GB virus C in systemic medium- and small-vessel necrotizing vasculitides

Servant, Annabelle

doi:10.1093/rheumatology/37.12.1292

Cited by 15 publications

(9 citation statements)

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“…[3][4][5] HCV positivity has occasionally been observed in patients with PAN, but it is not considered to be a major etiological factor; and is often observed concomitantly with other viral infections like HBV. [6][7][8] …”

Section: Polyarteritis Nodosa (Pan)mentioning

confidence: 99%

Hepatotropic Viral Infection Associated Systemic Vasculitides—Hepatitis B Virus Associated Polyarteritis Nodosa and Hepatitis C Virus Associated Cryoglobulinemic Vasculitis

Sharma

2013

Journal of Clinical and Experimental Hepatology

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Two hepatotropic viruses have been shown to have causal relationship with systemic vasculitis-hepatitis B with classical polyarteritis nodosa and hepatitis C with cryoglobulinemic vasculitis. The present paper provides an updated overview on the clinical presentations and management of these vasculitides.HBV associated PAN patients have higher weight loss, peripheral neuropathy, mononeuritis multiplex, abdominal pain, gastrointestinal manifestations requiring surgery, cardiomyopathy, orchitis, hypertension, and/or elevated transaminase levels. Microaneurysms are also more common in mesenteric artery. Skin manifestations, however are less common. These patients also have a severe disease as suggested by higher five factor score and higher BVAS. Though relapses are less common, mortality is higher in patients with HBV PAN as compared to non HBV PAN. Plasmapheresis has a role in treatment in clearing off immune complexes.The common clinical manifestations of HCV associated cryoglobulinemic vasculitis are skin lesions, peripheral neuropathy, glomerulonephritis, arthritis, and sicca symptoms. Though combination therapy comprising of pegylated interferon a and ribavirin is the first line of management, immunotherapy is needed for severe or life threatening manifestations. Recent randomized trials have shown the efficacy of rituximab in such situations. ( J CLIN EXP HEPATOL 2013;3:204-212)

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Section: Polyarteritis Nodosa (Pan)mentioning

confidence: 99%

Hepatotropic Viral Infection Associated Systemic Vasculitides—Hepatitis B Virus Associated Polyarteritis Nodosa and Hepatitis C Virus Associated Cryoglobulinemic Vasculitis

Sharma

2013

Journal of Clinical and Experimental Hepatology

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“…However, hepatitis G virus is unlikely to play a role in the vasculitides, since RNA is not usually found in the lesions of this type of patient. 2 The other similarities with PAN were: five out of 10 PAN 1990 classification criteria were fulfilled: myalgia, weight loss, skin vasculitides, arteriographic abnormalities and mononeuropathy. 3 The Chapel Hill 1992 consensus conference criteria for PAN (negative pANCA and no small-sized vessel infiltration) were also found, excluding the diagnosis of microscopic polyangiitis.…”

Section: Discussionmentioning

confidence: 99%

Polyvisceral arteritis in chronic graft-versus-host disease: antiphospholipid-negative thrombotic syndrome mimicking polyarteritis nodosa

Ysebaert

Deconinck

Larosa

et al. 2002

Bone Marrow Transplant

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“…HCV does not seem to be a major etiological factor for PAN despite some descriptions (Cacoub et al, 1992). GB virus-C, when sought in patients with PAN, has not been found to be an agent responsible for the disease (Servant et al, 1998). When present, HCV was often observed in association with other viruses.…”

Section: Polyarteritis Nodosamentioning

confidence: 97%

Virus‐induced Systemic Vasculitides: New Therapeutic Approaches

Guillevin

2004

Journal of Immunology Research

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The best therapeutic strategy in virus-induced vasculitides should take into account the etiology of the disease and be adapted to the pathogenesis. The combination of antiviral treatments and plasma exchanges has been proven effective in polyarteritis nodosa (PAN). In human immunodeficiency virus (HIV)-related vasculitis this strategy is also effective and does not jeopardize, like cytotoxic agents, the outcome of AIDS. In vasculitis related to HCV-associated cryoglobulinemia, plasma exchanges improve the outcome but the poor effectiveness of antiviral drugs is not able to favor, usually, a definite recovery of the patients and relapses are frequent.

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GB virus C in systemic medium- and small-vessel necrotizing vasculitides

Cited by 15 publications

References 0 publications

Hepatotropic Viral Infection Associated Systemic Vasculitides—Hepatitis B Virus Associated Polyarteritis Nodosa and Hepatitis C Virus Associated Cryoglobulinemic Vasculitis

Hepatotropic Viral Infection Associated Systemic Vasculitides—Hepatitis B Virus Associated Polyarteritis Nodosa and Hepatitis C Virus Associated Cryoglobulinemic Vasculitis

Polyvisceral arteritis in chronic graft-versus-host disease: antiphospholipid-negative thrombotic syndrome mimicking polyarteritis nodosa

Virus‐induced Systemic Vasculitides: New Therapeutic Approaches

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