GC-MS analysis, evaluation of phytochemicals, anti-oxidant, thrombolytic and anti-inflammatory activities of &lt;i&gt;Exacum bicolor&lt;/i&gt;

Ashwini, A.; Puttarudrappa, Latha; Ravi, B V; Majumdar, Mala

doi:10.3329/bjp.v10i4.23610

Cited by 5 publications

(3 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is in agreement with a previous finding that inhibition of platelet aggregation prolongs the bleeding time (Gadi et al, 2009) as well as in accordance with the findings of De Caterina et al (1994) who had proposed an inverse relationship between platelet number and bleeding time. Like B. calliobotrys, Exacum bicolor shows thrombolytic activity (Ashwini et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Antithrombotic potential of <i>Berberis calliobotrys</i> extract

Alamgeer

Asif

Rasool

2016

Bangladesh J Pharmacol

View full text Add to dashboard Cite

This study was focused with the aim to investigate the antithrombotic potential of Berberis calliobotrys. Aqueous-methanolic extract and various fractions showed significant (p<0.05-0.001) increase in prothrombin, activated partial thromboplastin and clotting time while only aqueous methanolic extract caused clot lysis when added to the blood samples of rabbit and human. In vivo study in rabbits, butanolic fraction (100 mg/kg) produced more significant prolongation in bleeding, prothrombin, activated partial thromboplastin and clotting time. Interestingly butanolic fraction had shown more pronounced effects among all tested extracts both in vivo and in vitro studies. Hence, it was subjected to antilipid peroxidation and phytochemical studies (total falvonoid contents, HPLC-DAD profile, FTIR). In conclusion, B. calliobotrys induce transient changes in the coagulation parameters, may it possess active constituents responsible for its antithrombotic potential. Article Info

show abstract

Section: Discussionmentioning

confidence: 99%

Antithrombotic potential of <i>Berberis calliobotrys</i> extract

Alamgeer

Asif

Rasool

2016

Bangladesh J Pharmacol

View full text Add to dashboard Cite

show abstract

“…Compared with the model group, each treatment group could significantly thickened cortex of thymus and a significant increase in the number of lymphocytes in the cortex (p<0.01), in which the effect of large dose of Curculigo rhizome total glycoside group is the best (Ashwini et al, 2015;Li et al, 2015) …”

Section: Thymus Tissue Morphologymentioning

confidence: 99%

Effects of Curculigo orchioides total glucosides in mouse perimenopause model of related organization and organs morphology

Cao

Tian

Bai

et al. 2016

Bangladesh J Pharmacol

View full text Add to dashboard Cite

The purpose of this study was to examine the effects of Curculigo orchioides total glucosides in mouse perimenopause model. The castrated mice were treated with different doses of soybean isoflavone soft capsule, Gengnian'an, C. rhizome total glycoside. Hypothalamus, thymus, spleen and uterus were collected and then fixed in 10% formaldehyde, HE staining, to observe the pathological changes of morphology. The results indicate that compared with the model group, soybean isoflavone soft capsule, gengnianan capsule and big, medium, small dose of C. rhizome total glycoside group could significantly improved the pathological changes in mouse uterus, hypothalamic, thickening of the thymic cortex and significantly increased the number of lymphocytes in the cortex, increased the volume of splenic nodule (p<0.01), in which the effect of large dose of C. orchioides total glycosides group was the best. In conclusion, C. orchioides total glucosides in mice caused by perimenopausal pathological changes of uterine, hypothalamus, spleen and other organs have good improvement effect.

show abstract

“…anti-oxidant, thrombolytic and anti-inflammatory agent (Ashwini et al, 2015). It contains various phytochemicals such as phenols, saponins, flavonoids and alkaloids.…”

mentioning

confidence: 99%

A Study on Correlation and Association of Characters of Exacum Tetragonum Roxb. In North Kerala, India

Radhakrishnan¹,

Mohanan²

2021

IJAR

View full text Add to dashboard Cite

Western Ghats provide asylum to several endemic plants. Exacum tetragonum Roxb. is one of the important endemic herbs inhabiting the hilly tracts and midlands of Kerala, the state of India located towards the south-western side of the Western Ghats. The plant is used for treating fever, stomach disorders, gout, diabetics, and eye diseases. It is also found associated with antioxidant, anti-inflammatory, anti-helminthic and anti-hyperglycemic activities. Correlation and association of characters of this important medicinal plant was analyzed based on the observations on thirteen salient morphological characters recorded from twenty three populations of the species distributed across Malappuram, Thrissur, Kozhikode and Palakkad Districts of Kerala State of India. All the characters studied such as plant height, number of leaves, number of flowers, number of inflorescences, leaf length, leaf breadth, peduncle length, pedicel length, internodal length, leaf area, mean stem girth, number of branches and fresh weight of plants showed statistically significant variations between the populations. Number of flowers showed significant positive correlation with the maximum number of characters (ten characters) whereas number of leaves showed significant positive correlation with the minimum number of characters (two characters). By factor analysis, two factors could be extracted and fresh weight of plant was found to be the lead character. Significant variability with regard to morphological characters indicates the strong genetic base of the plant species in the field. However, drastic changes in its habitat for various reasons can certainly cause severe threats to its continued existence and hence appropriate actions to conserve the natural habitats of this species are vital.

show abstract

GC-MS analysis, evaluation of phytochemicals, anti-oxidant, thrombolytic and anti-inflammatory activities of <i>Exacum bicolor</i>

Cited by 5 publications

References 31 publications

Antithrombotic potential of <i>Berberis calliobotrys</i> extract

Antithrombotic potential of <i>Berberis calliobotrys</i> extract

Effects of Curculigo orchioides total glucosides in mouse perimenopause model of related organization and organs morphology

A Study on Correlation and Association of Characters of Exacum Tetragonum Roxb. In North Kerala, India

Contact Info

Product

Resources

About