GB virus C/hepatitis G virus infection in autoimmune liver diseases

Abstract

All the patients with AIH were female (mean age, 57.6 Ϯ 14.1 years).Tests for hepatitis B surface antigen (HBsAg) and anti-HCV antibody were negative in all PBC and AIH patients. Sera were stored at Ϫ80°C until tested.GBV-C/HGV was detected in one patient, a 59year-old woman, who had asymptomatic PBC and no history of blood transfusion. Pertinent laboratory values were: total bilirubin, 0.4 mg/dl; alanine aminotransferase (ALT),

Influence of RNA titre and amino acid changes in the NS5A region of GB virus C/hepatitis G virus on the effectiveness of interferon therapy

“…Although less than 10% of patients with fulminant, acute or chronic hepatitis due to non‐A to E viruses and autoimmune liver diseases are positive for GBV‐C/HGV, 9–11 a high prevalence of GBV‐C/HGV has been reported by Yoshiba et al in Japanese patients with non‐A to E fulminant hepatitis. 12 Recently, Heringlake et al have reported an association between fulminant hepatic failure and a specific strain of GBV‐C/HGV.…”