GB virus C/hepatitis G virus infection among Japanese patients with chronic liver disease and blood donors

Orito, Etsuro; Mizokami, Masashi; Nakano, Tatsunori; Wu, Ron-Ron; Chen, Kun; Ohba, Ken‐ichi; Ueda, Ryuzo; Mukaide, Motokazu; Hikiji, Kazumasa; Matsumoto, Yoshihisa; Iino, Shiro

doi:10.1016/s0168-1702(96)01379-2

Cited by 61 publications

(33 citation statements)

References 4 publications

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“…Epidemiological investigations demonstrated that GBV-C/HGV RNA prevalence among blood donors ranges from 0.5-4% in the USA, Europe and Japan (Orito et al 1996, Gutierrez et al 1997, Nübling et al 1997, Blair et al 1998, Sauleda et al 1999) to 10-18.9% in some African countries (Casteling et al 1998, El-Zayadi et al 1999, Sathar et al 1999. In South America, it has also been reported at a varying range from 5.5% in Argentina (Oubiña et al 1999) to 14.6% in Bolivia (Konomi et al 1999).…”

Section: Discussionmentioning

confidence: 99%

Prevalence and genotypes of GB Virus C/Hepatitis G virus among blood donors in Central Brazil

Oliveira

Martins

Carneiro

et al. 2002

Mem. Inst. Oswaldo Cruz

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Section: Discussionmentioning

confidence: 99%

Prevalence and genotypes of GB Virus C/Hepatitis G virus among blood donors in Central Brazil

Oliveira

Martins

Carneiro

et al. 2002

Mem. Inst. Oswaldo Cruz

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“…On the other hand, it has also been reported that GBV-C/HGV infection does not induce significant liver damage; hence, the nature of GBV-C/HGV and its real pathogenic role remain controversial (2,3). GBV-C/HGV is not characterized by a great genome variability as great as that of HCV, but several studies have suggested the existence of three different genotypes (13,14,22,24). Recently, we reported the existence of a novel genotype of GBV-C/HGV in Southeast Asian countries and designated it genotype 4 (16,17).…”

Section: Discussionmentioning

confidence: 99%

Molecular Characteristic-Based Epidemiology of Hepatitis B, C, and E Viruses and GB Virus C/Hepatitis G Virus in Myanmar

Nakai

Win

et al. 2001

J Clin Microbiol

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We carried out a molecular characteristic-based epidemiological survey of various hepatitis viruses, including hepatitis B virus (HBV), hepatitis C virus (HCV), hepatitis E virus (HEV), and GB virus C (GBV-C)/hepatitis G virus (HGV), in Myanmar. The study population of 403 subjects consisted of 213 healthy individuals residing in the city of Yangon, Myanmar, and the surrounding suburbs and 190 liver disease patients (155 virus-related liver disease patients and 35 nonviral disease patients). The infection rates of the viruses among the 213 healthy subjects were as follows: 8% for HBV (16 patients), 2% for HCV (4 patients), and 8% for GBV-C/HGV (17 patients). In contrast, for 155 patients with acute hepatitis, chronic hepatitis, liver cirrhosis, or hepatocellular carcinoma, the infection rates were 30% for HBV (46 patients), 27% for HCV (41 patients), and 11% for GBV-C/HGV (17 patients). In the nonviral liver disease group of 35 patients with alcoholic liver disease, fatty liver, liver abscess, and biliary disease, the infection rates were 6% for HBV (2 patients), 20% for HCV (7 patients), and 26% for GBV-C/HGV (9 patients). The most common viral genotypes were type C of HBV (77%), type 3b of HCV (67%), and type 2 of GBV-C/HGV (67%). Moreover, testing for HEV among 371 subjects resulted in the detection of anti-HEV immunoglobulin G (IgG) in 117 patients (32%). The age prevalence of anti-HEV IgG was 3% for patients younger than 20 years and 30% or more for patients 20 years of age or older. Furthermore, a high prevalence of anti-HEV IgG (24%) was also found in swine living together with humans in Yangon. These results suggest that these hepatitis virus infections are widespread in Myanmar and have led to a high incidence of acute and chronic liver disease patients in the region.

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“…GBV-C/HGV RNA extracted from 200 l of serum by the proteinase K/phenol-chloroform method was reverse-transcribed with 20 pmol of each outer primer, 10 units of reverse transcriptase (ALV Reverse Transcriptase; Life Science, St. Petersberg, FL), and 2 units of Tth DNA polymerase (Toyobo, Osaka, Japan) in a reaction mixture with a final volume of 100 l. The reaction mixture was incubated at 37°C for 1 hr for reverse transcription. Orito et al [1996]. Nucleotide positions are numbered as for PNF2161 (GenBank/EMBL accession number U44402).…”

Section: Rna Extraction From Serum and Detection Of Gbv-c/hgv Rnamentioning

confidence: 99%

GBV-C/HGV infection in children with chronic hepatitis C

et al. 1999

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The role of GB virus-C/hepatitis G virus (GBV-C/HGV), a recently identified member of the Flaviviridae family, in children with liver disease is not well understood. The aims of this study were to evaluate the prevalence of GBV-C/HGV and to clarify its pathogenic role in young patients with chronic hepatitis C. Sixty-four Japanese children and adolescents with chronic hepatitis C virus (HCV) infection, with a mean age of 9.8 years, were evaluated retrospectively. Twenty-one (32.8%) of the 64 patients were positive for serum GBV-C/HGV RNA. Only 1 (1.6%) of the 64 patients was positive for antibody against the envelope protein E2 of GBV-C/HGV (anti-E2) and GBV-C/HGV. None of them was positive for anti-E2 alone. There was no significant difference in clinical, virological, or histological characteristics between GBV-C/HGV-positive and GBV-C/HGV-negative patients, except for underlying malignant disease. There was no evidence that GBV-C/HGV might affect the response of HCV to interferon therapy in young patients with chronic hepatitis C. The prevalence of GBV-C/HGV infection in young patients with chronic hepatitis C is similar to that in adult patients with chronic hepatitis C, but E2-seroconversion is observed infrequently. Underlying malignant disease is a risk factor for GBV-C/HGV viremia. GBV-C/HGV does not seem to affect the clinical course of young patients with chronic hepatitis C.

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GB virus C/hepatitis G virus infection among Japanese patients with chronic liver disease and blood donors

Cited by 61 publications

References 4 publications

Prevalence and genotypes of GB Virus C/Hepatitis G virus among blood donors in Central Brazil

Prevalence and genotypes of GB Virus C/Hepatitis G virus among blood donors in Central Brazil

Molecular Characteristic-Based Epidemiology of Hepatitis B, C, and E Viruses and GB Virus C/Hepatitis G Virus in Myanmar

GBV-C/HGV infection in children with chronic hepatitis C

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