Gaze Palsy, Organomegaly, and Inspiratory Stridor: A Diagnostic Triad

Madaan, Priyanka; Bhagwat, Chandana; Kesavan, Shivan; Saini, Lokesh; Sankhyan, Naveen

doi:10.1007/s12098-020-03489-4

Cited by 1 publication

(1 citation statement)

References 4 publications

(5 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…ADS in children evolve either as a monophasic illness such as acute demyelinating encephalomyelitis (ADEM), transverse myelitis (TM), optic neuritis (ON), or clinically isolated syndrome (CIS) or as recurrent ones with relapses such as multiphasic disseminated encephalomyelitis (MDEM), multiple sclerosis (MS), or neuromyelitis optica spectrum disorders (NMOSDs). 1 2 ADS (combined) are the most common immune-mediated neurological disorders in children. Autoimmunity underlies the pathogenesis of ADS and with the advent of newer technology, specific autoantibodies have been associated with pediatric ADS.…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence of MOG and AQP4 Antibodies and Outcomes in an Indian Cohort of Pediatric Acquired Demyelinating Syndromes

et al. 2022

Self Cite

View full text Add to dashboard Cite

This study aimed to determine the seropositivity of myelin oligodendrocyte glycoprotein antibodies (MOG-Ab) and aquaporin-4 antibodies (AQP4-Ab) and outcomes in children with acquired demyelinating syndromes (ADS). Children (6months-15years) with suspected ADS were enrolled and tested for MOG-Ab and AQP4-Ab prospectively over 18 months at a tertiary-care hospital in North India. Children with proven non-immune mediated neurological disorders were enrolled as controls. Of 79 children with suspected ADS, 66 were enrolled. Among the enrolled children with ADS, ADEM (25) was the commonest first clinical event followed by ON (20) and TM [19; one child had ON and TM simultaneously (NMOSD)], while two children had CIS apart from ON and TM. Fourteen (21.2%, CI 11.3-31.1) tested positive for one antibody [12 (18.1%; 95% CI 10.5-25.5%) for MOG-Ab and two (3%; 95% CI 0-7.2%) for AQP4-Ab]. None of the 62 controls tested positive for any antibody. The final diagnosis in those with the monophasic ADS was ADEM (21), ON (13), TM (16), and other CIS (1) while that in children with recurrent events was MDEM (2), NMOSD (3), ADEM-ON (4), recurrent ON (4), and MS (2). Among those with the first event, 4/51 (7.8%; 95%CI 0.5-15.2%) were MOG-Ab positive and two AQP4-Ab positive, whereas, 8/15 [53.3%, (95%CI: 28.1-78.6%)] with recurrent events [MDEM (2), ADEM-ON (4), recurrent ON (1), and recurrent TM (1)] were MOG-Ab positive. Hence, MOG-Ab are the most common antibodies detected in one in five children with pediatric ADS, especially in relapsing disease. AQP4-Ab are rare in children with ADS.

show abstract

Section: Introductionmentioning

confidence: 99%