7.6% and phenol compounds by 1.8%.…”

Section: Identification Of Bioactive Compoundsmentioning

confidence: 99%

Ultrasonic - Assisted Extraction and Microencapsulation of Bioactive Compound From Pigeon Pea Seed

Irsal¹,

Yusuf²,

Hayah³

et al. 2023

Bulletin of Pharmaceutical Sciences. Assiut

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The global COVID-19 pandemic that began at the end of 2019 has not finished until now. So it is necessary to use local food that contains antioxidant compounds that can improve the immune system. Pigeon pea is one of the indigenous foods that can be utilized as a functional food because it contains bioactive compounds-the objective of this work is to obtain the optimal condition for extracting pigeon pea seed based on total phenol content (TPC) and antioxidant activity and then microencapsulation it. It was demonstrated that the best extraction conditions were 30 min, a temperature of 60 °C, and 90% methanol with TPC 36.0219 mg GAE/30 g dry sample and antioxidant activity 19.6091 mg AAE/30 g dry sample. Pigeon pea seed extract was entrapped by Freeze-drying using gum arabic and maltodextrin as wall material. Microcapsules contained 8.85% water with a solubility of 87.35%. Microcapsules have a color of greenish-yellow chromaticity (GY) and irregular shape with an average size of 23.03 μm. The best bioactive compounds in pigeon pea seed extract showed the most compounds: mome inositol (42,76%) and isoflavones (13,85%). In addition, there are several other compounds showing bioactivity as antioxidants.

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Section: Identification Of Bioactive Compoundsmentioning

confidence: 99%

Ultrasonic - Assisted Extraction and Microencapsulation of Bioactive Compound From Pigeon Pea Seed

Irsal¹,

Yusuf²,

Hayah³

et al. 2023

Bulletin of Pharmaceutical Sciences. Assiut

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“…100 mg/kg, b.w was chosen as low dose, and double of medium-dose i.e. 400 mg/kg, b.w was selected as high dose [12].…”

Section: Experimental Groupsmentioning

confidence: 99%

Evaluation of Anti-depressant, Anti-anxiety and Muscle Relaxant Activity of Hydroalcoholic Extract of Aerva javanica Roots

Waqas¹,

Sharma²,

Yadav³

et al. 2021

JOCAMR

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Aims: To evaluate anti-depressant, anti-anxiety and muscle relaxant activity of hydroalcoholic extract of Aerva javanica roots in various experimental animal models. Study Design: Animal study. Place and Duration of Study: The study was conducted in Bilwal Medchem and Research Laboratory, Jaipur from July 2021-August 2021. Methodology: The root powder of Aerva javanica was extracted with hydroalcoholic solvent (70% ethanol). The hydroalcoholic extract at three doses 100 mg/kg, 200 mg/kg, and 400 mg/kg was checked for anti-depressant and skeletal muscle relaxant activity in the experimental animal models. To determine the anti-depressant activity tail suspension test, locomotor activity, open field test, and MAO inhibitor assay were done; to determine the anti-anxiety activity hole board test was used; and to determine the skeletal muscle relaxant activity rotarod test, grip strength test, and chimney test were done. Results: In the tail suspension test, the extract at 200 mg/kg and 400 mg/kg significantly reduced the duration of immobility compared to normal control (p<0.0001). The extract at dose 400 mg/kg significantly reduced MAO-A and MAO-B activity compared to the normal control group (p<0.01 and p<0.05, respectively). The extract at 200 mg/kg and 400 mg/kg were able to decrease locomotor activity in actophotomoter and increased time spent in centre square in open field test revealing the sedative effect of the extract. In hole board test, the extract at dose 400 mg/kg and 200 mg/kg significantly increased number of head dip count (p<0.0001 and p<0.001) respectively. In the rotarod test, the extract at dose 200 and 400 mg/kg decreased the time spent on the rotating rod (p<0.0001), compared to normal control. Similarly, in the grip strength test the extract at dose 200 and 400 mg/kg decreased the time spend on suspended wire revealing the skeletal muscle relaxant property of the test extract. Conclusion: Based on the result, it can be concluded that the extract exert anti-depressant, anti-anxiety and skeletal muscle relaxant like activity in the experimental rat which was hypothesized to be attributed to the flavonoids present in the hydroalcoholic root extract of Aerva javanica.

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GC-MS Analysis of Chemical Constituents of Hydroalcoholic Leaf Extract of Cissampelos Pareira and Their Anti-Diabetic Activity

Cited by 2 publications

References 19 publications

Ultrasonic - Assisted Extraction and Microencapsulation of Bioactive Compound From Pigeon Pea Seed

Ultrasonic - Assisted Extraction and Microencapsulation of Bioactive Compound From Pigeon Pea Seed

Evaluation of Anti-depressant, Anti-anxiety and Muscle Relaxant Activity of Hydroalcoholic Extract of Aerva javanica Roots

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