Gaviscon and Carobel compared with cisapride in gastro-oesophageal reflux.

Greally, Peter; Hampton, F J; MacFadyen, U M; Simpson, Hamish

doi:10.1136/adc.67.5.618

Cited by 44 publications

(30 citation statements)

References 23 publications

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“…110 -115 In 1 study, the combination of Gaviscon plus Carobel was superior to cisapride to relieve symptoms of reflux. 112 In a randomized, multicenter comparison of sodium alginate and cisapride in 353 adults with uncomplicated GER, Gaviscon was reported to have overall superior symptom relief. 116 A large pediatric randomized controlled study is expected to confirm its efficacy.…”

Section: Proposed Diagnostic and Therapeutic Approachmentioning

confidence: 98%

Gastroesophageal Reflux and Cow Milk Allergy: Is There a Link?

Salvatore¹,

Vandenplas

2002

Pediatrics

110

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Gastroesophageal reflux (GER) and cow milk allergy (CMA) occur frequently in infants younger than 1 year. In recent years, the relation between these 2 entities has been investigated and some important conclusions have been reached: in up to half of the cases of GER in infants younger than 1 year, there may be an association with CMA. In a high proportion of cases, GER is not only CMA associated but also CMA induced. The frequency of this association should induce pediatricians to screen for possible concomitant CMA in all infants who have GER and are younger than 1 year. With the exception of some patients with mild typical CMA manifestations (diarrhea, dermatitis, or rhinitis), the symptoms of GER associated with CMA are the same as those observed in primary GER. Immunologic tests and esophageal pH monitoring (with a typical pH pattern characterized by a progressive, slow decrease in esophageal pH between feedings) may be helpful if an association between GER and CMA is suspected, although the clinical response to an elimination diet and challenge is the only clue to the diagnosis. This article reviews the main features of GER and CMA, focusing on the aspects in common and the discrepancies between both conditions.

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Section: Proposed Diagnostic and Therapeutic Approachmentioning

confidence: 98%

Gastroesophageal Reflux and Cow Milk Allergy: Is There a Link?

Salvatore¹,

Vandenplas

2002

Pediatrics

110

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“…As indicated by a few observations in infants [15,30] and several studies in adults [6,101], the drug can heal oesophagitis. When given in monotherapy, it is as effective as the combination of Gaviscon (an alginate-antacid) and a milk thickener (Carobel) [52]. It is at least as effective as cimetidine in reducing oesophageal acid exposure time (both given in combination with Gaviscon) [47].…”

Section: Cisapridementioning

confidence: 99%

A critical appraisal of current management practices for infant regurgitation - recommendations of a working party

Vandenplas

Belli²,

Benhamou

et al. 1997

European Journal of Pediatrics

126

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A critical appraisal of current management practices for infant regurgitation: recommendations of a working party Vandenplas, Y.; Belli, D.; Benhamou, P.; Cadramel, S.; Cezard, J.P.; Cucchiara, S.; Dupont, C.; Faure, C.; Gottrand, F.; Hassall, E.; Heymans, H.S.A.; Kneepkens, C.M.F.; Sandhu, B. Published in:European Journal of Pediatrics DOI:10.1007/s004310050613Link to publication Citation for published version (APA):Vandenplas, Y., Belli, D., Benhamou, P., Cadramel, S., Cezard, J. P., Cucchiara, S., ... Sandhu, B. (1997). A critical appraisal of current management practices for infant regurgitation: recommendations of a working party. European Journal of Pediatrics, 156, 343-357. DOI: 10.1007/s004310050613 General rightsIt is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulationsIf you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Abstract Regurgitation is a common manifestation in infants below the age of 1 year and a frequent reason of counselling of general practitioners and paediatricians. Current management starts with postural and dietary measures, followed by antacids and prokinetics. Recent issues such as an increased risk of sudden infant death in the prone sleeping position and persistent occult gastrooesophageal reflux in a subset of infants receiving milk thickeners or thickened ''anti-regurgitation formula'' challenge the established approach. Therefore, the clinical practices for management of infant regurgitation have been critically evaluated with respect to their efficacy, safety and practical implications.

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“…Do analizy na podstawie kryteriów włączenia zakwalifikowano 9 badań z randomizacją, którymi objęto 411 dzieci w wieku od urodzenia do 17 lat [3][4][5][6][7][8][9][10][11]. Podsumowanie badań przedstawiono w tabeli I. W zakwalifikowanych do przeglądu badaniach porównano alginiany z placebo (4 badania, n = 172), blokerem receptorów histaminowych H2 (1 badanie, n = 47), inhibitorem pompy protonowej (1 badanie, n = 32), lekami prokinetycznymi, w tym z cizaprydem (1 badanie, n = 50) oraz z metoklopramidem (1 badanie, n = 30).…”

Section: Wynikiunclassified

“…[8] badaniem objęli 50 dzieci z GER w wieku 2-18 miesięcy, porównując alginian z cizaprydem. Parametry pH-metryczne w obu grupach były podobne.…”

Section: Alginiany W Porównaniu Z Lekami Prokinetycznymiunclassified

Alginiany w leczeniu refluksu żołądkowo-przełykowego u dzieci: przegląd systematyczny badań z randomizacją

Konarska¹,

Gieruszczak‐Białek²,

Pieścik-Lech³

et al. 2015

Pediatria Polska

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Gaviscon and Carobel compared with cisapride in gastro-oesophageal reflux.

Abstract: We compared the efficacy of the prokinetic agent cisapride with that of Gaviscon (an alginate/alkaline compound) plus Carobel

Cited by 44 publications

References 23 publications

Gastroesophageal Reflux and Cow Milk Allergy: Is There a Link?

Gastroesophageal Reflux and Cow Milk Allergy: Is There a Link?

A critical appraisal of current management practices for infant regurgitation - recommendations of a working party

Alginiany w leczeniu refluksu żołądkowo-przełykowego u dzieci: przegląd systematyczny badań z randomizacją

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